MutSα and MutLα immunoexpression analysis in diagnostic grading of oral epithelial dysplasia and squamous cell carcinoma

Jessri, Mahsa; Dalley, Andrew J.; Farah, Camile S.

doi:10.1016/j.oooo.2014.06.017

Cited by 23 publications

(24 citation statements)

References 29 publications

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“…This initial observation was subsequently confirmed by Jessri et al (19) that revealed a progressive reduction of hMLH1, hMSH2, and hPMS2 from mild, moderate, and severe dysplasia to OSCC. In a following study, Jessri et al (25) further confirmed the lower expression of hMLH1, hMSH2, hPMS2, and hMSH6 in more dysplastic OL and even more in OSCC, also highlighting the diagnostic utility of hMSH6 in the identification of carcinoma in situ.…”

Section: Mmr Expression In Oral Squamous Cell Carcinomasupporting

confidence: 54%

“…These results were confirmed by the same group that showed a lower expression of hMLH1 in more dysplastic OL, also revealing an inverse correlation with p53 and AgNOR expression (18). These authors suggested that hMLH1 alterations would represent an early molecular event in oral carcinogenesis, what was supported by Jessri et al (19) who confirmed a reduced expression of hMLH1, hPMS2, and hMSH2 in OL and in OSCC when compared to normal oral mucosa, also attributing a diagnostic role for these proteins.…”

Section: Mmr Expression In Oral and Lip Potentially Malignant Lesionsmentioning

confidence: 55%

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Mismatch repair system proteins in oral benign and malignant lesions

Amaral‐Silva

Martins

Pontes

et al. 2016

J Oral Pathology Medicine

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Different environmental agents may cause DNA mutations by disrupting its double-strand structure; however, even normal DNA polymerase function may synthesize mismatch nucleotide bases, occasionally demonstrating failure in its proofreading activity. To overcome this issue, mismatch repair (MMR) system, a group of proteins specialized in finding mispairing bases and small loops of insertion or deletion, works to avoid the occurrence of mutations that could ultimately lead to innumerous human diseases. In the last decades, the role of MMR proteins in oral carcinogenesis and in the development of other oral cavity neoplasms has grown, but their importance in the pathogenesis and their prognostic potential for patients affected by oral malignancies, especially oral squamous cell carcinoma (OSCC), remain unclear. Therefore, in this manuscript we aimed to review and critically discuss the currently available data on MMR proteins expression in oral potentially malignant lesions, in OSCC, and in other oral neoplasms to better understand their relevance in these lesions.

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Section: Mmr Expression In Oral Squamous Cell Carcinomasupporting

confidence: 54%

Section: Mmr Expression In Oral and Lip Potentially Malignant Lesionsmentioning

confidence: 55%

Mismatch repair system proteins in oral benign and malignant lesions

Amaral‐Silva

Martins

Pontes

et al. 2016

J Oral Pathology Medicine

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“…The incidence of male and female HPV‐related oropharyngeal cancers in Australia has significantly increased annually across both genders in line with global trends . Alternative theories for this increase relate to the importance of individual genetic variation with data suggesting a role for common polymorphisms in DNA repair enzymes among others …”

Section: Introductionmentioning

confidence: 96%

“…24,25 Alternative theories for this increase relate to the importance of individual genetic variation with data suggesting a role for common polymorphisms in DNA repair enzymes among others. [26][27][28][29] To date, however, there are no data assessing patient awareness, knowledge of risk factors, actual risk factors, patient delay, professional delay, diagnostic delay and access to health practitioners for oral cancer in the Australian health system. A key aim is to identify whether asymptomatic diagnosis is possible by analysing if these patients presented to any health professionals in the preceding months to years before symptoms began, suggesting missed opportunities for early diagnosis of malignant lesions or OPMDs.…”

