Myasthenia Gravis Exacerbation Following Second Dose of mRNA-1273 Vaccine

Desai, Urvi

doi:10.17161/rrnmf.v2i2.15342

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Both new-onset myasthenia gravis [ 42 , 43 ] and exacerbation of existing disease have been reported with COVID vaccines. [ 44 , 45 ] Although rare, acute transverse myelitis has also been reported in association with COVID vaccine. Hirose et al .…”

Section: Autoimmune Manifestations Following Covid-19 Vaccinationmentioning

confidence: 99%

Corona virus disease-19 vaccine–associated autoimmune disorders

Awan

Samreen

Salim

et al. 2022

Rheumatology and Immunology Research

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Coronavirus disease is a highly infectious viral disease caused by severe acute respiratory syndrome virus (SARS nCoV2). It was declared a pandemic within a few months of identification of its index case. The spread of COVID-19 across the globe was rampant, overwhelming healthcare systems and crippling global economies. Since the world was caught off guard by the pandemic, vaccine programs had to be rolled out in emergency to curb its spread. Ten vaccines have been granted Emergency Use Authorization thus far. Much of the side effects we know today are post-marketing adverse effects. Most of them are mild like myalgia and injection-site reactions, but a few of them such as post-vaccination autoimmune diseases have alerted the medical community. These include vaccine-induced thrombotic thrombocytopenia, autoimmune hepatitis, myocarditis, and Graves’ disease. We attempt to summarize the diverse autoimmune phenomena reported after COVID-19 vaccination, with an aim to sensitize the medical community so that they can be better equipped in management when confronted with these diseases. This review by no means refutes the potential benefit of COVID-19 vaccination which has consolidated its place in preventing infections and substantially reducing severity and mortality.

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Section: Autoimmune Manifestations Following Covid-19 Vaccinationmentioning

confidence: 99%

Corona virus disease-19 vaccine–associated autoimmune disorders

Awan

Samreen

Salim

et al. 2022

Rheumatology and Immunology Research

View full text Add to dashboard Cite

show abstract

The relationship between myasthenia gravis and COVID-19: a systematic review

Tugasworo

Kurnianto

Retnaningsih

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Introduction Viral infection such as coronavirus disease 2019 (COVID-19) can exacerbate and aggravate neurological disorders due to autoimmune etiology like myasthenia gravis (MG). Experimental therapies used in COVID-19 are also factors that can cause the worsening of MG symptoms. This review aimed to assess and conclude the research-based study systematically to analyze the relationship of MG and COVID-19. Method This study was conducted in accordance to Cochrane handbook for systematic reviews and the guideline of preferred reporting items for systematic review and meta-analysis (PRISMA) and synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. Inclusion criteria in this review were primary studies of every design, articles published in English around January 2000–October 2021, and the study used human as subject. A systematic literature finding was applied in 15 electronic scientific resources. The authors evaluated the study quality and risk of bias of each retrieved article. Results The authors found the study through electronic scientific resources that met inclusion and exclusion criteria. The authors evaluated 362 articles identified in literature searching, 22 articles met the criteria for this review and then underwent the evaluation of study quality and risk of bias. Conclusion COVID-19 infection can increase the risk of new-onset MG, myasthenic crisis, respiratory failure, and mortality rate due to cytokine storm in MG patients. The management of COVID-19 patients with MG is tailored to each person and based on national guidelines and local expert recommendations.

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Myasthenia Gravis Exacerbation Following Second Dose of mRNA-1273 Vaccine

Abstract: NA

Cited by 2 publications

References 6 publications

Corona virus disease-19 vaccine–associated autoimmune disorders

Corona virus disease-19 vaccine–associated autoimmune disorders

The relationship between myasthenia gravis and COVID-19: a systematic review

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