Mutagenicity screening of foods. II. Results with fruits and vegetables

Stoltz, D.R.; Stavrić, B.; Stapley, Ryan; Klassen, R.; Bendall, R.; Krewski, Daniel

doi:10.1002/em.2860060310

Cited by 17 publications

(8 citation statements)

References 33 publications

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“…31,62,63,[70][71][72][73][74][75][76] In vitro, mixed results were reported in the genotoxicity of vitis vinifera (grape)-derived ingredients, but in vivo, mostly negative results were obtained (Table 10). Fractions of raw grapes demonstrated potent mutagenic activity in an Ames test, 70 and water and ethanol extracts of red and white grapes enhanced mitomycin-C (MMC)-induced sister chromatid exchanges (SCEs) in an SCE assay in human lymphocytes, but there was no effect on SCEs without MMC. 31 Grape juice was also mutagenic in vitro, as demonstrated in the Ames test.…”

Section: Genotoxicitymentioning

confidence: 99%

Safety Assessment of Vitis vinifera (Grape)-Derived Ingredients as Used in Cosmetics

Fiume¹,

Bergfeld²,

Belsito³

et al. 2014

Int J Toxicol

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The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 24 Vitis vinifera (grape)-derived ingredients and found them safe in the present practices of use and concentration in cosmetics. These ingredients function in cosmetics mostly as skin-conditioning agents, but some function as antioxidants, flavoring agents, and/or colorants. The Panel reviewed the available animal and clinical data to determine the safety of these ingredients. Additionally, some constituents of grapes have been assessed previously for safety as cosmetic ingredients by the Panel, and others are compounds that have been discussed in previous Panel safety assessments.

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Section: Genotoxicitymentioning

confidence: 99%

Safety Assessment of Vitis vinifera (Grape)-Derived Ingredients as Used in Cosmetics

Fiume¹,

Bergfeld²,

Belsito³

et al. 2014

Int J Toxicol

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“…The scientific reports assessing the genotoxic potential of phytocomplexes gave indeed controversial results in terms of safety and mutagenicity of grape-derived ingredients. In 1982 and 1984 Stoltz and colleagues [ 44 , 45 ] analyzed the mutagenic potential of a wide variety of food and food products by means of the Ames test. In their surveys, components of polar fractions of raw grapes and grape juice demonstrated potent mutagenic activity, both in the presence and absence of metabolic activation.…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity Assessment of Three Nutraceuticals Containing Natural Antioxidants Extracted from Agri-Food Waste Biomasses

Badolati

Masselli

Maisto

et al. 2020

Foods

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Grapes and apples are the most cultivated fruits in the Mediterranean basin and their agricultural processing is responsible for the production of a large amount of bio-waste. The reuse of this food biomass would increase the volume of recyclable/renewable biomaterial and lower the environmental impact due to the increasing demand for these biological products. To this purpose, agri-food waste from grape and apple processing have become an important source of phytochemicals, and many pharmaceutical industries are using it as starting material to produce dietary supplements, functional foods, and food additives for human consumption. In virtue of the chemical diversity and complexity of agri-food biowaste, developers and producers of nutraceuticals are advised to assess the safety of their final nutraceutical products, in compliance with European Food Safety Authority regulation. Here, we use the Ames test to assess the mutagenicity of three nutraceuticals obtained from agri-food waste biomasses: Taurisolo® from grape pomace of Vitis vinifera L. cv ‘Aglianico’, AnnurComplex® from Malus pumila M. cv ‘Annurca’ and Limoncella Apple Extract from Malus domestica B. cv ‘Limoncella’. The results showed that all three nutraceuticals were non-mutagenic.

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“…The results of mutagenicity studies of Q-Actin, as evaluated by bacterial reverse mutation test (Ames assay), in vitro chromosomal aberration assay and in vivo micronucleus test in Swiss albino mice, did not reveal any genotoxic effects. In an earlier study, Stoltz et al [ 23 ] reported that an extract of cucumber in an Ames test using S. typhimurium TA98 and TA100 with and without metabolic activation was not mutagenic. The findings from the present study support these observations.…”

Section: Discussionmentioning

confidence: 99%

Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

Kothari¹,

Saravana²,

Muthusamy³

et al. 2018

Toxicology Reports

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Cucumus sativus (cucumber) is one of the most widely consumed fruit vegetables worldwide. Recent discovery of iminosugars in commonly consumed fruits and vegetables has promoted the interest in isolating these compounds and understanding the potential benefits to human health. The objective of the present study was to investigate the general toxicity and mutagenic effects of an aqueous extract of cucumber (Q-Actin), standardized to ≥1% (1–2%) ido-BR1 iminosugar. Single dose of Q-Actin was well tolerated without mortality at 2000 mg/kg body weight (bw) in Sprague Dawley rats. Oral (gavage) administration of Q-Actin up to 1000 mg/kg bw/day was well tolerated followed by repeated administration for a maximum period of 90 days in Sprague-Dawley rats. There were no treatment related changes in clinical observations, ophthalmic examinations, body weights and body weight gains or feed consumption, clinical chemistry and pathological changes compared to control. The mutagenicity as evaluated by Ames assay, in vitro chromosomal aberration test and in vivo micronucleus assay did not reveal any potential of Q-Actin to induce genotoxicity. The results showed that Q-Actin is well tolerated in general toxicity studies and did not induce mutagenicity. The no-observed-adverse-effect level (NOAEL) of the standardized aqueous cucumber extract (Q-Actin) is considered to be ≥1000 mg/kg bw/day, followed by repeated administration for90 days.

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Mutagenicity screening of foods. II. Results with fruits and vegetables

Cited by 17 publications

References 33 publications

Safety Assessment of Vitis vinifera (Grape)-Derived Ingredients as Used in Cosmetics

Safety Assessment of Vitis vinifera (Grape)-Derived Ingredients as Used in Cosmetics

Genotoxicity Assessment of Three Nutraceuticals Containing Natural Antioxidants Extracted from Agri-Food Waste Biomasses

Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

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