Mutagenicity, Genotoxicity, and Estrogenic Activity of River Porewaters

Parrella, Alfredo; Lavorgna, Margherita; Criscuolo, Emma; Isidori, Marina

doi:10.1007/s00244-013-9928-y

Cited by 9 publications

(7 citation statements)

References 46 publications

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“…These results were consistent with the results obtained by analysis of fish bile extracts on field‐caught fish from the Xin'an River, which had lower EDC levels than the market sold fish in Shanghai. It has been reported that the estradiol equivalent values of surface water from some rivers in France range from 0.3 ng/L to 4.52 ng/L , ND to 3.1 ng/L in Italy , and 0.7 ng/L to 4.01 ng/L in Japan , similar to the results of water from the Xin'an River in the present study.…”

Section: Resultssupporting

confidence: 90%

Chemical analysis of fish bile extracts for monitoring endocrine disrupting chemical exposure in water: Bisphenol A, alkylphenols, and norethindrone

Pan

Yang

et al. 2015

Enviro Toxic and Chemistry

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The present study determined concentrations of estrogenic bisphenol A (BPA), nonylphenol, octylphenol (4-tert-octylphenol), butylphenol (4-tert-butylphenol), and progestogenic norethindrone by liquid chromatography-tandem mass spectrometry in bile extracts from field fish from the Xin'an River and market fish in Shanghai, China. Compared with the field fish, endocrine disrupting chemical (EDC) concentrations in market fish bile were at relatively high levels with high detectable rates. The average concentrations of BPA, nonylphenol, 4-tert-octylphenol, 4-tert-butylphenol, and norethindrone in field fish bile were 30.1 µg/L, 203 µg/L, 4.69 µg/L, 7.84 µg/L, and 0.514 µg/L, respectively; in market fish bile they were 240 µg/L, 528 µg/L, 76.5 µg/L, 12.8 µg/L, and 5.26 µg/L, respectively; and in the surface water of Xin'an River they were 38.8 ng/L, 7.91 ng/L, 1.98 ng/L, 2.66 ng/L, and 0.116 ng/L, respectively. The average of total estrogenic activity of river water was 3.32 ng/L estradiol equivalents. High bioconcentration factors (BCFs) were discovered for all 5 EDCs (≧998-fold) in field fish bile. Furthermore, the authors analyzed the BCF value of BPA in fish bile after 30-d exposure to environmentally relevant concentrations of BPA in the laboratory, and the analysis revealed that BCF in fish bile (BCF(Fish bile)) changed in an inverse concentration-dependent manner based on the log10-transformed BPA concentration in water. Strikingly, the data from the field study were well fitted within this trend. The data together suggested that analysis of fish bile extracts could be an efficient method for assessing waterborne EDCs exposure for aquatic biota.

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Section: Resultssupporting

confidence: 90%

Chemical analysis of fish bile extracts for monitoring endocrine disrupting chemical exposure in water: Bisphenol A, alkylphenols, and norethindrone

Pan

Yang

et al. 2015

Enviro Toxic and Chemistry

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“…In Italy, tomatoes are mainly cultivated in the South especially in Agro Nocerino Sarnese (Campania Region) since it is one of the most fertile Italian flatlands for tomato production (31x10 6 This area is unfortunately affected by adverse environmental factors in relation to the Sarno River and its tributaries. The Sarno River is indeed, the most polluted river in Europe due to anthropogenic activity and uncontrolled industrial and urban waste disposal [8,9]. Many studies have shown that the Sarno river is contaminated by Potentially Toxic Elements (PTEs).…”

Section: Introductionmentioning

confidence: 99%

“…Montuori and co-authors [10] demonstrated that this river contributes to the pollution of the Tyrrhenian Sea with metals and polycyclic aromatic hydrocarbons (PHA). In a study conducted by Parrella et al [9], it is stated that the porewaters of the Sarno basin showed mutagenic/genotoxic effects. Recently, Cicchella and collaborators [11,12] demonstrated that Sarno stream sediments are contaminated with chromium (Cr) from tanneries and from copper (Cu) released from agricultural activities.…”

