Mutagenic profile of rubber dust and fume exposure in two rubber tire companies

Vermeulen, Roel; Bos, R.P.; Hartog, Jeroen de; Drooge, H. van; Kromhout, Hans

doi:10.1016/s1383-5718(00)00046-2

Cited by 26 publications

(25 citation statements)

References 18 publications

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“…As concluded in a previous study that assessed different grouping strategies in the rubber manufacturing industry , for retrospective studies like this, a grouping classification based on departments is most likely desirable over a classification based on determinants since they seem to have more historical relevance and are usually more accurately recorded. Nevertheless, this implies that installment of control measures, which has been shown to reduce exposure to inhalable aerosols in the Dutch rubber manufacturing industry by 34-49% (Vermeulen et al, 2000a), will be ignored. Measurement data were collected between 1981 and 1996 only, while the assumption was made that exposure levels were homogeneous before and after this period.…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted, that measurements were not only routinely collected in these departments, but were more specifically collected at different locations (range 1-17) within these departments (Table I). These analyses will focus on inhalable aerosols, total aromatic amines, and CSM (Vermeulen et al, 2000a) measurements. Because of the relatively limited number of personal and worst-case measurements, only routinely collected stationary measurements were used.…”

Section: Datasetmentioning

confidence: 99%

“…Simultaneous with the epidemiological study in the Polish tire production industry, a measurement program was conducted ) covering the period [1981][1982][1983][1984][1985][1986][1987][1988][1989][1990][1991][1992][1993][1994][1995][1996]. In this program a number of different airborne chemicals were monitored, including known mutagenic agents such as inhalable particulate matter (Baranski et al, 1989;Vermeulen et al, 2000aVermeulen et al, , 2001Vermeulen et al, , 2003Monarca et al, 2001) aromatic amines (Golka et al, 2004), trichloroethylene, talc and soot (Straif et al, 1999;Straif et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Elaboration of a quantitative job‐exposure matrix for historical exposure to airborne exposures in the Polish rubber industry

Vocht

Sobala

Pepłońska

et al. 2008

American J Industrial Med

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Section: Discussionmentioning

confidence: 99%

Section: Datasetmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elaboration of a quantitative job‐exposure matrix for historical exposure to airborne exposures in the Polish rubber industry

Vocht

Sobala

Pepłońska

et al. 2008

American J Industrial Med

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“…Examples of such markers are the S. typhimurium mutagenicity assay and the 32 P-postlabeling method for bulky carcinogen-DNA adducts. In several studies in the rubber industry, exposure to mutagenic compounds was established with the S. typhimurium mutagenicity assay either by measuring the mutagenicity of airborne particulates and fumes or by measuring the mutagenicity in the urine of workers [Falck et al, 1980;Sorsa et al, 1982;Baranski et al, 1989;Bos et al, 1989;Fracasso et al, 1999;Vermeulen et al, 2000a]. Although the 32 P-postlabeling method has been used in a large number of studies on occupational exposures to detect carcinogen-DNA adducts [Beach and Gupta, 1992], it has seldom been applied in the rubber industry.…”

Section: Introductionmentioning

confidence: 99%

Urothelial cell DNA adducts in rubber workers†

Vermeulen

Talaska

Schumann

et al. 2002

Environ and Mol Mutagen

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Workers employed in the rubber industry appear to have a significant excess cancer risk in a variety of sites, including cancer of the urinary bladder. In this cross-sectional study, we investigated the occurrence of DNA adducts in exfoliated bladder cells of currently exposed, nonsmoking rubber workers (n = 52) and their relationship with occupational exposure estimates and acetylation phenotype (NAT2). Four DNA adducts were identified, with the proportion of positive samples (e.g., DNA samples with quantifiable levels of a specific DNA adduct) ranging from 3.8 to 79%. The highest proportion of positive samples and the highest relative adduct labeling levels were in workers involved in the production functions "mixing" and "curing," areas with potential for substantial exposure to a wide range of chemical compounds used in rubber manufacturing (P < 0.05 for adducts 2 and/or 3, compared to all other departments). No statistically significant relationships were found between identified DNA adducts and urinary mutagenicity or personal inhalable and dermal exposure estimates. Interestingly, subjects with a fast NAT2 acetylation phenotype tended to have higher levels of DNA adducts. This study suggests that rubber workers engaged in mixing and curing may be exposed to compounds that can form DNA adducts in urothelial cells. Larger studies among rubber workers should be conducted to study in more detail the potential carcinogenicity of exposures encountered in these work areas.

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“…However, we found some interaction of acetylation status on the correlation between urinary mutagenicity Table 3. Association between personal inhalable dust, rubber fumes measured as cyclohexane soluble matter, dermal cyclohexane soluble matter exposure, and urinary levels of 1-hydroxypyrene and mutagenicity Results from earlier studies on mutagenic exposures among rubber manufacturing workers have pointed toward the importance of aromatic amine exposure for genotoxic risk in the rubber manufacturing industry as well (7,31). We found no correlation between bladder and blood cell DNA adduct levels, suggesting that the adducts in each case are potentially formed by different agents and/ or by different metabolic actions.…”

Section: Discussionmentioning

confidence: 99%

Polycyclic Aromatic Hydrocarbon Exposure, Urinary Mutagenicity, and DNA Adducts in Rubber Manufacturing Workers

Peters

Talaska

Jönsson

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Objectives: Several studies have suggested that genotoxic risks might still be present in the contemporary rubber manufacturing industry. Previously, we observed elevated levels of urinary mutagenicity and bladder DNA adducts in rubber workers. Presently, we investigated whether DNA adducts in peripheral blood mononuclear cells (PBMC) and/or urothelial cells may be caused by polycyclic aromatic hydrocarbons or other genotoxic compounds. Methods: Spot urine samples from 116 rubber manufacturing workers were collected on Sunday and during the workweek (post-shift) to determine 1-hydroxypyrene and mutagenicity levels. For 52 nonsmokers, urothelial cell DNA adducts and PBMC DNA adducts were measured additionally. Results: Urinary 1-hydroxypyrene levels were significantly higher in workweek samples compared with Sunday (P = 0.0001). This increase was not uniform across tasks and only reached statistical significance for the curing department (+99%; P = 0.003). Weekday urinary mutagenicity was significantly increased for mixing (+56%) and curing (+21%) workers when compared with that for Sunday. Total urothelial cell DNA adducts were related to urinary 1-hydroxypyrene (P = 0.021) and mutagenicity (P = 0.027). No significant relationship was found between the adduct levels in PBMC and urothelial cells or between the former and urinary 1-hydroxypyrene or mutagenicity. Conclusions: Workers in the compounding, mixing, and curing departments were at highest genotoxic risk among rubber manufacturing workers. Increased levels of urinary 1-hydroxypyrene, mutagenicity, and urothelial cell DNA adducts were found in these workers. Urothelial cell and PBMC DNA adducts were not related, hinting possibly to the presence of specific bladder carcinogens in the rubber manufacturing industry. (Cancer Epidemiol Biomarkers Prev 2008;17(6):1452 -9)

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Mutagenic profile of rubber dust and fume exposure in two rubber tire companies

Cited by 26 publications

References 18 publications

Elaboration of a quantitative job‐exposure matrix for historical exposure to airborne exposures in the Polish rubber industry

Elaboration of a quantitative job‐exposure matrix for historical exposure to airborne exposures in the Polish rubber industry

Urothelial cell DNA adducts in rubber workers†

Polycyclic Aromatic Hydrocarbon Exposure, Urinary Mutagenicity, and DNA Adducts in Rubber Manufacturing Workers

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