Mutagenicity and genotoxicity of coal fly ash water leachate

Chakraborty, Rajarshi; Mukherjee, Anita

doi:10.1016/j.ecoenv.2008.09.023

Cited by 72 publications

(18 citation statements)

References 34 publications

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“…Regarding the first point, the contaminants content of ashes could be incriminated. Indeed, the toxic and mutagenic effects of high concentrations of FAs on different tests organisms (e.g., Ali et al, 2004;Chakraborty and Mukherjee, 2009;Manerikar et al, 2008;Papadimitriou et al, 2008;Van Maanen et al, 1999;Voelkel et al, 2003) would be linked, according to authors, to organic contaminants or TEs present in such FAs. In our study, both ashes contained TEs (Table 1).…”

Section: Effects Of the Addition Of Fly Ashes To Metal-contaminated Smentioning

confidence: 97%

Effects of field metal-contaminated soils submitted to phytostabilisation and fly ash-aided phytostabilisation on the avoidance behaviour of the earthworm Eisenia fetida

Demuynck

Succiu

Grumiaux

et al. 2014

Ecotoxicology and Environmental Safety

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Section: Effects Of the Addition Of Fly Ashes To Metal-contaminated Smentioning

confidence: 97%

Effects of field metal-contaminated soils submitted to phytostabilisation and fly ash-aided phytostabilisation on the avoidance behaviour of the earthworm Eisenia fetida

Demuynck

Succiu

Grumiaux

et al. 2014

Ecotoxicology and Environmental Safety

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“…Especially, alterations in pulmonary and systemic immune responses, and biochemical and histomorphological changes were found in rats exposed to fly ash (Chauhan et al, 1989;Dogra et al, 1995;Smith et al, 2006). Other studies have shown the possible genotoxic effects of fly ash to human DNA (Kleinjansa et al, 1989;Chakraborty and Mukherjee 2009).…”

Section: Introductionmentioning

confidence: 93%

Subacute inhalation toxicity assessment of fly ash from industrial waste incinerators

Shim¹,

Oh²,

Yang³

et al. 2012

Inhalation Toxicology

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Fly ash from industrial waste incinerators has been a significant concern because of their constituent toxic heavy metals and organic compounds. The objective of this study was to identify the subacute inhalation toxicity of fly ash from industrial waste incinerators, using whole body inhalation exposure chambers. Male and female groups of Sprague-Dawley rats were exposed to fly ash by inhalation of concentrations of 0, 50, 100, 200 mg/m(3), for 6 h/day, 5 days/week for 4 weeks. There was no significant difference in body weight, and relative organ weight to body weight, between the exposure groups and the control group. Hematological examinations revealed a significant increase of monocyte counts in fly ash exposed rats and brown pigment laden macrophage was found in the lungs of rats exposed to high concentration of fly ash. A decrease of blood glucose levels and an increase in glutamate oxaloacetate transaminase activity were observed in fly ash treated rats. There was also a significant increase of lactate dehydrogenase levels in rat blood exposed fly ash. A significant dose-dependent increase of DNA damage was found in lymphocytes, spleen, bronchoalveolar lavage, liver, lung, and thymus of rats exposed to fly ash. In addition, the level of lipid peroxidation was increased in the plasma of rats exposed to a high concentration of fly ash. These results suggest that inhalation of fly ash from industrial waste incinerators can induce histopathologic, hematological, and serum biochemical changes and oxidative damage.

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“…Bekaert et al (1999) showed that the aqueous leachates from a landfill of MSWI ash had a significant genotoxicity on the amphibian erythrocytes with micronucleus assay. Chakraborty and Mukherjee (2009) also reported that fly ash leachate was mutagenic in Salmonella typhimurium and induced DNA damage in vitro in human blood cells and in vivo on Nicotiana plants. The effects of waste leachates on reproductive variables are less commonly evaluated and generally, very limited study is available on potential acute and genotoxicity of hospital waste bottom ash leachate (Racho and Jindal, 2004).…”

Section: Introductionmentioning

confidence: 94%

Hospital waste incinerator bottom ash leachate induced cyto-genotoxicity in Allium cepa and reproductive toxicity in mice

et al. 2011

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The potentials of hospital incinerator bottom ash leachate (HIBAL) to induce cyto-genotoxicity in Allium cepa and reproductive anomalies in the mouse were investigated. The leachate obtained from simulation of the bottom ash was analyzed for some physico-chemical parameters. The A. cepa, mouse sperm morphology and histopathological tests were carried out at concentrations ranging from 1% to 50% of the leachate sample. In A. cepa, HIBAL caused significant (p < 0.05) inhibition of root growth and induction of chromosomal aberrations. In the animal assays, there was 100% mortality at the 50% concentrations. The leachate caused insignificant (p > 0.05) concentration-dependent induction of various types of sperm morphology. There was accumulation of fluid in the seminiferous tubule lumen and necrosis of stem cells in the testes. These effects were believed to be provoked by the somatic and germ cell genotoxins, particularly the heavy metals in the leachate. Our finding is of environmental and public health significance.

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Mutagenicity and genotoxicity of coal fly ash water leachate

Cited by 72 publications

References 34 publications

Effects of field metal-contaminated soils submitted to phytostabilisation and fly ash-aided phytostabilisation on the avoidance behaviour of the earthworm Eisenia fetida

Effects of field metal-contaminated soils submitted to phytostabilisation and fly ash-aided phytostabilisation on the avoidance behaviour of the earthworm Eisenia fetida

Subacute inhalation toxicity assessment of fly ash from industrial waste incinerators

Hospital waste incinerator bottom ash leachate induced cyto-genotoxicity in Allium cepa and reproductive toxicity in mice

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