Mutagenic and cytotoxic activity of an isocoumarin (paepalantine) isolated fromPaepalanthus vellozioides

Varanda, Eliana Aparecida; Raddi, Maria Stella Gonçalves; Dias, Francisca de Luz; Araújo, Maria Cristina P.; Gibran, Solange Cardoso Alvares; Takahashi, Catarina Satie; Vilegas, Wagner

doi:10.1002/(sici)1520-6866(1997)17:2<85::aid-tcm4>3.0.co;2-a

Cited by 41 publications

(30 citation statements)

References 26 publications

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“…However, several studies on the clastogenic action of different compounds have suggested that gaps may indeed be associated with a mutagenic action (Goetz and Dohnalva, 1975;Tavares and Takahashi, 1996;Varanda et al, 1997). Anderson and Richardson (1981) reported that the frequency of gaps was dependent on the dose of the mutagenic agent and that such gaps were as sensitive as other types of aberrations for indicating chromosomal damage.…”

Section: Discussionmentioning

confidence: 99%

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Genotoxic action of the sesquiterpene lactone glaucolide B on mammalian cells in vitro and in vivo

Burim¹,

Canalle²,

Lopes³

et al. 1999

Genet. Mol. Biol.

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Glaucolide B is a sesquiterpene lactone isolated from Vernonia eremophila Mart. (Vernonieae, Asteraceae) and has schistosomicidal, antimicrobial and analgesic activities. This study examined the cytotoxic and clastogenic activities of glaucolide B in human cultured lymphocytes and in bone marrow cells from BALB/c mice. The mitotic index (MI) and chromosomal aberrations were analyzed in both of the above systems, whereas sister chromatid exchanges (SCE) and the proliferation index (PI) were determined only in vitro. In human cultured lymphocytes, glaucolide B concentrations greater than 15 µg/ml of culture medium completely inhibited cell growth. At 4 µg/ml and 8 µg/ml of culture medium, glaucolide B significantly increased the frequency of chromosomal aberrations in lymphocytes and was also cytotoxic at concentrations ≥8 µg/ml; there was no increase in the frequency of SCE. Glaucolide B (160-640 mg/kg) did not significantly increase the frequency of chromosomal aberrations in mouse bone marrow cells nor did it affect cell division. Since glaucolide B showed no clastogenic action on mammalian cells in vivo but was cytotoxic and clastogenic in vitro, caution is needed in its medicinal use.

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Section: Discussionmentioning

confidence: 99%

“…Various toxicological studies have assessed the mutagenic, teratogenic and carcinogenic properties of some of these chemicals (Ames, 1983;Konstantopoulou et al, 1992;Varanda et al, 1997). In many cases, the active compounds have been shown to be sesqui-and diterpenes (Gilbert et al, 1970).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic action of the sesquiterpene lactone glaucolide B on mammalian cells in vitro and in vivo

Burim¹,

Canalle²,

Lopes³

et al. 1999

Genet. Mol. Biol.

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“…Moreover, coumarin (the most effective component of M. officinal) has antioxidant properties that affect the organization and scavenging of ROS. In addition, it can suppress superoxide production in leukocytes via its antioxidant ability, which can influence phagocyte activity (36,37). In this study, we found that M. officinalis has anti-inflammatory properties on acute inflammation in ulcerative colitis models.…”

Section: Discussionmentioning

confidence: 55%

Evaluating the Effect of Melillotus officinalis L. Aqueous Extracts on Healing of Acetic Acid-Induced Ulcerative Colitis in Male Rats

Tanideh¹,

Bahrani²,

Khoshnood-Mansoorkhani³

et al. 2016

Ann Colorectal Res

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“…O interesse em realizar ensaios biológicos com substâncias isoladas de plantas da família Eriocaulaceae surgiu com o isolamento de um metabólito não-usual em plantas, mas freqüente em microorganismos dos gêneros Penicillium e Fusarium (HILL, 1986): a isocumarina paepalantina, isolada dos capítulos de Paepalanthus bromelioides, pertecentes à esta família (VILEGAS et al, 1990). Ensaios biológicos in vitro indicaram forte atividade antibiótica contra Bacillus cereus (7,5 mg/ml), Staphylococcus aureus (7,5 mg/ml), S. epidermidis (15 mg/ml) e Escherichia coli (250 7,5 mg/ml), quando comparada com a azacitidina (0,102 mM), um fármaco utilizado como agente quimioterápico (VARANDA et al, 1997;TAVARES et al, 1999).…”

Section: Introductionunclassified

Atividade antioxidante de xantonas isoladas de espécies de Leiothrix (Eriocaulaceae)

Santos¹,

Piacente²,

Montoro³

et al. 2003

Rev. bras. farmacogn.

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RESUMO:Leiothrix (Eriocaulaceae) é um gênero exclusivo da América do Sul, com 37 espécies restritas ao Brasil. Leiothrix flavescens (Bong.) Ruhland e Leiothrix curvifolia (Bong.) Ruhland, são espécies endêmicas em áreas dos Estados de Minas Gerais e Bahia. Existem na literatura poucos estudos químicos e biológicos realizados com espécies desse gênero. Neste trabalho, foi estudada a atividade antioxidante pelo ensaio TEAC (Trolox Equivalent Antioxidant Capacity) e de autoxidação, utilizando ácido linoléico, de xantonas isoladas dos extratos etanólicos de L. curvifolia e L. flavescens. As substâncias apresentaram moderada atividade antioxidante, quando comparadas com padrões de quercetina e de BHT (2, 6 -ditercbutil -4 -metóxifenil).Unitermos: Ação antioxidante; TEAC; Autoxidação; ácido linoléico; Eriocaulaceae; Leiotrhrix spp.; xantonas.ABSTRACT: Antioxidant effects of xanthones isolated from Leiothrix species (Eriocaulaceae). Leiothrix (Eriocaulaceae) is an exclusively South American genus of which 37 species are restricted to Brazil. Leiothrix flavescens (Bong.) Ruhland and Leiothrix curvifolia (Bong.) Ruhland, are species endemic to areas of Minas Gerais and Bahia States. Chemical and biological investigations of this genus are scarse. The objective of this work was to investigate the antioxidant effect using TEAC and linoleic acid assays of the xanthones isolated from the ethanolic extract of these species. These substances showed a moderate antioxidant activity when compared to quercetin and to BHT.

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Mutagenic and cytotoxic activity of an isocoumarin (paepalantine) isolated fromPaepalanthus vellozioides

Cited by 41 publications

References 26 publications

Genotoxic action of the sesquiterpene lactone glaucolide B on mammalian cells in vitro and in vivo

Genotoxic action of the sesquiterpene lactone glaucolide B on mammalian cells in vitro and in vivo

Evaluating the Effect of Melillotus officinalis L. Aqueous Extracts on Healing of Acetic Acid-Induced Ulcerative Colitis in Male Rats

Atividade antioxidante de xantonas isoladas de espécies de Leiothrix (Eriocaulaceae)

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