2015
DOI: 10.1016/j.ijantimicag.2015.08.001
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Mutations in transcription factor Mrr2p contribute to fluconazole resistance in clinical isolates of Candida albicans

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Cited by 16 publications
(20 citation statements)
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References 27 publications
(43 reference statements)
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“…Clinically derived MRR2 alleles were introduced in a fluconazolesusceptible background to generate strains containing multiple single nucleotide polymorphisms (SNPs) in the MRR2 gene. In contrast to a previous report (28), we found no changes in fluconazole MIC or CDR1 expression upon introduction of any of the MRR2 SNPs observed in clinical isolates in our collection or that had been described previously.…”
contrasting
confidence: 99%
See 2 more Smart Citations
“…Clinically derived MRR2 alleles were introduced in a fluconazolesusceptible background to generate strains containing multiple single nucleotide polymorphisms (SNPs) in the MRR2 gene. In contrast to a previous report (28), we found no changes in fluconazole MIC or CDR1 expression upon introduction of any of the MRR2 SNPs observed in clinical isolates in our collection or that had been described previously.…”
contrasting
confidence: 99%
“…Three of these substitutions (R45Q, A459T, V486M) had not previously been described in the literature. The remaining four substitutions (S466L, A468G, S469T, T470N) had been previously found in resistant clinical C. albicans isolates and were reported to have an effect on fluconazole MIC and CDR1 expression (28). Within our collection, these four substitutions appeared in four clinical isolates and exclusively co-occurred with each other.…”
Section: Resultsmentioning
confidence: 51%
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“…albicans isolates. Indeed, three epidemiologically related isolates with elevated CDR1 expression levels contained a mutated MRR2 allele that caused CDR1 overexpression and increased fluconazole resistance when introduced into a drug-susceptible strain, demonstrating the clinical relevance of the predicted resistance mechanism [35]. …”
Section: Introductionmentioning
confidence: 99%
“…Tac1-indepndent CDR1 induction by farnesol can be largely attributed to Znc1 (and Mrr2) function. Interestingly, unlike Tac1 (27) and Mrr2 (52), no gain-of-function mutants of Znc1 have been reported to drive azole resistance in C. albicans . Of the well-characterized CDR1 inducers, farnesol is the only one considered to be a C. albicans metabolite.…”
Section: Discussionmentioning
confidence: 99%