Mutagenicity of vinyl compounds in salmonella typhimurium

Lijinsky, William; Andrews, A. W.

doi:10.1002/tcm.1770010303

Cited by 150 publications

(37 citation statements)

References 14 publications

(10 reference statements)

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“…AN is metabolized to CEO, Table 2 Summary of exposure-response data for brain tumors in rats following oral and inhalation exposures to AN a Peak concentration of CEO in brain as predicted by a PBPK model which has been implicated in its ability to react with DNA bases in vitro to form adducts (Whysner et al, 1998a), and to produce mutations at high concentrations in vitro (Lijinsky and Andrews, 1980;Venitt et al, 1977;Zeiger and Haworth, 1985). Phosphodiester adducts were observed in an in vitro study using high concentrations of CEO (Yates et al, 1994).…”

Section: Data From Mechanistic Studiesmentioning

confidence: 99%

Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity

Kirman

Gargas

Marsh

et al. 2005

Regulatory Toxicology and Pharmacology

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Section: Data From Mechanistic Studiesmentioning

confidence: 99%

Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity

Kirman

Gargas

Marsh

et al. 2005

Regulatory Toxicology and Pharmacology

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“…The mutagenicity of acrolein is not well understood because reported results show positive (22,230,265,275), marginal (229,276,277), and negative (278-280) findings for different cell strains.…”

Section: Genetic and Related Cellular Effects Studiesmentioning

confidence: 80%

Aldehydes and Acetals

Borchers¹

2012

Patty's Toxicology

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More than 300 aldehydes occur in foods, water, and air. Due to the electrophilicity of the carbonyl carbon, particularly when proximal to a carbon–carbon double bond, aldehydes react with thiols and amines to form protein–protein, DNA–protein, and DNA–DNA cross‐links. Despite their potential for causing cell damage, toxicological and exposure data for a large number of aldehydes are lacking. Inhalation and ingestion studies have demonstrated that a number of aldehydes are irritants and can induce tumors in animal models. Formaldehyde, which is a suspected carcinogen, is the most widely studied of these compounds. The physicochemical properties of saturated aldehydes are summarized. Toxicological and health effects are given.

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“…Reverse mutation S. typhimurium TA1537, TA92, TA94, TA98, TA100, TA1535 (with plate incorporation and preincubation) 500 µg/plate Negative a (Lijinsky & Andrews, 1980) Valid.…”

Section: Insufficient Insufficient Validity (Eg If Main Aspects Arementioning

confidence: 99%

Flavouring Group Evaluation 214: alpha, beta‐Unsaturated aldehydes and precursors from chemical subgroup 3.1 of FGE.19: Cinnamyl derivatives

2009

EFS2

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. 739 and 09.780]. The configuration of the double bond in cinnamaldehyde .014] has not been specified. However, the substance is anticipated to contain more than 97 % trans-cinnamaldehyde.Some concern could be raised by studies carried out with cinnamaldehyde , showing an ability to induce chromosomal damage in vitro and by the positive result obtained for 2-methoxycinnamaldehyde .048] in an Ames test. For cinnamaldehyde the concern was not confirmed in in vivo studies. Thus, it is concluded that cinnamaldehyde does not have a genotoxic potential in vivo. In addition, the carcinogenicity studies with trans-cinnamaldehyde did not indicate a carcinogenic potential.The ring substituents (4-methyl, 4-hydroxy, 4-methoxy, 3-or 5-methoxy or 2-methoxy) are anticipated not to increase but rather decrease the reactivity of the alpha,beta-unsaturated aldehyde group. Therefore, the Panel concluded that the seven ring substituted cinnamyl derivatives 05.051, 05.118, 05.122, 05.154, 05.155 and 09.306], like the unsubstituted cinnamyl derivatives, were not of concern with respect to genotoxicity.The Panel concluded that the data available do not preclude an evaluation of the alpha,betaunsaturated cinnamaldehyde-derivatives in FGE.214 (subgroup 3.1 of FGE.19) using the Procedure.

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Mutagenicity of vinyl compounds in salmonella typhimurium

Cited by 150 publications

References 14 publications

Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity

Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity

Aldehydes and Acetals

Flavouring Group Evaluation 214: alpha, beta‐Unsaturated aldehydes and precursors from chemical subgroup 3.1 of FGE.19: Cinnamyl derivatives

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