Mutagenicity of acrylonitrile

Meester, Conrad De; Poncelet, F.; Roberfroid, Marcel; Mercier, Michel

doi:10.1016/s0300-483x(78)90239-1

Cited by 52 publications

(10 citation statements)

References 13 publications

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“…Acrylonitrile is a known carcinogen in animals and a suspected carcinogen in man and was previously reported as mutagenic when tested as a gas [9] . In structure, it is similar to vinyl chloride, which is a known carcinogen for man and animals [ 101 .…”

Section: Discussionmentioning

confidence: 99%

Mutagenicity of vinyl compounds in salmonella typhimurium

Lijinsky

Andrews

1981

Teratog Carcinog Mutagen

150

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Eighteen compounds structurally related to the mutagenic carcinogen vinyl chloride have been tested for mutagenicity in five strains of Salmonella typhimurium. Acrolein, acrolein diethylacetal, acrylonitrile, allyl alcohol, allyl bromide, crotonaldehyde, crotyl alcohol, and vinyl bromide were mutagenic with one or more strains; acrolein bisulfite, acrolein oxime, acrylamide, acrylic acid, allylamine, trans-cinnamaldehyde, trans-cinnamic acid, crotonic acid, methyl methacrylate, and vinyl acetate were not mutagenic. The mutagenicity tests were performed both without and with activation by rat and hamster liver microsomal preparations (S9). All compounds were tested in the plate incorporation and/or liquid preincubation tests except vinyl bromide, which was tested as a gas.

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Section: Discussionmentioning

confidence: 99%

Mutagenicity of vinyl compounds in salmonella typhimurium

Lijinsky

Andrews

1981

Teratog Carcinog Mutagen

150

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“…In studies involving bacterial mutagenicity, butadiene has been shown to be a base-pair mutagen in Salmonella typhimurium strains TA1530 and 1535 (23). Its mutagenicity requires metabolic activation (24).…”

Section: Toxicitymentioning

confidence: 99%

A brief survey of butadiene health effects: a role for metabolic differences.

Birnbaum

1993

Environ Health Perspect

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1,3-Butadiene is a major monomer in the rubber and plastics industry and is one of the highest-production industrial chemicals in the United States. Although not highly acutely toxic to rodents, inhalation of concentrations as low as 6.25 ppm causes tumors in mice. Butadiene is oncogenic in rats, but much higher exposure concentrations are required than in mice. Chronic toxicity targets the gonads and hematopoetic system. Butadiene is also a potent mutagen and clastogen. Differences in the absorption, distribution, and elimination of butadiene appear to be relatively minor between rats and mice, although mice do retain more butadiene and its metabolites after exposure to the same concentration and have a higher rate of metabolic elimination. Recent studies have demonstrated that major species differences appear to occur in the rate of detoxication of the primary metabolite, 3-epoxybutene (butadiene monoepoxide [BDMO]). Mice have the greatest rate of production of BDMO as compared to other species, but the rate of removal of BDMO appears to be less than in other species. Mice have low levels of epoxide hydrolase; rats have intermediate levels; monkeys and humans appear to have high levels of this detoxifying enzyme. Thus, while only low levels of butadiene exposure may result in an accumulation of BDMO in the mouse, much higher levels would be required to result in an elevation of circulating BDMO in other species. The level of this reactive metabolite may be correlated with the species differences in butadiene sensitivity.

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“…Of all the commercial nitriles, ACN is manufactured on the largest scale. Adverse effects of ACN on human health and the environment are well documented [4,7,24,26,31]. The current US EPA recommendation for ACN in lakes and streams is \0.058 ppb to prevent possible health effects [1].…”

Section: Introductionmentioning

confidence: 99%

Laboratory-scale biofiltration of acrylonitrile by Rhodococcus rhodochrous DAP 96622 in a trickling bed bioreactor

Zhang

Pierce

2009

J Ind Microbiol Biotechnol

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Acrylonitrile (ACN), a volatile component of the waste generated during the production of acrylamide, also is often associated with aromatic contaminants such as toluene and styrene. Biofiltration, considered an effective technique for the treatment of volatile hydrocarbons, has not been used to treat volatile nitriles. An experimental laboratory-scale trickling bed bioreactor using cells of Rhodococcus rhodochrous DAP 96622 supported on granular activated carbon (GAC) was developed and evaluated to assess the ability of biofiltration to treat ACN. In addition to following the course of treatability of ACN, kinetics of ACN biodegradation during both recycle batch and open modes of operation by immobilized and free cells were evaluated. For fed-batch mode bioreactor with immobilized cells, almost complete ACN removal (>95%) was achieved at a flow rate of 0.1 microl/min ACN and 0.8 microl/min toluene (TOL) (for comparative purposes this is equivalent to 6.9 mg l(-1) h(-1) ACN and 83.52 mg l(-1) h(-1) TOL). In a single-pass mode bioreactor with immobilized cells, at ACN inlet loads of 100-200 mg l(-1) h(-1) and TOL inlet load of approximately 400 mg l(-1) h(-1), with empty bed retention time (EBRT) of 8 min, ACN removal efficiency was approximately 90%. The three-dimensional structure and characteristics of the biofilm were investigated using confocal scanning laser microscopy (CSLM). CLSM images revealed a robust and heterogeneous biofilm, with microcolonies interspersed with voids and channels. Analysis of the precise measurement of biofilm characteristics using COMSTAT agreed with the assumption that both biomass and biofilm thickness increased along the carbon column depth.

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Mutagenicity of acrylonitrile

Cited by 52 publications

References 13 publications

Mutagenicity of vinyl compounds in salmonella typhimurium

Mutagenicity of vinyl compounds in salmonella typhimurium

A brief survey of butadiene health effects: a role for metabolic differences.

Laboratory-scale biofiltration of acrylonitrile by Rhodococcus rhodochrous DAP 96622 in a trickling bed bioreactor

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