MYB Expression and Translocation in Adenoid Cystic Carcinomas and Other Salivary Gland Tumors With Clinicopathologic Correlation

West, Robert B.; Kong, Christina S.; Clarke, Nicole; Gilks, Thea; Lipsick, J S; Cao, Hongbin; Kwok, Shirley; Montgomery, Kelli; Varma, Sushama; Le, Quynh‐Thu

doi:10.1097/pas.0b013e3182002777

Cited by 249 publications

(269 citation statements)

References 9 publications

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“…Though there is some disagreement in the literature regarding the percent of ACC tumors harboring this molecular alteration, most subsequent studies have shown that the majority of ACC have a disrupted MYB gene and/ or evidence of a MYB-NFIB fusion RNA transcript [32][33][34][35][36]. One of the largest independent cohorts separate from the Stenman group came from a study at Stanford University, where 37 cases of ACC were studied by fluorescence in situ hybridization (FISH) of the MYB and NFIB loci, with 65 % of cases showing abnormalities of these loci [34].…”

Section: Introductionmentioning

confidence: 99%

“…One of the largest independent cohorts separate from the Stenman group came from a study at Stanford University, where 37 cases of ACC were studied by fluorescence in situ hybridization (FISH) of the MYB and NFIB loci, with 65 % of cases showing abnormalities of these loci [34]. An example of an ACC tumor displaying typical FISH findings for a broken-apart MYB gene locus is shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

“…One research group showed evidence that some ACC tumors that did not contain a translocated MYB gene had elevated levels of wild-type MYB transcript and protein through an unknown mechanism [32]. While, as previously noted, the majority of ACC will show strong MYB immunoreactivity, this stain cannot be used to exclude the diagnosis of ACC, as some tumors (up to a third of cases) that otherwise meet the histologic diagnosis of ACC may show weak or negative MYB staining [34,36,37]. MYB staining is also not specific for ACC, being observed in several other tumor types, including basaloid squamous cell carcinoma, an occasional histologic mimic of ACC [34,36].…”

Section: Introductionmentioning

confidence: 99%

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Adenoid Cystic Carcinoma: Clinical and Molecular Features

Moskaluk

2013

Head and Neck Pathol

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The clinical features and common molecular alterations of adenoid cystic carcinoma (ACC) are reviewed in this paper. ACC is an uncommon neoplasm that most frequently arises in salivary glands and related tissue in the head and neck region. ACC has distinct histologic features, with cribriform and tubular growth patterns of basaloid cells displaying a predominantly myoepithelial cellular phenotype. This neoplasm also has uncommon clinical features of rare regional lymph node metastasis and a prolonged but relentlessly progressive clinical course. Clinical outcome in ACC is correlated to histologic grade, which is correlated to the degree of aneuploidy and genetic alterations present in the tumor genomes. Recent studies have identified that the majority of ACC contain alterations of the MYB gene, usually resulting in a fusion gene product with the NFIB gene by a t(6;9) translocation event. The molecular consequences of this alteration are incompletely understood, as are secondary molecular alterations that contribute to the neoplastic phenotype of ACC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adenoid Cystic Carcinoma: Clinical and Molecular Features

Moskaluk

2013

Head and Neck Pathol

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“…The tubular variant of adenoid cystic carcinoma features an infiltrative pattern of growth frequently associated with perineural invasion, which was not observed in the case described above. Assessing the presence of MYB expression, which occurs in a subset of adenoid cystic carcinomas, via immunohistochemical study may be helpful in ruling out this differential [10,11].…”

Section: Discussionmentioning

confidence: 99%

Hybrid Intercalated Duct Lesion of the Parotid: Diagnostic Challenges of a Recently Described Entity with Fine Needle Aspiration Findings

