Mutagenic Activation of Tris(2,3‐dibromopropyl)phosphate: The Role of Microsomal Oxidative Metabolism

Søderlund, Erik J.; Nelson, Sidney D.; Dybing, Erik

doi:10.1111/j.1600-0773.1979.tb02370.x

Cited by 31 publications

References 20 publications

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A comparison of the ability of frog and rat S‐9 to activate promutagens in the Ames test

et al. 1980

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A mutagenesis assay employing the frog, Rana pipiens, is currently under development [McKinnell et al, 1979]. A question that must be answered is whether the frog is metabolically capable of activating a large number of promutagens. The Ames assay offers a simple means of comparing the metabolism of mutagens by different animal species. The Ames response obtained with frog-liver S-9 was compared to the response with rat-liver S-9, using the following compounds: Benzo(a)pyrene, 7,12-dimethylbenz(a)anthracene, 2-amino-fluorene, azobenzene, Sudan II, dibutylnitrosamine, hydrazine sulfate, hydroxyethylhydrazine, cyclophosphamide, 1,2-dichloroethane, tris(2,3 dibromopropyl)phosphate, diallate, quinoline, quercetin, aflatoxin B 1, emodin, and safrole. Of these compounds, activation by rat S-9 was observed for all except hydrazine sulfate and safrole. All except Sudan II, 1,2-dichloroethane, quinoline, and safrole gave positive Ames responses with frog S-9. In general, the responses with frog S-9 were quantitatively lower than those obtained with Aroclor-induced rat S-9; however, the optimum procedure for frog-liver induction has not been determined. The response to dichloroethane is very sensitive to the amount of activating enzyme present; it might be positive with optimally induced frog S-9. Thus, only two of the 15 compounds positive with rat S-9 were definitely missed when tested with frog S-9. We feel that the frog assay appears to be promising from the standpoint of false-negatives.

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A comparison of the ability of frog and rat S‐9 to activate promutagens in the Ames test

et al. 1980

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Structure‐activity studies on the mutagenicity of tris(2,3‐dibromopropyl) phosphate (tris‐BP) and its metabolites in salmonella

Zeiger¹,

Pagano²,

Nomeir³

1982

Environ. mutagen

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A series of methylated metabolites of the flame retardant tris(2,3-dibromopropyl) phosphate (Tris-BP) were tested for mutagenicity in Salmonella, along with the parent chemical and other structurally related chemicals. The metabolites produced a gradient of mutagenic responses in TA1535 in the same dose range and up to the same magnitude as the Tris-BP response. None of the metabolites tested appeared to be the ultimate mutagen, since they all required S-9 for their mutagenic activity.

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Carcinogenic effects of Bis(2,3‐dibromopropyl)‐phosphate in wistar rats

Naito

Kobayashi

Tobe

et al. 1991

J of Applied Toxicology

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Four groups of 40 Wistar rats of each sex per dose level were fed diets containing 0, 80, 400 or 2000 ppm of the magnesium salt of bis(2,3-dibromopropyl)phosphate (Bis-BP) for 24 months. A high incidence of tumours was induced, in both sexes, in the digestive system. Tumours included papillomas and adenocarcinomas of the tongue, oesophagus and forestomach, adenocarcinomas of the intestine and hepatocellular adenomas (neoplastic nodules) and carcinomas. Pre-terminal mortalities were associated with an increased incidence of forestomach papillomas in both sexes, adenocarcinomas of the small intestine in male rats and increased incidence of hepatocellular carcinomas in females. The data suggest that Bis-BP is a more potent proximate carcinogen than tris-(2,3-dibromopropyl)phosphate (Tris-BP).

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Mutagenic Activation of Tris(2,3‐dibromopropyl)phosphate: The Role of Microsomal Oxidative Metabolism

Cited by 31 publications

References 20 publications

A comparison of the ability of frog and rat S‐9 to activate promutagens in the Ames test

A comparison of the ability of frog and rat S‐9 to activate promutagens in the Ames test

Structure‐activity studies on the mutagenicity of tris(2,3‐dibromopropyl) phosphate (tris‐BP) and its metabolites in salmonella

Carcinogenic effects of Bis(2,3‐dibromopropyl)‐phosphate in wistar rats

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