Mutagenicity and polycyclic aromatic hydrocarbons associated with extractable organic matter from airborne particles ⩽10μm in southwest Mexico City

Organic Compound in Airborne Particles and their Genottoxic Effects in Mexico City

“…Recent studies have shown different responses as a function of their own biological mechanisms. In a study carried out in SW of MC, Villalobos-Pietrini et al (2006) observed that the mutagenicity of strain TA98+S9 did not correlate with the monthly concentration of PM 10 and of EOM, while strains TA98-S9 and YG1021 correlated well, which suggests that there exist different emission sources of direct and indirect pollutants. The same organic compounds selectively separated in less complex groups (Fig.…”

“…The permissible limits are restricted to mass concentrations and should be important to relate those compounds with mutagenic and carcinogenic effects. Airborne particles are formed by complex mixtures of hundreds of compounds, some of which are extracted organic matter (EOM) potentially mutagenic, cytotoxic and carcinogenic (Lewtas, 1993;Villalobos-Pietrini et al, 2006, 2007. For this reason special attention has been applied in assays to evaluate the genotoxicity produced by these pollutants.…”

“…Thermal extraction is used to differentiate between organic carbon and elemental carbon (Johnson et al, 1981) or to characterize the organic chemical composition (Vogt et al, 2007). Solvent extraction (Alves et al, 2000;Tran et al, 2007) is a method by which the organic matter extracted with organic solvents is used to determine the organic mass concentration (Alves et al, 2000;Villalobos-Pietrini et al, 2006), to speciate organic compounds Valle-Hernández et al, 2010) and to perform genotoxic studies , 2007. Gas chromatography-mass spectrometry is the analytical technique most used to characterize their composition.…”

Molecular Markers Associated with the Biological Response to Aromatic Hydrocarbons from Urban Air in Humans

“…The organic chemicals associated with airborne particles can be evaluated through extraction, which generates solvent extractable organic matter (SEOM) that contains hundreds of compounds, among which the PAHs have been the most widely investigated in studies exploring the mutagenic and potentially carcinogenic activity of ambient particulate matter, mainly in Mexico by the Villalobos-Pietrini group (Villalobos-Pietrini et al, 2006). , 2011).…”

Multi-Year PAH Behaviours in Atmospheric Particulates According to Land-Use Type

“…Among the hundreds of PAH compounds found in the environment, 16 are classified as priority pollutants by the USEPA (2003). Additionally, some of these compounds have been shown to be carcinogens and teratogens (Villalobos-Pietrini et al, 2006;Callén et al, 2011).…”