Musical syntactic processing in agrammatic Broca's aphasia

Patel, Aniruddh D.; Iversen, John R.; Wassenaar, Marlies; Hagoort, Peter

doi:10.1080/02687030701803804

Cited by 78 publications

(59 citation statements)

References 23 publications

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“…The cerebellar activation observed during musical priming might reflect increased auditory processing or attention in response to unexpected events, rather than playing a direct role in mediating the expectations themselves. In contrast to cerebellar damage, lesions causing Broca's aphasia were associated with reduced musical priming effects (Patel et al, 2004;Patel, 2005), with frontal brain areas suggested to be more directly involved in the processing of musical relations (Patel, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…However, the functional imaging data on musical priming do not inform us whether the cerebellum is mandatory for musical structure processing, as suggested recently for inferior frontal areas (Patel, 2003). For patients with Broca's aphasia (showing lesions in frontal and temporal lobes), behavioral musical priming effects were reduced: musically unrelated events did not result in increased processing times in comparison to related events on the group level (Patel, Iversen & Hagoort, 2004;Patel, 2005). Our present study investigated whether this would also be the case for patients with cerebellar dysfunction.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 90%

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Cerebellar patients demonstrate preserved implicit knowledge of association strengths in musical sequences

Tillmann

Justus

Bigand

2008

Brain and Cognition

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Recent findings suggest the involvement of the cerebellum in perceptual and cognitive tasks. Our study investigated whether cerebellar patients show musical priming based on implicit knowledge of tonal-harmonic music. Participants performed speeded phoneme identification on sung target chords, which were either related or less-related to prime contexts in terms of the tonal-harmonic system. As groups, both cerebellar patients and age-matched controls showed facilitated processing for related targets, as previously observed for healthy young adults. The outcome suggests that an intact cerebellum is not mandatory for accessing implicit knowledge stored in long-term memory and for its influence on perception. One patient showed facilitated processing for less-related targets (suggesting sensory priming). The findings suggest directions for future research on auditory perception in cerebellar patients to further our understanding of cerebellar functions. Keywordsnonverbal auditory perception/music perception; implicit knowledge; music cognition; cerebellum; cognitive priming; neuropsychology Numerous neuropsychological and neuroimaging findings suggest that the function of the cerebellum is not restricted to movement and motor control, but extends to perceptual and cognitive capacities. A seminal fMRI paper by Gao et al. (1996) reported that the dentate nuclei of the cerebellum were more active during manual tasks that emphasized sensory discrimination, rather than during movement per se. Neuroimaging studies have shown increased activation of the cerebellum during auditory tasks (Petacchi et al., 2005), such as frequency, intensity and duration discrimination (Belin et al., 2002), the processing of complex nonspeech sounds over pure tones (Vouloumanos et al., 2001), as well as for auditory attention (Janata, Tillmann, & Bharucha, 2002) and the perception of musical structures (Parsons, 2001;Tillmann, Janata, & Bharucha, 2003). Work in auditory perception is just one piece of a larger emerging picture that suggests potential cerebellar contributions to higher cognitive functions involving memory and language (see Fiez, 1996;Justus & Ivry, 2001 for reviews). Although the cerebellum seems to be implicated in perceptual and cognitive functions, no Correspondence concerning this article should be addressed to: Barbara Tillmann, Université Claude Bernard -Lyon I, CNRS UMR 5020, Neurosciences et Systèmes Sensoriels, 50 Av. Tony Garnier, F-69366 Lyon Cedex 07, France, Tel : +33 (0) 4 37 28 74 93, Fax : +33 (0) 4 37 28 76 01, barbara.tillmann@olfac.univ-lyon1.fr. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers...

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Section: Discussionmentioning

confidence: 99%

Section: Nih-pa Author Manuscriptmentioning

confidence: 90%

Cerebellar patients demonstrate preserved implicit knowledge of association strengths in musical sequences

Tillmann

Justus

Bigand

2008

Brain and Cognition

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“…Indeed, as predicted by the structured sequence processing account, the LIFG is activated in musical structured sequence processing [28][29][30]. Moreover, musicians show increased grey matter density in the LIFG compared with non-musicians [27], and Broca's aphasics are impaired in processing musical sequences [31]. Surrounding areas have also been activated in both musical processing and AGL, in particular the frontal operculum [6,9,53,54] and the anterior insula [6,9,53,54].…”

Section: Neuroimaging Of the Left Inferior Frontal Gyrus In Artificiamentioning

confidence: 90%

“…The central empirical observation in favour of the structured sequence processing perspective on LIFG function is the overlapping activation of the LIFG during language processing, divided into phonological, syntactic and semantic aspects [22][23][24][25][26], in music [27][28][29][30][31] and action processing [32,33]. We will review this literature further on, but let us first note that these results make sense if there are domain general structured sequence processing mechanisms in the LIFG, used across the domains of language, music and action.…”

