Coronavirus disease is a highly infectious viral disease caused by severe acute respiratory syndrome virus (SARS nCoV2). It was declared a pandemic within a few months of identification of its index case. The spread of COVID-19 across the globe was rampant, overwhelming healthcare systems and crippling global economies. Since the world was caught off guard by the pandemic, vaccine programs had to be rolled out in emergency to curb its spread. Ten vaccines have been granted Emergency Use Authorization thus far. Much of the side effects we know today are post-marketing adverse effects. Most of them are mild like myalgia and injection-site reactions, but a few of them such as post-vaccination autoimmune diseases have alerted the medical community. These include vaccine-induced thrombotic thrombocytopenia, autoimmune hepatitis, myocarditis, and Graves’ disease. We attempt to summarize the diverse autoimmune phenomena reported after COVID-19 vaccination, with an aim to sensitize the medical community so that they can be better equipped in management when confronted with these diseases. This review by no means refutes the potential benefit of COVID-19 vaccination which has consolidated its place in preventing infections and substantially reducing severity and mortality.
Objective: To determine the presence of iron deficiency anemia and assess the relationship of various factors with the presence of anemia among the patients of inflammatory bowel disease reporting to Military Hospital, Rawalpindi. Study Design: Cross sectional study. Place and Duration of Study: Department of General Medicine, Pak Emirates Military Hospital Rawalpindi, from Jan to Dec 2018. Methodology: Two hundred cases were recruited in this study, which were diagnosed as inflammatory bowel disease in medical outpatient department (OPD) by a consultant medical specialist or gastroenterologist. Iron deficiency anemia was diagnosed on the basis of hemoglobin and ferritin levels. Relationship of age, gender, duration of inflammatory bowel disease, type of inflammatory bowel disease and poly-pharmacy was taken into account with the presence of iron deficiency anemia among the patients suffering from inflammatory bowel disease. Results: A total of 106 patients were males and 94 were females. Most common type of inflammatory bowel disease was ulcerative colitis 118 (59%). Out of 200 patients of inflammatory bowel disease, 111 (44.5%) showed the presence of iron deficiency anemia while 89 (55.5%). Long duration of illness and poly-pharmacy had a significant correlation (p-value <0.05) with the presence of iron deficiency anemia among the patients of Crohn’s disease or ulcerative colitis. Conclusion: High frequency of iron deficiency anemia was observed in the patients of inflammatory bowel disease in a tertiary care hospital of our country. Patients with long standing inflammatory diseases or using multiple pharmacological agents for the control of their disease had more risk for....
Objective: To assess the frequency, variants, clinical profile and outcome of patients admitted with the diagnosis of GuillianBarre Syndrome at neurology unit of a tertiary care teaching hospital of Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Neurology department, Pak Emirates Military Hospital Rawalpindi, from Jan to Dec 2018. Methodology: This study was conducted on 42 patients of Guillian-Barre Syndrome admitted in hospital. Demographic profile included age, gender, and the symptoms with which the patient presented. Medical and neurological complications were also documented among the target population. Outcomes included recovery, shifting to intensive care unit and death. Results: Out of 42 patients included in the final analysis 25 were male and 17 were female. Most of the patients presented with lower limb weakness followed by numbness. Acute inflammatory demyelinating polyneuropathy was the commonest while cranial nerve variant was least reported. Motor deficit were the commonest complication faced by the patients followed by respiratory involvement. Out of 42 patients, 34 (80.9%) recovered, 4 (9.5%) were shifted to the intensive care unit and 4 (9.5%) died. Conclusion: This study gives an insight into the pattern of a fairly common neurological illness which if diagnosed and managed in time has a good outcome in our set up. Management of critically ill Guillian-Barre Syndrome patients involves a multidisciplinary team with a need of intensive care unit during the course of management. Variety of types and presentations should be part of training of neurology doctors as well as internal medicine doctors.
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