Mutagenicity of wood smoke condensates in the Salmonella/microsome assay

Asita, A.O.; Matsui, Michiko; Nohmi, Takehiko; Matsuoka, Atsuko; Hayashi, Makoto; Ishidate, Motoi; Sofuni, Toshio; Koyano, Michiko; Matsushita, Hidetsuru

doi:10.1016/0165-7992(91)90039-7

Cited by 31 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wood smoke resembles the cigarette smoke in several of its contents and contains PAHs, and it has been reported that B(a)P (a congener of PAHs family) intake via biomass smoke is analogous to smoking several packs of cigarettes (Nalte et al 2001;Asita et al 1991). It is estimated that combustion of 1 kg wood emits about 1 mg B(a)P (Singh et al 2013 and reference therein), and total native PAHs in coal can be found in concentration of hundreds to thousands of milligrams per kilogram (Claxton 2014); the total suspended particles emitted from two packs of cigarette is 40 mg/m 3 (Dockery and Spengler 1981), whereas that from indoor biomass smoke is 10,000 mg/m 3 , which is many folds higher (Pandey et al 1989).…”

Section: Pahs Biomarkers Of Exposure and Effectsmentioning

confidence: 99%

A review of PAH exposure from the combustion of biomass fuel and their less surveyed effect on the blood parameters

Kamal

Cincinelli

Martellini

et al. 2014

Environ Sci Pollut Res

117

View full text Add to dashboard Cite

Many epidemiological studies from all over the world have reported that populations of rural and urban environments differ in their health issues due to the differences in the countrywide pollution pattern. In developing countries, various occupational cohorts and subsections of the population in urban and rural areas are routinely exposed to several environmentally widespread contaminants. Polycyclic aromatic hydrocarbons (PAHs) are a group of over hundred different compounds and have ubiquitous presence in rural and urban environments. Smoke from the combustion of biomass fuel contains a high concentration of carcinogenic PAHs, which are related with several human morbidities. The sources and types of biomass fuel are diverse and wide in distribution. Limited numbers of literature reports have focused the significant impact of PAHs on several components of blood, both in human and wildlife. The toxicity of PAHs to rapidly dividing cells (e.g., bone marrow cells) and other tissues is largely attributed to their reactive oxygenated metabolites, potential of causing oxidative stress, and the adducts of their metabolites with DNA. This review aims to encompass the blood-related effects of PAHs and associated human health risks-an aspect that needs further research-on the population of developing countries of the world in particular.

show abstract

Section: Pahs Biomarkers Of Exposure and Effectsmentioning

confidence: 99%

A review of PAH exposure from the combustion of biomass fuel and their less surveyed effect on the blood parameters

Kamal

Cincinelli

Martellini

et al. 2014

Environ Sci Pollut Res

117

View full text Add to dashboard Cite

show abstract

“…M.ixtures of these PAH in concentrations typical of the smoke condensates did not induce mutations. (Asita et al 1991) This does not necessarily absolve the PAH, since it has been reported that the addition of BaP to a tobacco tar did not increase its tumorigenic activity either, whereas a mixture of 17 P AH present in tobacco tars did so. (Wynder and Huffinann1968) Only a few of the PAR are implicated as mutagens or carcinogens (IARC 1996).…”

mentioning

confidence: 99%

A review of the toxicity of biomass pyrolysis liquids formed at low temperatures

Diebold¹

1997

View full text Add to dashboard Cite

“…For instance, glyphosate alone rarely caused genetic damage in laboratory tests whereas roundup, a glyphosate product, was mutagenic (Rank et al, 1993). The mutagenic effects of the condensates of wood smoke have been demonstrated in S. typhimurium reverse mutation assays (Nagao et al, 1977;Kamens et al, 1984;Asita et al, 1991) and mutagenic polycylic aromatic hydrocarbons (PAHs) were detected in African smoked fish (Mossanda et al, 1979). All the three concentrations of Eriocephalus punctulatus smoke condensate (EPSC) tested in the present study with Allium cepa root tip meristem cells induced genotoxicity.…”

Section: Discussionmentioning

confidence: 80%

Clastogenic and Cytotoxic Effects of Four Pesticides Used to Control Insect Pests of Stored Products on Root Meristems of Allium cepa

Asita¹,

Mokhobo²

2013

ENRR

View full text Add to dashboard Cite

While the use of pesticides of stored product has increased productivity in agriculture, there is concern about their use because some are mutagens and/or carcinogens, harm non-target organisms or cause pest resistance. In this study Grain Treat (GT) (Mercaptothion, 10 g kg -1 , Permethrin 1.5 g kg -1 ); QuickPhos (QP) (Aluminium Phosphide, 560 g kg -1 ); Nuvan Profi (NP) (Dichlorvos, 124 g kg) and Eriocephalus punctulatus plant smoke condensate (EPSC) were evaluated for cytotoxicity and the induction of genotoxicity in the onion (Allium cepa) test. Onion seeds were germinated and exposed to pesticides (mg ml -1 ), GT (12.5, 25, 50); QP (0.75, 1.5, 3.0); NP (0.064, 0.128, 0.256); EPSC (0.0025, 0.0049, 0.0098) for 24 hours. For each concentration, three root tips were transferred to three microscope slides, stained with aceto-carmine, covered with cover slip, squashed and observed microscopically. The cytotoxicity and genotoxicity induced by each pesticide concentration was compared with the value for the concomitant negative control using t-test. Only QP (3.0 mg mL -1 ) and NP (0.256 mg mL -1 ) significantly depressed the MI, i.e. cytotoxic (P < 0.05). Genotoxicity was determined by examining, 100 anaphase and telophase cells on each of three slides per concentration for chromosome aberration (CA). The three concentrations of each pesticide induced CAs (P < 0.05) in the following general order of frequency; stickiness > multipolarity > c-mitosis > anaphase and telophase bridges > chromosome Largards. The induction of sticky chromosomes indicated that the pesticides caused abnormal DNA condensation, abnormal chromosome coiling and inactivated the spindles. Because abnormalities of the cell division process results from the genotoxic effects of environmental chemicals, the four pesticides have the potential to cause aneuploidy in exposed organisms and adverse human health and environmental effects.

show abstract

Mutagenicity of wood smoke condensates in the Salmonella/microsome assay

Cited by 31 publications

References 19 publications

A review of PAH exposure from the combustion of biomass fuel and their less surveyed effect on the blood parameters

A review of PAH exposure from the combustion of biomass fuel and their less surveyed effect on the blood parameters

A review of the toxicity of biomass pyrolysis liquids formed at low temperatures

Clastogenic and Cytotoxic Effects of Four Pesticides Used to Control Insect Pests of Stored Products on Root Meristems of Allium cepa

Contact Info

Product

Resources

About