Mutagenic compounds in an extract from Rutae Herba (<i>Ruta graveolens</i> L.). I. Mutagenicity is partially caused by furoquinoline alkaloids

Paulini, Hubert; Eilert, U.; Schimmer, Oskar

doi:10.1093/mutage/2.4.271

Cited by 28 publications

(15 citation statements)

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“…Ames assay Mizuta and Kanamori (1985) and Paulini et al (1987) Human cell cultures SCE Schimmer and Leimeister (1989) SCE, sister chromatid exchange; UV-A, long wave ultraviolet; CHO, Chinese hamster ovary. et al, 1982b).…”

Section: Salmonella Typhimuriummentioning

confidence: 99%

Molecular Modes of Action of Defensive Secondary Metabolites

Wink

Schimmer

2010

Functions and Biotechnology of Plant Secondary Metabolites

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Secondary metabolites (SM) have been shaped by evolution for more than 500 million years. As a result, many of them have distinctive biochemical and pharmacological properties. The molecular modes of action of the main groups of SM are reviewed in this chapter. Details are given on interactions of SM with proteins that can induce conformational changes and thus a modification of their bioactivity. The fluidity and permeability of biomembranes constitute another important target, which is influenced by many lipophilic and amphiphilic SM. A number of SM can either alkylate or intercalate DNA, which can cause mutations and in consequence cancer or malformations. Many SM are cytotoxic because they interfere with biomembranes, proteins of the cytoskeleton or DNA; they often induce programmed cell death (apoptosis). A large number of SM, especially alkaloids modulate neuronal signal transduction by interfering with ion channels, ion pumps, neuroreceptors, choline esterase, monoamine oxidase and other enzymes related to signal transduction pathways. A typical feature of SM is their ability to modulate more than one molecular target; thus, additive and even synergistic activities can be expected.

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Section: Salmonella Typhimuriummentioning

confidence: 99%

Molecular Modes of Action of Defensive Secondary Metabolites

Wink

Schimmer

2010

Functions and Biotechnology of Plant Secondary Metabolites

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“…Contact dermatitis and photoxicity characterized by erythema, itching and burning of the skin is a common toxic effect, which is usually associated with all Ruta species (Gijon et al 1995;Heskel et al 1983). Mutagenicity of this plant has been found to be mediated by furoquinoline alkaloids and furocoumarins upon prolonged exposure to sunshine (Chimmer and Kuhne, 1990;Paulini et al 1987).…”

Section: Introductionmentioning

confidence: 99%

Platelet Aggregation Inhibitors from Aerial Parts of Ruta Chalepensis Grown in Jordan

Shehadeh

Afifi

Abuhamdah

2007

Integr Med�Insights

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Abstract:From the aerial parts of Ruta chalepensis L., grown in Jordan, two furanocoumarins (bergapten and chalepensin), one fl avonoid glycoside (rutin) as well as several minor compounds have been isolated. The structural elucidation of these compounds was established based on spectral data (UV, IR, MS, 1 H-NMR and 13 C-NMR). In Jordan, R. chalepensis is recommended for the treatment of rheumatism, mental disorders and menstrual problems. Fresh and dried leaves are used as fl avoring agent in food and beverages. Antiplatelet activities of the crude methanolic and ethylacetate extracts in addition to the three isolated major compounds were measured by the aggrometric method according to Beretz and Casenave. Optical aggregometer connected to dual channel recorder was used for measuring aggregation. Both, ethylacetate and methanol extracts inhibited ADP-induced platelet aggregation (ADP-IA) of human blood. However, only ethylacetate extract was able to induce 50% inhibition of collagen-induced platelet aggregation (Co-IA) platelet rich plasma. Bergapten was more active against ADP-IA compared to chalepensin while the latter was more active against Co-IA compared to bergapten.

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“…Also, the mutagenicity potential of eight plants including Combretum erythrophyllum, Gnidia kraussiana, and Barlerii randii, traditionally used in Zimbabwe has been demonstrated. The mutagenicity of extract from Ruta graveolens in Salmonella tester strain TA98, TA100 has been showed in the presence and absence of S9 mix due to the presence of furoquinoline alkaloids [82].…”

Section: Mutagenicity Of Plant Extracts and Phytocompoundsmentioning

confidence: 99%

Mutagenicity and Antimutagenicity of Medicinal Plants

Musarrat

Aqil

Ahmad

2006

Modern Phytomedicine

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Plants synthesize an array of structurally and functionally diverse bioactive secondary metabolites. These phytocompounds are subject to wide experimental scrutiny for their pharmacological and therapeutic potential. Substantial work has been reported on the screening of medicinal and edible plants for their mutagenicity and/or antimutagenic properties. Most of these natural products are regarded as potential sources of novel therapeutic agents against mutational disorders in humans. For a successful screening program, it is essential to evaluate critically the biological activity of plant extracts through appropriate assay systems. This chapter presents information related to traditionally used medicinal and edible plants endowed with a variety of phytochemicals conferring mutagenicity and antimutagenicity. 13.1

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Mutagenic compounds in an extract from Rutae Herba (Ruta graveolens L.). I. Mutagenicity is partially caused by furoquinoline alkaloids

Cited by 28 publications

References 0 publications

Molecular Modes of Action of Defensive Secondary Metabolites

Molecular Modes of Action of Defensive Secondary Metabolites

Platelet Aggregation Inhibitors from Aerial Parts of Ruta Chalepensis Grown in Jordan

Mutagenicity and Antimutagenicity of Medicinal Plants

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