2009
DOI: 10.1016/j.nbd.2008.10.013
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Mutant γPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells

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Cited by 58 publications
(94 citation statements)
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References 63 publications
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“…We constructed two types of adenoviral vectors to express FLAG-SERT under the regulation of tetracycline (32,33). The first vector expresses the tetracycline transactivator (tTA) under the control of the cytomegalovirus (CMV) promoter (Ad-CMV-tTA).…”
Section: Generation Of Plasmids and Adenoviral Vectorsmentioning
confidence: 99%
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“…We constructed two types of adenoviral vectors to express FLAG-SERT under the regulation of tetracycline (32,33). The first vector expresses the tetracycline transactivator (tTA) under the control of the cytomegalovirus (CMV) promoter (Ad-CMV-tTA).…”
Section: Generation Of Plasmids and Adenoviral Vectorsmentioning
confidence: 99%
“…The experimental procedures are summarized in our previous report (32,33 3 H]5-HT was stopped by washing three times with cold KRH buffer containing 10 M fluvoxamine, and the cells were then lysed with RIPA buffer (10 mM TrisHCl, 1% NP-40, 0.1% SDS, 0.1% sodium deoxycholate, 150 mM NaCl and 1 mM EDTA pH 7.4). The cell extracts were diluted in a scintillation cocktail (Clear-Sol II; Nakalai Tesque, Kyoto), and their radioactivity was measured with a liquid scintillation counter (LSC-5100; Aloka, Mitaka).…”
Section: Cell Culture and Transfectionmentioning
confidence: 99%
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“…We have previously demonstrated that mutant versions of γPKC form aggregates in cultured cells (19) and mouse primary cultured PCs (20), leading to apoptotic cell death (21). Furthermore, mutant γPKC forms soluble oligomers that have amyloid structure and induce improper development of PC dendrites (20).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, mutant γPKC forms soluble oligomers that have amyloid structure and induce improper development of PC dendrites (20). Amyloid oligomers and fibrils caused by mutant or misfolded proteins are also Tanaka 1 frequently observed in various neurodegenerative diseases, including Alzheimer's, Parkinson's, and polyglutamine diseases (22,23), which suggests that aggregation is a common component of the pathogenesis of neurodegenerative diseases like SCA14.…”
Section: Introductionmentioning
confidence: 99%