Mutual modulating effects of serotonin and dopamine on neurons of rat spinal ganglia

Абрамец, И. И.; Samoilovich, I. M.

doi:10.1007/bf01054134

Cited by 3 publications

(5 citation statements)

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“…Depolarizing ACh-induced potentials in neurons of invertebrates (mollusks) are related to increased permeability's of the membrane to ions of Na + , Ca 2+ , and small amounts of Cl -. Activation of nicotinic receptors induces mostly sodium permeability, while that of muscarinic receptors This conclusion was confirmed by the data obtained in experiments on different objects (neurons of invertebrates and vertebrates) [38,59,60,61] . It is obvious that the increase in the conductance through just calcium-activated potassium channels dependent on 5-НТ1А receptors but not through voltage-directed ones plays the main role [38] .…”

Section: Discussionsupporting

confidence: 59%

“…Activation of nicotinic receptors induces mostly sodium permeability, while that of muscarinic receptors This conclusion was confirmed by the data obtained in experiments on different objects (neurons of invertebrates and vertebrates) [38,59,60,61] . It is obvious that the increase in the conductance through just calcium-activated potassium channels dependent on 5-НТ1А receptors but not through voltage-directed ones plays the main role [38] . These effects are related to changes in the intracellular Са 2+ concentration, which was demonstrated on hippocampal neurons [62,63] .…”

Section: Discussionsupporting

confidence: 59%

“…Such modulation of cholinergic responses in the medial prefrontal cortex of rats is mediated by D1 and D2 receptors [37] . Mutual modulatory effects of such monoamines as DA and serotonin, when they act on neurons of the spinal ganglia of rats, is related to changes in the intracellular activity of secondary messengers [38] . Iontophoretic application of DA to neurons of the striatum modified the capability of glutamate of activating postsynaptic neurons; this finding is one more proof of the neuromodulatory role of DA [39] .…”

Section: Discussionmentioning

confidence: 99%

“…Analysis of two types of DA-initiated reactions in neurons of the spinal ganglia showed that depolarization responses are related to activation of D1 receptors and mediated by an increase in the conductivity of cAMPdependent sodium channels. At the same time, hyperpolarization responses are initiated by activation of D2 receptors; this effect increases the conductivity of potassium channels [38] . Application of DA and intracellular injection of cAMP evoked the appearance of an inward current related to an increase in the permeability for sodium ions [40] .…”

Section: Discussionmentioning

confidence: 99%

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Modulation of Synaptic Processes in Cortical Neurons in Response to Painful Stimulation and Analgesia

Labakhua¹,

Janashia²,

Gedevanishvili³

2015

International Journal of Neurology Research

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We studied effects of electrical stimulation of the substantia nigra (SN), locus coeruleus (LC), raphe nuclei (RN), substantia innominata (SIn), nucleus caudatus (NC) and central grey (CG) on postsynaptic processes evoked in neurons of the cat somatosensory cortex by excitation of nociceptive and non-nociceptive afferent inputs (intense stimulation of the dental pulp and moderate stimulation of the thalamic ventroposteromedial nucleus, VPMN, respectively). We analyzed intracellularly recorded activity of cortical cells activated exclusively by stimulation of nociceptors and cells activated by both nociceptive and non-nociceptive influences ("nociceptive" and "convergent" neurons). In neurons of both groups, stimulation of both nociceptive afferents and thalamic VPMN resulted in the development of successions of EPSP-action potential (AP) or their series-IPSP (IPSP duration 200-300 msec). Conditioning electrical stimulation of the above-mentioned nuclei induced suppression of synaptic reactions that occur in cortical neurons in response to stimulation of nociceptive inputs. The maximum decrease in the amplitude of the IPSP was observed at test intervals of 600 to 800 msec when stimulated nuclei containing biogenic amines and 100-150 msec at conditioning electrical stimulation of cholinergic structures. We observed certain parallelism between conditioning influent ions of CG activation and effects of systemic injections of morphine. Discusses is the physiological significance of presumebly dendritic action potentials observed in our experiments. Decrease in the amplitude or complete postsynaptic inhibition of IPSP in cortical neurons under different treatments associate with the occurrence of convulsive epileptic activity, and at the painful action with analgesic effect. Discussed are the mechanisms for modulatory influences exerted by conditioning stimulation of SN, LC, RN, NC, SIn and CG on the somatosensory neurons, activated upon excitation of high-threshold (nociceptive) afferent inputs. Such modulation is probably based on changes developing in both pre and post-synaptic intracortical mechanisms.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of Synaptic Processes in Cortical Neurons in Response to Painful Stimulation and Analgesia

