Mutations in the HFE Gene and Their Interaction with Exogenous Risk Factors in Hepatocellular Carcinoma

Fargion, Silvia; Stazi, Maria Antonietta; Fracanzani, Anna Ludovica; Mattioli, Michela; Sampietro, Maurizio; Tavazzi, Dario; Bertelli, C.; Patriarca, Valeria; Mariani, Chiara; Fiorelli, G.

doi:10.1006/bcmd.2001.0411

Cited by 39 publications

(22 citation statements)

References 28 publications

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“…Thus, these results keep in line with previous report [Fargion et al, 2001]. HCV infection is persistent in the majority of infected individuals, and carriers develop chronic liver disease with approximately 20% developing cirrhosis after 20 years [Lauer and Walker, 2001].…”

Section: Discussionsupporting

confidence: 93%

Influence of mutation of the HFE gene on the progression of chronic viral hepatitis B and C in Moroccan patients

Ezzikouri

Rebbani

Ababou

et al. 2011

Journal of Medical Virology

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The implication of hemochromatosis (HFE) gene mutations in chronic viral hepatitis remains controversial. The aim of the present study was to measure the frequencies of the common HFE gene mutations in Moroccan subjects with chronic viral hepatitis B and C and to assess their influence on the progression of liver disease. H63D and C282Y mutations were screened by the polymerase chain reaction followed by restriction fragment length polymorphism analysis in 170 chronic hepatitis B patients, 168 chronic hepatitis C patients, and 200 healthy controls. A very small proportion of patients infected with hepatitis B virus (HBV) or hepatitis C virus (HCV; 1.8% and none, respectively) were heterozygous for the C282Y mutation, that is, rates not statistically different from those observed in healthy control (2%, P > 0.05). Similarly, the frequency of the H63D allele was not significantly different between HBV (13.8%) or HCV (14.3%) patients and controls (13.5%, P > 0.05). Multivariate analysis showed that carriers of the H63D mutation infected with HBV are at higher risk to progress towards an advanced liver disease when compared with patients infected with HBV with wild-type (OR = 2.45, 95% CI = 1.07-5.58). In contrast, no association between HFE mutated HCV-infected patients and an increased risk of disease progression was found (OR = 1.24, 95% CI = 0.61-2.50, P = 0.547). In conclusion, in Morocco the frequency of the HFE C282Y allele is very low and H63D mutation carriage occurs in almost 14% of the patients, a rate similar in chronic hepatitis patients and healthy controls. In the case of chronic hepatitis B, the carriage of the H63D variant represents a risk factor of evolution towards a more active disease.

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Section: Discussionsupporting

confidence: 93%

Influence of mutation of the HFE gene on the progression of chronic viral hepatitis B and C in Moroccan patients

Ezzikouri

Rebbani

Ababou

et al. 2011

Journal of Medical Virology

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“…For example, a study on liver biopsy material from Italy found no C282Y homozygotes among 63 males with hepatocellular carcinoma. 10 Given the low frequency of this mutation in that region of Italy, this nding is consistent with expectation. The effect of variations in population-level exposures to other agents, such as alcohol and hepatitis viruses, on the relative frequency of C282Y-related hepatocellular carcinoma is more dif cult to determine.…”

Section: Discussionsupporting

confidence: 90%

Original Paper: Hereditary haemochromatosis and hepatocellular carcinoma in males: a strategy for estimating the potential for primary prevention

et al. 2003

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“…While some authors found a higher prevalence of HFE gene mutations in patients with liver cirrhosis and HCC in comparison to a normal population [114] and in comparison to patients with liver cirrhosis and no HCC (12.4 vs. 3.7%) [115] , others were not able to confirm these findings.…”

Section: Hemochromatosis Iron Overload and Hccmentioning

confidence: 88%

Hepatocellular Carcinoma – Epidemiological Trends and Risk Factors

Schütte

Bornschein

Malfertheiner

2009

Dig Dis

389

218

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Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide with about 600,000 patients dying from the disease annually. In 70–90%, HCC develops on the background of chronic liver cirrhosis or inflammation. Risk factors and etiologies vary among geographical regions. In regions with a high incidence the majority of cases are related to HBV and HCV hepatitis. In developed countries, in addition to virus-related HCC, high consumption of alcohol as well as non-alcoholic fatty liver disease often in the context of metabolic syndromes are the prevalent causes. Improvement in clinical management of patients with liver cirrhosis and the control of related complications are the key for the rising incidence of HCC. This review gives an overview on epidemiological trends and risk factors and their mechanisms involved in the hepatocarcinogenesis. Knowledge of these factors will help to improve current concepts for prevention, screening and treatment of this disease.

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Mutations in the HFE Gene and Their Interaction with Exogenous Risk Factors in Hepatocellular Carcinoma

Cited by 39 publications

References 28 publications

Influence of mutation of the HFE gene on the progression of chronic viral hepatitis B and C in Moroccan patients

Influence of mutation of the HFE gene on the progression of chronic viral hepatitis B and C in Moroccan patients

Original Paper: Hereditary haemochromatosis and hepatocellular carcinoma in males: a strategy for estimating the potential for primary prevention

Hepatocellular Carcinoma – Epidemiological Trends and Risk Factors

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