2011
DOI: 10.1007/s10549-011-1855-x
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Role of interleukin-10 in breast cancer

Abstract: Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the intensity and duration of immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of target cells. Different cytokines are known to have diverse role in breast cancer initiation and progression. Interleukin-10 (IL-10), a pleiotropic anti-inflammatory cytokine, induces immunosuppression and assists in escape from tumor immune surveillance. Like several other cytokines, IL-10 also … Show more

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Cited by 155 publications
(122 citation statements)
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“…On the other hand, IL10 also exhibits tumour inhibiting antiangiogenic action [6,7]. This dual nature of IL 10 complicates any attempt to manage breast cancer with IL10 as therapeutic target [5], and it's an area for further research.…”
Section: Follow Upmentioning
confidence: 99%
See 1 more Smart Citation
“…On the other hand, IL10 also exhibits tumour inhibiting antiangiogenic action [6,7]. This dual nature of IL 10 complicates any attempt to manage breast cancer with IL10 as therapeutic target [5], and it's an area for further research.…”
Section: Follow Upmentioning
confidence: 99%
“…Interleukin 10 (IL10) is a cytokine secreted by almost all leukocytes including T cells, monocytes, macrophages, keratinocytes and by tumour cells [4,5]. It plays a dual role on cancer pathogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…This suggests that hypoxia of the tumor microenvironment may promote metastasis through the synergistic effect of HIF-1α and proinflammatory mediators. In addition to proinflammatory cytokines and chemokines, immunosuppressive molecules such as TGF-β, IL-10, and PGE2 are often present in abundant levels in the tumor microenvironment (Wrzesinski et al, 2007;Chen and Smyth, 2011;Hamidullah et al, 2012;Basu et al, 2013). Other suppressive factors produced by breast cancer cells, such as soluble forms of the ligand, soluble major histocompatibility complex class I-relatedchain A (sMICA) and IDO, have also been shown to suppress antitumor NK cells and CD8 + T cells (Groh et al, 2002;Uyttenhove et al, 2003;Muller et al, 2005).…”
Section: Proinflammatory Cytokines and Chemokinesmentioning
confidence: 99%
“…Interleukins are regulatory proteins that modulates immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of target cells. Different Interleukins are known to have diverse role in breast cancer initiation and progression [4].…”
Section: Introductionmentioning
confidence: 99%