Mussel-Inspired Chemistry for Robust and Surface-Modifiable Multilayer Films

Abstract

In this article, we report a bioinspired approach to preparing stable, functional multilayer films by the integration of mussel-inspired catechol oxidative chemistry into a layer-by-layer (LbL) assembly. A polyanion of poly(acrylic acid-g-dopamine) (PAA-dopamine) bearing catechol groups, a mussel adhesive protein-mimetic polymer, was synthesized as the building block for LbL assembly with poly(allylamine hydrochloride) (PAH). The oxidization of the incorporated catechol group under mild oxidative condition yields o-quinone, which exhibits high reactivity with amine and catechol, thus endowing the chemical covalence and retaining the assembled morphology of multilayer films. The cross-linked films showed excellent stability even in extremely acidic, basic, and highly concentrated aqueous salt solutions. The efficient chemical cross-linking allows for the production of intact free-standing films without using a sacrificial layer. Moreover, thiol-modified multilayer films with good stability were exploited by a combination of thiols-catechol addition and then oxidative cross-linking. The outstanding stability under harsh conditions and the facile functionalization of the PAA-dopamine/PAH multilayer films make them attractive for barriers, separation, and biomedical devices.

Layer-by-layer Nanoarchitectonics: Invention, Innovation, and Evolution

“…Zhao, Xu, and coworkers proposed construction for robust and surface-modifiable LbL assemblies based on mussel adhesive protein-inspired catechol oxidative chemistry ( Figure 12). 284 Poly(acrylic acidγ-dopamine) (PAAdopamine) bearing catechol groups was used as an anion component for LbL assembly with PAH. Oxidization of the incorporated catechol group resulted in formation of oquinone.…”

Simple Coatings to Render Polystyrene Protein Resistant

“…et al [22,23]. Since then, a variety of dopamine-assisted grafting techniques and DOPA modified antifouling polymers have been tested to more securely attach antifouling polymers to substrate surfaces [23][24][25][26][27][28][29][30][31][32][33][34][35]. The polydopamine layer not only readily adheres to most surfaces, but also provides a surface which allows various secondary reactions to take place and could therefore more easily enable the functionalization of material surfaces [22].…”

Do happy catalyst supports work better? Surface coating of silica and titania supports with (poly)dopamine and their application in hydrotreating

“…This is a clear indication of the presence of polymerized/oligomerized dopamine, which undergoes thermal degradation at temperatures higher than 330°C. Further, solid-state UV analysis of the Pdop/SiO 2 support ( an absorbance band at about 280 nm corresponding to catechol groups of dopamine [19]. In addition, an increase in absorbance in the region of 400-800 nm which is characteristic for the polymerization of dopamine, arising from different functional groups in Pdop was also observed [26].…”

“…Under soft conditions, a polydopamine-coated alumina was obtained [18]. The choice of dopamine monomer is (bio-)inspired from the properties of mussel adhesive proteins, on the basis of the strong interfacial binding property of embedded catechol groups [19]. Dopamine polymerizes under mild basic reactions conditions and invariably coat almost all kinds of materials such as metals, metal oxides, polymers, etc [20].…”