Section: The Structured Sequence Processing Perspectivementioning

confidence: 99%

A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus

Uddén

Bahlmann

2012

Phil. Trans. R. Soc. B

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In this paper, we present two novel perspectives on the function of the left inferior frontal gyrus (LIFG). First, a structured sequence processing perspective facilitates the search for functional segregation within the LIFG and provides a way to express common aspects across cognitive domains including language, music and action. Converging evidence from functional magnetic resonance imaging and transcranial magnetic stimulation studies suggests that the LIFG is engaged in sequential processing in artificial grammar learning, independently of particular stimulus features of the elements (whether letters, syllables or shapes are used to build up sequences). The LIFG has been repeatedly linked to processing of artificial grammars across all different grammars tested, whether they include non-adjacent dependencies or mere adjacent dependencies. Second, we apply the sequence processing perspective to understand how the functional segregation of semantics, syntax and phonology in the LIFG can be integrated in the general organization of the lateral prefrontal cortex (PFC). Recently, it was proposed that the functional organization of the lateral PFC follows a rostro-caudal gradient, such that more abstract processing in cognitive control is subserved by more rostral regions of the lateral PFC. We explore the literature from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC. If the lateral PFC follows a rostro-caudal abstraction gradient, then this predicts that the LIFG follows the same principles, but this prediction has not yet been tested or explored in the LIFG literature. Integration might provide further insights into the functional architecture of the LIFG and the lateral PFC.

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“…Furthermore, several recent studies have shown that the left inferior frontal region has a broader role in cognition than just language (Hagoort, 2005;Marcus, Vouloumanos, & Sag, 2003), including musical syntax (e.g., Koelsch et al, 2002;Maess, Koelsch, Gunter, & Friederici, 2001) and visuo-spatial sequence processing (Bahlmann, Schubotz, Mueller, Koester, & Friederici, in press). Thus, next to evidence from a study on aphasic patients (Patel, Iversen, Wassenaar, & Hagoort, 2008), a growing body of evidence from functional neuroimaging suggests an overlap in the processing of structural relations in language and music (for a review see Patel, 2003). It is also of interest to note that there seems to be a considerable overlap between regions implicated in the perception/production of music and the perception/production of abstract sequences, including the left inferior frontal region (Janata & Grafton, 2003;Tillmann et al, 2006).…”

Section: Dynamic Functional Modularity and The Role Of The Left Infermentioning

confidence: 99%

What artificial grammar learning reveals about the neurobiology of syntax

2012

Self Cite

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a b s t r a c tIn this paper we examine the neurobiological correlates of syntax, the processing of structured sequences, by comparing FMRI results on artificial and natural language syntax. We discuss these and similar findings in the context of formal language and computability theory. We used a simple right-linear unification grammar in an implicit artificial grammar learning paradigm in 32 healthy Dutch university students (natural language FMRI data were already acquired for these participants). We predicted that artificial syntax processing would engage the left inferior frontal region (BA 44/45) and that this activation would overlap with syntax-related variability observed in the natural language experiment. The main findings of this study show that the left inferior frontal region centered on BA 44/45 is active during artificial syntax processing of well-formed (grammatical) sequence independent of local subsequence familiarity. The same region is engaged to a greater extent when a syntactic violation is present and structural unification becomes difficult or impossible. The effects related to artificial syntax in the left inferior frontal region (BA 44/45) were essentially identical when we masked these with activity related to natural syntax in the same subjects. Finally, the medial temporal lobe was deactivated during this operation, consistent with the view that implicit processing does not rely on declarative memory mechanisms that engage the medial temporal lobe. In the context of recent FMRI findings, we raise the question whether Broca's region (or subregions) is specifically related to syntactic movement operations or the processing of hierarchically nested non-adjacent dependencies in the discussion section. We conclude that this is not the case. Instead, we argue that the left inferior frontal region is a generic on-line sequence processor that unifies information from various sources in an incremental and recursive manner, independent of whether there are any processing requirements related to syntactic movement or hierarchically nested structures. In addition, we argue that the Chomsky hierarchy is not directly relevant for neurobiological systems.

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Musical syntactic processing in agrammatic Broca's aphasia

Cited by 78 publications

References 23 publications

Cerebellar patients demonstrate preserved implicit knowledge of association strengths in musical sequences

Cerebellar patients demonstrate preserved implicit knowledge of association strengths in musical sequences

A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus

What artificial grammar learning reveals about the neurobiology of syntax

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