C. albicans Zn Cluster Transcription Factors Tac1 and Znc1 are Activated by Farnesol to Up Regulate a Transcriptional Program Including the Multi-Drug Efflux Pump CDR1

Abstract

15Farnesol, a quorum-sensing molecule, inhibits C. albicans hyphal formation, affects 16 its biofilm formation and dispersal, and impacts its stress response. Several aspects 17 of farnesol's mechanism of action remain incompletely uncharacterized. Among 18 these are a thorough accounting of the cellular receptors and transporters for farnesol. 19This work suggests these themes are linked through the Zn cluster transcription 20 factors Tac1 and Znc1, and their induction of the multi-drug efflux pump Cdr1.