Mycaranthes latifolia (Orchidaceae), a new record for Vietnam

DANG, MINH QUAN; Ormerod, Paul; Bui, Van Huong; Truong, Quang Tam; Duong, Minh Tam Thao Ngoc; Dang, Viet-Cuong; Trương, Bá Vương

doi:10.22244/rheedea.2021.31.03.12

Cited by 2 publications

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“…Dendrobium is one of the largest genera in the flowering family Orchidaceae, with more than 1500 species, mostly found in Asia and Australia . Several species of Dendrobium plants have been used as traditional medicines in China, India, and Southeast Asia for treatment of skin disorders, reducing fever, headache and stomachache, and promoting body fluids. , Dendrobium crumenatum Sw. (Thai name Wai Tamoi) is an epiphytic plant that is distributed around Southeast Asia (Thailand, Philippines, Indonesia), India, and Hawaii. − D. crumenatum has been used in traditional medicine as juices for treatment of earache and a poultice for curing boils and pimples . Extracts from D. crumenatum exhibited potential antimicrobial activity .…”

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confidence: 99%

Immunomodulatory Effects of New Phenanthrene Derivatives from Dendrobium crumenatum

et al. 2023

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Three new phenanthrene derivatives (1, 2, 4), one new fluorenone (3), and four known compounds (5–8) were isolated from the ethyl acetate extract of Dendrobium crumenatum Sw. stems using column chromatography. The chemical structures were elucidated by analysis of spectroscopic data. The absolute configuration of 4 was determined by electronic circular dichroism calculation. We also evaluated the immunomodulatory effects of compounds isolated from D. crumenatum in human peripheral blood mononuclear cells from healthy individuals and those from patients with multiple sclerosis in vitro. Dendrocrumenol B (2) and dendrocrumenol D (4) showed strong immunomodulatory effects on both CD3+ T cells and CD14+ monocytes. Compounds 2 and 4 could reduce IL-2 and TNF production in T cells and monocytes that were treated with phorbol-12-myristate-13-acetate and ionomycin (PMA/Iono). Deep immune profiling using high-dimensional single-cell mass cytometry could confirm immunomodulatory effects of 4, quantified by the reduction of activated T cell population under PMA/Iono stimulation, in comparison to the stimulated T cells without treatment.

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confidence: 99%

Immunomodulatory Effects of New Phenanthrene Derivatives from Dendrobium crumenatum

et al. 2023

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“…This plant is an epiphytic orchid (size 40-100 cm) with pseudobulbs. The flower is 3-4 cm, white, having white three sepals and two petals with yellow disc on the lip (Meesawat & Kanchanapoom, 2007;Ram et al, 2015). However, the phytochemical studies and biological activities of this plant have not been reported.…”

Section: Dendrobium Crumenatum Swmentioning

confidence: 99%

“…Several species of Dendrobium plants have been used as traditional medicines in China, India, and Southeast Asia for treatment of skin disorders, reducing fever, headache and stomachache, and promoting body fluids (Wang, 2021a(Wang, , 2021b. Dendrobium crumenatum Sw. (Thai name Wai Tamoi) is an epiphytic plant that is distributed around Southeast Asia (Thailand, Philippines, Indonesia), India, and Hawaii (Meesawat et al, 2008;Ram et al, 2015;Vaddhanaphuti, 2005). D. crumenatum has been used in traditional medicine as juices for treatment of earache and a poultice for curing boils and pimples (Wiart, 2012).…”

Section: Immunomodulatory Effects Of New Phenanthrene Derivatives Fro...mentioning

confidence: 99%

Anti-inflammatory compounds in human peripheral blood mononuclear cells from dendrobium species

Kongkatitham

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In these studies, four new compounds including three phenanthrene derivatives (dendrocrumenols A, B and D) and one fluorenone (dendrocrumenol C) and four known compounds including gigantol, 3,7-dihydroxy-2,4,8-trimethoxyphenanthrene, densiflorol B�and cypripedin were isolated from Dendrobium crumenatum Sw. Each structure of isolated compounds from D. crumenatum was elucidated by spectroscopic data. These isolated compounds were then evaluated for anti-inflammatory effects�in human peripheral blood mononuclear cells (PBMCs). Among the tested compounds, dendrocrumenols B and D showed the most promising anti-inflammatory effects�through inhibition of tumor necrosis factor tumor (TNF) and interleukin-2 (IL-2) in monocytes and T cells. The deep immune profiling using high-dimensional single-cell mass cytometry (CyTOF) could confirm the anti-inflammatory effects based on immunomodulation of dendrocrumenol D through the decreasing of activated T cell population in phorbol-12-myristate-13-acetate and ionomycin (PMA/Iono) stimulation in human PBMCs. Next, the seven known bibenzyls isolated from Dendrobium plants were investigated the immunomodulatory effects in lipopolysaccharide (LPS)-induced human PBMCs. Two bibenzyls, moscatilin and crepidatin, exhibited the strongest inhibitory effect of TNF-expressed monocytes. The deep immune profiling using CyTOF could confirm the anti-inflammatory activity based on�immunomodulation effect of crepidatin through reduction of NK cells, pSTAT5+ non-classical monocytes and monocytes expressing co-stimulatory molecule CD86.

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Mycaranthes latifolia (Orchidaceae), a new record for Vietnam

Cited by 2 publications

References 3 publications

Immunomodulatory Effects of New Phenanthrene Derivatives from Dendrobium crumenatum

Immunomodulatory Effects of New Phenanthrene Derivatives from Dendrobium crumenatum

Anti-inflammatory compounds in human peripheral blood mononuclear cells from dendrobium species

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