Mutual Relationship Between Sleep Disorders, Quality of Life and Psychosocial Aspects in Patients With Psoriasis

Abstract

Psoriasis is a chronic, autoimmune skin disease affecting about 2–4% of the worldwide population. It is now perceived as a systemic disease because of the complex pathogenesis and multiple comorbidities. It leads to decreased quality of life and productivity of patients. Nowadays, sleep disorders are investigated as well in relation to psoriasis as another possible comorbidity. This review focuses on possible negative effects of sleep deprivation, decreased quality of life, and psychosocial status in patients with psoriasis and highlights their mutual, complex relationship of divergent consequences. The relationship between sleep disorders and psychosocial status in patients with psoriasis is bidirectional and resembles a vicious circle, one abnormality triggering the other. Sleep disorders additionally increase the risk of metabolic and psychiatric diseases in psoriatic patients who are already at increased risk of developing such disorders. There should be measures taken to screen patients with psoriasis for sleep disorders in order to diagnose early and treat.

Assessment of Life Quality, Stress and Physical Activity Among Patients with Psoriasis

“…Taking into account subjective symptoms related to skin lesions, comorbidities and often time-consuming or cost-effective treatment have a great impact on the decreased quality of life of patients with psoriasis. It was reported that patients with psoriasis are more often absent from work and are less efficient employees, which obviously exacerbate their stress and therefore the disease [ 13 , 14 ].…”

Interactions between Sleep and Emotions in Humans and Animal Models

“…In this way, a recent systematic review [107] having a similar hypothesis concluded that the need for further analysis is critical, since a few unbiased studies could support the positive emotions' effect on sleep in healthy individuals while limited empirical data were not sufficient to provide reasonable evidence for positive emotional outcomes in clinical population. Later studies managed to show that positive affect increased sleep quality [108][109][110], improved self-control, and prevented mood changes [111], in healthy individuals and chronic nonpsychiatric (e.g., thalassemia [112], psoriasis [113]) and psychiatric pathologies [114,115]. By exception, Bouwmans et al [116] reported no correlation between positive affect and sleep quality in depressed patients.…”

“…Currently, it is increasingly accepted that a good welfare is not merely the lack of negative emotions, but the presence of positive emotions. In this context, from the above discussed studies only Marakkemia et al [113] evaluated and highlighted the possible beneficial effects of encouraging positive emotions.…”

Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data

“…We have also proved that psoriatic patients more often suffer from different sleep disorders [ 11 ]. Moreover, they have been discovered to be less efficient workers or pupils and their life quality is significantly worse than the general population [ 12 ]. Although there are various topical and systemic treatments available for psoriasis, it is often very hard to manage the condition and its multiorgan comorbidities [ 13 , 14 ].…”

“…Although the microscopic picture of these two dermatoses is different, sometimes some features may be similar (for instance, the presence of acanthosis) [ 3 , 15 ]. Their pathogenesis is not fully understood, but autoimmune factors are suspected as one of the possible paths, along with drugs, infections, and stress that can trigger the lesions’ occurrence [ 12 , 15 ]. Moreover, both PSO and LP have been related to components of MS [ 6 , 19 ].…”