Mutant p53 inhibits helicobacter-induced premalignant lesions through downregulation of Th1 proinflammatory responses

Fox, James G.; Sheppard, Barbara J.; Dangler, Charles A.; Whary, Mark T.; Ihrig, Melanie; Wang, Yichen

doi:10.1016/s0016-5085(08)80426-x

Cited by 18 publications

(30 citation statements)

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“…This idea is supported by the high incidence (~80%) of gastric cancer development in mice infected with Helicobacter felis, which provokes strong inflammation in the stomach. 42,43 The incidences of benign tumors in the gastrointestinal tracts of cagA Hs -ABCCC mice and cagA Hs -ABDD mice were 4.0% and 11.0%, respectively. Approximately 2.0% of cagA Hs -ABCCC mice developed gastrointestinal and hematopoietic malignancies, whereas 9.1% of cagA Hs -ABDD mice developed gastrointestinal and hematopoietic malignancies.…”

Section: Discussionmentioning

confidence: 99%

Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice

Miura

Ohnishi

Tanaka

et al. 2009

Intl Journal of Cancer

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BACKGROUND: The value of local treatment in patients with primary, disseminated, multifocal Ewing sarcoma (PDMES) was investigated. METHODS: We analyzed 120 patients registered into the European Ewing Tumor Working Initiative of National Groups (EURO‐E.W.I.N.G. 99) trial at the trial center of Muenster from 1998 to 2006. Median age was 16.2 years. Local treatment of the primary tumor was surgery in 26 of 120 patients, surgery and radiotherapy in 21 patients, and definitive radiotherapy in 40 patients. For treatment of metastases, 6 of 120 patients received surgery; 9 patients, surgery and radiotherapy; and 33 patients, definitive radiotherapy. Forty‐seven (39%) patients had local treatment of both the primary tumor and metastases, 41 (34%) patients of either the primary tumor or metastases, and 32 (27%) received no local therapy. RESULTS: Event‐free survival (EFS) at 3 years was 0.24 (95% CI, 0.16‐0.33). Univariate analyses demonstrated the impact of local therapy given to the primary tumor: 3‐year EFS was 0.25 with surgery, 0.47 with surgery and radiotherapy, 0.23 with radiotherapy, and 0.13 when no local therapy was administered (P < .001). Three‐year EFS in PDMES was also influenced by the local treatment: surgery, 0.33; surgery and radiotherapy, 0.56; radiotherapy, 0.35; no local therapy, 0.16 (P = .003). Three‐year EFS was 0.39 in patients who received local treatment of both primary tumor and PDMES, compared with 0.17 in patients with any local treatment of either primary tumor or PDMES and 0.14 in patients with no local therapy (P < .001). Multivariate analysis showed absence of local treatment to be the major risk factor (HR = 2.21; P = .027; n = 20). CONCLUSIONS: Local therapy of involved sites is important for patients with PDMES and should complement systemic treatment whenever possible. Cancer 2010. © 2010 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice

Miura

Ohnishi

Tanaka

et al. 2009

Intl Journal of Cancer

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“…In mice with hemizygous deletion of p53, a paradoxical protective effect is observed against the progression of H. felis-induced gastric tumorigenesis, attributable in part to depressed T h 1 immune responses (9). As with humans, chemotherapeutic immune suppression decreases Helicobacter-induced gastric lymphoepithelial lesions in mice.…”

Section: Infectious Stomach Cancermentioning

confidence: 98%

“…The murine pathogen H. felis induces severe gastritis that can lead to adenocarcinoma in C57BL mice (9). In mice with hemizygous deletion of p53, a paradoxical protective effect is observed against the progression of H. felis-induced gastric tumorigenesis, attributable in part to depressed T h 1 immune responses (9).…”

Section: Infectious Stomach Cancermentioning

confidence: 99%

Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer

Rogers

Fox

2004

American Journal of Physiology-Gastrointestinal and Liver Physi

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112

101

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Chronic gastrointestinal and liver infections account for a significant percentage of human cancer deaths. Rodent models help elucidate how infection can lead to malignancy. Helicobacter pylori, the leading cause of human gastric tumors, produces similar disease in Mongolian gerbils. H. pylori, H. felis, and H. hepaticus induce stomach, lower bowel, or liver tumors in susceptible wild-type and genetically engineered mice. Immune dysregulated mice recapitulate features of inflammatory bowel disease including colon carcinoma. Hepatitis B and C virus transgenic mice provide insights into viral hepatitis and hepatocellular carcinoma. Rodent models enhance our understanding of infectious cancer pathogenesis and suggest novel targets for intervention.

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“…Recently, IL-10 has been implicated in resistance to apoptosis in lung cancer [72]. p53 is an important tumor suppressor having inhibitory activity on IL-10 [73]. High IL-10 production is also observed in lymphocytes from p53-deficient mice with experimental autoimmune encephalomyelitis [74].…”

Section: Il-10 and Cancermentioning

confidence: 99%

Role of interleukin-10 in breast cancer

Ullah

Changkija

Konwar

2011

Breast Cancer Res Treat

153

113

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Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the intensity and duration of immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of target cells. Different cytokines are known to have diverse role in breast cancer initiation and progression. Interleukin-10 (IL-10), a pleiotropic anti-inflammatory cytokine, induces immunosuppression and assists in escape from tumor immune surveillance. Like several other cytokines, IL-10 also can exert dual proliferative and inhibitory effect on breast tumor cells indicating a complex role of IL-10 in breast cancer initiation and progression. In this review, we tried to put together a comprehensive current view on significance of IL-10 in promotion, inhibition, and importance as prognosticator in breast cancer based on in vitro, in vivo, and clinical evidences. For literature collection, we conducted PubMed search with keywords "IL-10" and "breast cancer".

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Mutant p53 inhibits helicobacter-induced premalignant lesions through downregulation of Th1 proinflammatory responses

Cited by 18 publications

References 0 publications

Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice

Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice

Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer

Role of interleukin-10 in breast cancer

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