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confidence: 99%

Missed opportunities for oral cancer screening in Australia

Webster

Batstone

Farah³

2019

J Oral Pathology Medicine

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Objectives Most patients with oral cancer lack early symptoms, therefore most present with advanced stage of disease. Early detection of oral cancer and oral potentially malignant disorders (OPMDs) in the asymptomatic phase via an opportunistic oral cancer screening examination is important as survival rates are significantly improved if the disease is treated at an earlier stage. The objective is to identify opportunities to achieve early stage diagnosis of oral cancer in Australian patients. Materials and Methods A cohort of 103 patients newly diagnosed with oral cancer were surveyed at a tertiary hospital Head and Neck Clinic. Patient awareness, knowledge, risk factors and diagnostic delay in oral cancer diagnosis were investigated. The asymptomatic period before diagnosis was studied to identify opportunities for improving opportunistic screening rates in Australia. Results Australian patients have poor awareness of oral cancer with 46% having never heard of oral cancer, and poor knowledge of risk factors for oral cancer. Only 7% were diagnosed in the asymptomatic phase and all by dental practitioners. Once symptomatic, median diagnostic delay was 9 weeks. In the asymptomatic phase before diagnosis, patients attended general medical practitioners far more often than general dental practitioners. Both groups rarely discussed risk factors for oral cancer (<10%) or performed opportunistic oral cancer screening examinations (<10%) with their patients. Conclusion Asymptomatic diagnosis of oral cancer at an earlier stage of disease is possible in the primary medical setting but increased awareness and knowledge are required in both patients and health practitioners.

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“…Continues)All the reviewed works were unanimous in recognizing the veracity and complexity of the Genomic Repair System, also called Mismatch Repair System (MMR), confirming the participation of repair gene proteins (such as hMSH2 and hMSH6) in patients with oral cancer and even of lesions that are susceptible to malignization [8][9][10][11][12][13][14][15]. To test the participation of hMSH2 and hMSH6 repair genes, some authors used immunohistochemical analysis as the technique, which evidenced the presence of different levels of these proteins, in different oral lesions prone to malignancy and/or malignant oral lesions, with variable laboratory and clinical significance 12,14,15. Thus, Pimenta et al,9 through this evaluation, verified that there is, even if reduced, a small expression of the hMSH2 protein in oral lichen planus when compared with normal oral mucosal epithelial tissue; this reduction of expression may suggest a greater susceptibility of lichen planus to mutation and, therefore, to differentiate into oral squamous cell carcinoma.…”

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confidence: 99%

Involvement of repair genes in oral cancer: A systematic review

Fonseca

Prosdócimi

Bianco

et al. 2019

Cell Biochemistry & Function

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Among the types of cancers that may occur in the oral cavity, squamous cell carcinomas (SCC) of the mouth have a higher incidence and are associated with increased rates of morbidity and mortality. Among steps from the beginning to the progression of the tumour, DNA Repair System is highlighted. The present study aims to conduct a systematic review of the literature on the expression of the repair genes hMSH2 and hMSH6 in patients with SCC in the mouth and oropharyngeal region. The search was performed in databases such as PubMed, Lilacs, and Scielo and included articles published in English from 1999 until 2015. The search in the above-mentioned databases initially yielded 15 scientific articles related to the proposed objective. After a detailed analysis of each of them, only 8 were included in the present review, precisely because they met the inclusion criteria determined in the method. All the reviewed works were unanimous in recognizing the veracity and complexity of the Genomic Repair System, also called Mismatch Repair System, confirming the participation of repair gene proteins (such as hMSH2 and hMSH6) in patients with oral cancer and even of lesions that are susceptible to malignization. Significance of the study: Worldwide, there are an estimated 300 thousand new cases of oral cancer per year. Studies have shown a greater risk in individuals who are smokers and alcohol consumers in developing mouth cancer. Many steps are observed from the beginning to the progression of the tumour, highlighted among them is the moment in which genetic, and epigenetic alterations will interfere in the functioning of the DNA Repair System. This work presents a survey of current knowledge about the involvement of repair genes, especially those of the MutSα system, in the development and progression of oral cancer.

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MutSα and MutLα immunoexpression analysis in diagnostic grading of oral epithelial dysplasia and squamous cell carcinoma

Abstract: Conclusion:The results suggest a diagnostic role for MMR proteins in OED and OSCC.

Cited by 23 publications

References 29 publications

Mismatch repair system proteins in oral benign and malignant lesions

Mismatch repair system proteins in oral benign and malignant lesions

Missed opportunities for oral cancer screening in Australia

Involvement of repair genes in oral cancer: A systematic review

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