Mussel‐Inspired Approach to Constructing Robust Multilayered Alginate Films for Antibacterial Applications

Kim, Suyeob; Moon, Jung-Mi; Choi, Joon Sig; Cho, Woo Kyung; Kang, Sung Min

doi:10.1002/adfm.201600613

Cited by 72 publications

(65 citation statements)

References 36 publications

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“…The wide range of dopamine grafting is achieved by altering the molar ratios of alginate to dopamine. The UV–visible absorption spectroscopy at 280 nm of the alginate–dopamine polymer revealed a dopamine content of 26%, which is close to the dopamine content in Mfp‐3, and also is within the range of dopamine content reported in other dopamine conjugated alginate polymers …”

Section: Resultssupporting

confidence: 79%

“…The dopamine content in mussel foot proteins (Mfps) varies from 10% to 15% in Mfp‐1, 2% to 4% in Mfp‐2, 25% in Mfp‐3, 5% in Mfp‐4, and 30% in Mfp‐5, whereas Mfp‐3 and Mfp‐5 are the proteins that contact the surface and help mussels adhere to wet surfaces . Some research groups reported that the dopamine contents incorporated into alginate ranged from 10% to 42% . The wide range of dopamine grafting is achieved by altering the molar ratios of alginate to dopamine.…”

Section: Resultsmentioning

confidence: 99%

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Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel‐Like Hydrogels at Tissue Interface

Pandey

Hakamivala

et al. 2017

Adv Healthcare Materials

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Popular bioadhesives, such as fibrin, cyanoacrylate, and albumin-glutaraldehyde based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, their performances are limited by weak adhesion strength and rapid degradation. In this study a mussel-inspired, nanocomposite-based, biodegradable tissue adhesive is developed by blending poly(lactic-co-glycolic acid) (PLGA) or N-hydroxysuccinimide modified PLGA nanoparticles (PLGA-NHS) with mussel-inspired alginate-dopamine polymer (Alg-Dopa). Adhesive strength measurement of the nanocomposites on porcine skin-muscle constructs reveals that the incorporation of nanoparticles in Alg-Dopa significantly enhances the tissue adhesive strength compared to the mussel-inspired adhesive alone. The nanocomposite formed by PLGA-NHS nanoparticles shows higher lap shear strength of 33 ± 3 kPa, compared to that of Alg-Dopa hydrogel alone (14 ± 2 kPa). In addition, these nanocomposites are degradable and cytocompatible in vitro, and elicit in vivo minimal inflammatory responses in a rat model, suggesting clinical potential of these nanocomposites as bioadhesives.

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel‐Like Hydrogels at Tissue Interface

Pandey

Hakamivala

et al. 2017

Adv Healthcare Materials

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“…The UV–vis spectrum of FD‐C showed a characteristic peak at 280 nm, which was absent in the UV–vis spectrum of fucoidan ( Figure 2 ). The results indicate that fucoidan was successfully conjugated with the UV‐absorbing dopamine . The catechol content in FD‐C was quantified by comparing with a calibration curve, which was generated using dopamine solutions (Figure S1, Supporting Information), and it was found to be 12.4 wt%.…”

Section: Resultsmentioning

confidence: 96%

Multipurpose Antifouling Coating of Solid Surfaces with the Marine‐Derived Polymer Fucoidan

Jeong

Thủy

et al. 2018

Macromolecular Bioscience

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The control of biofouling, which is the unwanted adsorption of biomolecules and organisms on solid surfaces, is a prerequisite for wider applicability of the functional materials that are currently being used in biomedical industries. One of the frequently used methods for controlling biofouling is the use of surface coatings with antifouling materials. Herein, fucoidan, which is a marine-derived polysaccharide, is reported as a new type of antifouling material that is safe and broadly applicable. Fucoidan is conjugated with catechols, which are known to act as adhesives for grafting functional molecules onto solid substrates. Fucoidan catechol (FD-C) is subsequently utilized for robust fucoidan coatings of solid substrates, and the FD-C-coated surfaces show excellent antifouling capability for fouling organisms, including platelets and bacteria. The FD-C coating is also confirmed to be nonirritating upon skin contact, demonstrating its potential use in public places for inhibiting contagions.

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“…The former might have been caused by the symmetric and asymmetric stretching vibrations of methyl, methylene, and methine in the alkali lignin, and the latter likely consists of the C─O stretching vibration of alkali lignin. For PSF, a broad overlapped band around 3278 cm −1 can be attributed to catechol ─OH/N─H group stretching as the PSF became broader and blunter in comparison to SF, probably due to hydrogen bonding between the polydopamine and SF . A new peak at 1320 cm −1 appeared in the TSF spectra, which belongs to the C─O of aromatic nucleus stretching vibration in tannic acid …”

Section: Resultsmentioning

confidence: 97%

Mussel‐inspired bio‐based water‐resistant soy adhesives with low‐cost dopamine analogue‐modified silkworm silk Fiber

Pang

Zhao

et al. 2019

J of Applied Polymer Sci

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Mussel‐inspired dopamine chemistry is popular among engineers for surface modification on various substrates due to its high efficiency, handy operation process, and strong reactivity. However, the high cost of dopamine does not allow for mass production. In the present study, low‐cost dopamine analogues (alkali lignin and tannic acid) were used to fabricate high‐reactivity silkworm silk fiber (SF) via a simple dip‐coating approach, and were then applied to a soy‐based adhesive to enhance its performance. The SF tightly combines with soy protein mainly via a Schiff base reaction between polydopamine or dopamine analogue and the amine or thiol groups of soy protein; this forms a multiple crosslinked system and “reinforced concrete”‐like structure, as confirmed by Fourier transform infrared spectroscopy, X‐ray diffraction, thermogravimetry, and scanning electron microscopy analyses. As expected, the toughness of the soy‐based adhesive obviously improved and the highest wet shear strength of the adhesive samples attained 1.50 MPa, which is far greater than relevant interior use requirements. Though dopamine‐coated SF could significantly enhance the wet shear strength of the soy‐based adhesive by 387.1% compared to the pristine SM adhesive, lignin‐coated and tannic acid‐coated SFs are more suitable for practical application due to the lower cost of raw materials. The results of this study may represent an effective and low‐cost approach to mussel‐inspired surface modification chemistry for the mass production of high‐performance soy‐based adhesives. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48785.

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Mussel‐Inspired Approach to Constructing Robust Multilayered Alginate Films for Antibacterial Applications

Cited by 72 publications

References 36 publications

Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel‐Like Hydrogels at Tissue Interface

Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel‐Like Hydrogels at Tissue Interface

Multipurpose Antifouling Coating of Solid Surfaces with the Marine‐Derived Polymer Fucoidan

Mussel‐inspired bio‐based water‐resistant soy adhesives with low‐cost dopamine analogue‐modified silkworm silk Fiber

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