Section: Introductionmentioning

confidence: 99%

Tomato plants (Solanum lycopersicum L.) grown in experimental contaminated soil: Bioconcentration of potentially toxic elements and free radical scavenging evaluation

et al. 2020

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Tomato is the most widespread vegetable crop in the world. In Italy, tomatoes are mainly cultivated in the South and in the Campania region, precisely in the area called Agro Nocerino-Sarnese. This flatland is affected by an extreme level of environmental degradation, especially related to the Sarno River, where concentrations of Potential Toxic Elements (PTEs) have been found to be higher than the maximum permitted level. The aim of this study was to determine the PTEs uptake by roots and their translocation to the aerial parts of the plants of two cultivars of tomatoes (Pomodoro Giallo and San Marzano Cirio 3). To the purpose, samples of the two cultivars were grown both in pots with experimentally contaminated soil containing: Cr or Cd or Pb at extremely high concentrations and in pots with uncontaminated soils (control). Additionally, the antioxidant properties of the cultivars selected grown on uncontaminated/contaminated soils were assessed. The results showed that Cd was the contaminant that most significantly interfered with the growth of both cultivars of tomato plants, whereas Pb caused lower phenotypical damage. Cd translocation from root to the organs of tomato plants was observed in both cultivars. Specifically, the total amount of Cd found in stems and leaves was higher in the Pomodoro Giallo (254.4 mg/ kg dry weight) than in the San Marzano Cirio 3 (165.8 mg/kg dry weight). Cd was the only PTE found in the fruits of both cultivars, with values of 6.1 and 3.9 mg/kg dry weight of Pomodoro Giallo and San Marzano Cirio 3, respectively. The fruits of tomato plants grown in PTEs-contaminated soil showed inhibition or stimulations of the radical scavenging activity compared to the fruits grown in uncontaminated soil. This study highlighted that, despite the relatively high experimental concentrations of PTEs, their translocation to the edible part was comparatively low or absent.

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“…Xenobiotics deposited in sediments can cause cyto‐ and genotoxic effects in aquatic biota. Cyto‐ and genotoxicity of natural sediments can be estimated in elutriate‐ or extract‐based tests , but when toxicants are insoluble or present in the solid phase (like long‐lived natural and artificial radionuclides), whole‐sediment contact tests (such as the Allium test or tests similar to it) are more suitable . Aquatic plants rooted in sediments can be considered as potential indicators for estimating cyto‐ and genotoxicity in whole‐sediment contact tests, because they are used as in situ indicators of genotoxicity of natural bottom sediment.…”

Section: Introductionmentioning

confidence: 99%

Use of the aquatic plant Elodea canadensis to assess toxicity and genotoxicity of Yenisei River sediments

Зотина

Трофимова

Medvedeva

et al. 2015

Enviro Toxic and Chemistry

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The toxicity, cytotoxicity, and genotoxicity of bulk sediments from the Yenisei River (Siberia, Russia) were estimated in laboratory bioassays based on several endpoints in the aquatic plant Elodea canadensis. The bottom sediment samples were collected in the Yenisei River upstream and downstream of the sources of chemical and radioactive contamination. The testing revealed different sensitivities of Elodea endpoints to the quality of the bottom sediment: weight of shoots < length of shoots < mitotic index < length of roots < percentage of abnormal cells. The response of the genotoxicity endpoint (percentage of cells with chromosome abnormalities in roots of Elodea) was the highest in sediments with chemical pollution, whereas the highest inhibition of toxicity endpoints (shoot and root length) occurred in sediments with the highest level of radioactive pollution. The extreme response of Elodea endpoints to the quality of certain sediment samples may be regarded as related to the possible presence of unknown toxicants. The results show that E. canadensis can be used as an indicator species in laboratory contact testing of bottom sediment. The responses of shoot and root length growth endpoints of Elodea can be recommended as basic sensitivity indicators of bottom sediment toxicity. Analysis of cells carrying abnormal chromosomes in the apical root meristem of Elodea can be performed optionally in the same test to assess the genotoxicity of sediments.

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Mutagenicity, Genotoxicity, and Estrogenic Activity of River Porewaters

Cited by 9 publications

References 46 publications

Chemical analysis of fish bile extracts for monitoring endocrine disrupting chemical exposure in water: Bisphenol A, alkylphenols, and norethindrone

Chemical analysis of fish bile extracts for monitoring endocrine disrupting chemical exposure in water: Bisphenol A, alkylphenols, and norethindrone

Tomato plants (Solanum lycopersicum L.) grown in experimental contaminated soil: Bioconcentration of potentially toxic elements and free radical scavenging evaluation

Use of the aquatic plant Elodea canadensis to assess toxicity and genotoxicity of Yenisei River sediments

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