Labakhua¹,

Janashia²,

Gedevanishvili³

2015

International Journal of Neurology Research

View full text Add to dashboard Cite

show abstract

“…Such modulation of cholinergic responses in the medial prefrontal cortex of rats is mediated by D 1 and D 2 receptors [19]. Mutual modulatory effects of such monoamines as DA and serotonin, when they act on neurons of the spinal ganglia of rats, is related to changes in the intracellular activity of secondary messengers [20]. Iontophoretic application of DA to neurons of the striatum modified the capability of glutamate of activating postsynaptic neurons; this finding is one more proof of the neuromodulatory role of DA [21].…”

Section: Discussionmentioning

confidence: 99%

Modulation of Postsynaptic Responses of Nociceptor-Activated Neurons of the Cat Somatosensory Cortex by Stimulation of the Substantia Nigra

et al. 2008

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We studied the effect of electrical stimulation of the substantia nigra (SN) on postsynaptic processes evoked in neurons of the somatosensory cortex of the cat by stimulation of nociceptive (intense stimulation of the dental pulp) and non-nociceptive (moderate, in strength, stimulations of the n. infraorbitalis and ventroposteromedial nucleus, VPM, of the thalamus) afferent inputs. The intracellularly recorded 7 cells activated exclusively by stimulation of dental nociceptors and 10 cells activated by both nociceptive and non-nociceptive afferent volleys (nociceptive and convergent cortical neurons, respectively) were examined in detail. Complexes EPSP-action potential-long-lasting IPSP (up to 200-300 msec) developed in neurons of both groups after stimulations of both nociceptive afferents and the thalamic VPM. Conditioning stimulation of the SN preceding test stimulation of the dental pulp or VPM with intervals from 100 to 700 msec resulted in selective suppression of IPSPs; their amplitudes decreased by 40-60%. The maximum effect in both cases was observed at conditioning/test intervals of 300 to 700 msec. Under conditions of SN stimulation, the release of dopamine, by affecting receptors and secondary messengers, modulates postsynaptic activity in the cortical GABA-ergic system and decreases the amplitude of IPSPs induced by stimulations of both nociceptors (dental pulp) and low-threshold afferent inputs (VPM of the thalamus). This process can be mediated by both pre-synaptic and post-synaptic mechanisms.

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Raphe Stimulation-Evoked Modulation of Postsynaptic Responses by Neurons of the Cat Somatosensory Cortex Activated by Stimulation of Nociceptors

2011

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We studied the effects of electrical stimulation of the raphe nuclei (RN) of the cat brain on postsynaptic potentials developing in somatosensory cortex neurons activated by nociceptive influences. Intracellular records were obtained from 15 cells, which were either selectively excited by stimulation of nociceptors (intense electrical stimulation of the dental pulp) or activated by both the above nociceptive and nonnociceptive (moderate stimulations of the infraorbital nerve or thalamic ventroposteromedial nucleus, VPMN) influences. In neurons of both groups, stimulation of both nociceptive afferents and the VPMN evoked complex responses (EPSP-AP-IPSP; IPSPs were 200 to 300 msec long). In some studied cortical neurons, isolated electrical stimulation of the RN (which caused the release of serotonin, 5-HT, in the cortex) resulted in relatively short-latency synaptic excitation, while inhibition was observed in other cells. In the case where stimulation of the RN was used as conditioning influence, such stimulation (independently of the kind of the initial response to RN stimulation) led to long-latency and long-lasting suppression of all components of the synaptic reactions evoked by excitation of nociceptors. The maximum of inhibition was observed at test intervals of 300 to 800 msec. The mechanisms underlying modulatory influences coming from the 5-НТ-ergic brainstem system to neurons of the somatosensory cortex, which are activated by excitation of high-threshold (nociceptive) afferent inputs, are discussed.

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Mutual modulating effects of serotonin and dopamine on neurons of rat spinal ganglia

Cited by 3 publications

References 2 publications

Modulation of Synaptic Processes in Cortical Neurons in Response to Painful Stimulation and Analgesia

Modulation of Synaptic Processes in Cortical Neurons in Response to Painful Stimulation and Analgesia

Modulation of Postsynaptic Responses of Nociceptor-Activated Neurons of the Cat Somatosensory Cortex by Stimulation of the Substantia Nigra

Raphe Stimulation-Evoked Modulation of Postsynaptic Responses by Neurons of the Cat Somatosensory Cortex Activated by Stimulation of Nociceptors

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