Mok

Pang

Teh

et al. 2015

Head and Neck Pathol

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Intercalated duct lesions (IDL) of the salivary glands are recently described, and encompass both hyperplasia and benign neoplasms that remain incompletely understood. IDLs have been linked to various benign and low-grade malignant salivary gland neoplasms. We herein present a case of a 77 year old woman with an IDL of the parotid composed of both a hyperplastic and an adenomatous component and report, for the first time, the fine needle aspiration findings of such a lesion. This case illustrates the morphologic spectrum of an IDL, as well as challenges in rendering an accurate cytological and histologic diagnosis. The potential diagnostic pitfalls presented by the hybrid pattern of this lesion are also discussed.Keywords Intercalated duct lesion Á Intercalated duct hyperplasia Á Intercalated duct adenoma Á Salivary gland Á Fine needle aspiration cytology Á Parotid Case ReportA 77 year old Malay woman presented with an asymptomatic subcentimeter nodule in the superficial parotid gland. The patient had a history of metastatic papillary thyroid carcinoma (PTC) 17 years prior to presentation that was treated with total thyroidectomy and adjuvant radioactive iodine. At the time of presentation she was undergoing radioactive iodine treatment following surgery for local and nodal recurrent PTC, during which a magnetic resonance imaging (MRI) scan showed an ovoid, enhancing nodule in the left superficial parotid measuring 9 mm (Fig. 1).On examination, a vaguely palpable nodule was present in the left parotid gland. Facial nerve function was preserved. A thyroidectomy scar and previously documented right vocal cord paralysis was noted. There was no palpable cervical lymphadenopathy.Fine needle aspiration biopsy of the parotid nodule was performed. This showed sheets and clusters of basaloid epithelial cells with high nuclear to cytoplasmic ratio (Fig. 2a, c); on high power magnification, the epithelial cells displayed fairly uniform, round to ovoid nuclei (Fig. 2b, d). Small amounts of dense stromal material were seen at the periphery of a few cell clusters (Fig. 2c, d). No plasmacytoid or spindled myoepithelial cells were identified. There was no evidence of high-grade cytological atypia, nuclear features of papillary thyroid carcinoma, or necrotic debris. A cytological diagnosis of a salivary gland basaloid neoplasm was rendered and excision was recommended.A left near-total parotidectomy was performed. On gross examination, the cut surface of the specimen revealed a mostly well circumscribed, firm, homogenously tan-white nodule measuring 0.7 cm (Fig. 3a). Multiple unremarkable intra-and peri-parotid lymph nodes ranging from 0.2 to 0.6 cm were present. Microscopically, there was a partially encapsulated lesion with two components: a nodular component and an adjacent irregular component. The nodular component was composed of closely packed, wellformed tubules with little intervening stroma (Fig. 3b). The tubules were lined by a single layer of cuboidal cells with cytologically bland, rounded nuclei and moderat...

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“…Recently, a recurrent t (6; 9) (q22-23; p23-24) translocation was found in ACCs, that ultimately results in the fusion of MYB and NFIB gene. This fusion leads to the deregulation of the expression of MYB, and it is likely to be a critical step in oncogenesis for ACC [11].…”

Section: Immunohistochemically Accs Can Be Divided Into Two Groupsmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Buccal Mucosa: A Case Report with Review of Literature

Santhanam¹,

Aravindhan

2014

JCDR

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A 48-year-old female patient presented with complaint of a swelling in the left cheek, in relation to left upper back tooth region. The swelling was present since 1 year and it had arisen as a small one, after extraction of a decayed left upper back tooth. History revealed that the swelling had increased gradually to attain its present size and that it was not associated with pain. There was no relevant medical, surgical or personal history. On extra oral examination, there was no evidence of erythema, ulceration or ecchymosis. Single left submandibular lymph node that was mobile, firm, non-tender and of size 0.5x0.5 cm, was palpable. Intra oral examination revealed a single localized dome shaped swelling of size 2x3 cm in the left buccal mucosa, in relation to 27 region, which extended posteriorly till the faucial pillars of the tonsils [Table/ Fig-1]. The mucosa which overlay the swelling was erythematous in nature and its surface was smooth. There was no surface discharge, the swelling was firm in consistency and it was nontender. The swelling was fixed to the underlying tissue and the area which surrounded the swelling, appeared to be normal. Clinical differential diagnosis included benign mesenchymal neoplasms, reactive or inflammatory conditions of minor salivary glands, benign or low grade malignant tumours of salivary gland origin, and metastatic tumour deposits of distant site. An orthopantomograph was taken and it revealed no bony changes in the maxilla or the mandible. Lesion was excised in toto, it was Dentistry Section aBstRaCt Minor salivary gland neoplasms of the buccal mucosa are relatively uncommon. Adenoid cystic carcinoma (ACC), a well-defined entity, occurs most of the times in the parotid, submandibular glands and palate, as far as the intraoral site is concerned. Adenoid cystic carcinoma tends to have an indolent, extended clinical course with wide local infiltration and late distant metastases. We are presenting a case of an adenoid cystic carcinoma of the buccal mucosa in a 48-year-old female patient.[table/ Fig-1]: Clinical picture depicting a mass of the buccal mucosa

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MYB Expression and Translocation in Adenoid Cystic Carcinomas and Other Salivary Gland Tumors With Clinicopathologic Correlation

Cited by 249 publications

References 9 publications

Adenoid Cystic Carcinoma: Clinical and Molecular Features

Adenoid Cystic Carcinoma: Clinical and Molecular Features

Hybrid Intercalated Duct Lesion of the Parotid: Diagnostic Challenges of a Recently Described Entity with Fine Needle Aspiration Findings

Adenoid Cystic Carcinoma of the Buccal Mucosa: A Case Report with Review of Literature

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