MXene-modified 3D printed scaffold for photothermal therapy and facilitation of oral mucosal wound reconstruction

Multifunctional MXene-Based Platforms for Soft and Bone Tissue Regeneration and Engineering

“…There are several techniques employed for MXene-based scaffold synthesis such as template-assisted methods, electrospinning, and 3D printing. 72,115 Each method has its own advantages and limitations, impacting pore morphology and overall scaffold performance. For instance, template-assisted methods allow precise control over pore size and distribution, while 3D printing enables the fabrication of complex structures with high accuracy.…”

“…MXene-based scaffolds and 3D-printed MXene-based scaffolds offer promising potential for various applications. There are several techniques employed for MXene-based scaffold synthesis such as template-assisted methods, electrospinning, and 3D printing. , Each method has its own advantages and limitations, impacting pore morphology and overall scaffold performance. For instance, template-assisted methods allow precise control over pore size and distribution, while 3D printing enables the fabrication of complex structures with high accuracy. ,, For instance, a novel and adaptable extrusion-based 3D printing technique was presented for the fabrication of microneedle scaffolds incorporating MXene and spidroin .…”

MXene-based composites in smart wound healing and dressings

“…The heat generated by MXenes under NIR light can increase blood circulation, which helps deliver oxygen and nutrients to the wound area and remove waste products. Enhanced blood flow promotes the migration and proliferation of cells involved in wound healing, such as fibroblasts and endothelial cells 113 . In addition, the heat can induce collagen remodeling and the synthesis of extracellular matrix components, promoting wound closure and tissue regeneration.…”

“…Both in vivo and in vitro experiments demonstrated that the M-CSQ composite scaffold was effective in killing SCC25 and CAL27 cells as well as inhibiting tumor growth. 113 The photothermal effect of MXenes can also aid in the controlled release of therapeutic agents. By incorporating MXenes into wound dressings or coatings and then applying NIR light, the localized heat can trigger the release of encapsulated bioactive molecules, such as growth factors or antimicrobial agents.…”

“…Enhanced blood flow promotes the migration and proliferation of cells involved in wound healing, such as fibroblasts and endothelial cells. 113 In addition, the heat can induce collagen remodeling and the synthesis of extracellular matrix components, promoting wound closure and tissue regeneration.…”