Musculoskeletal Disorders and Menopause

Khadilkar, Suvarna

doi:10.1007/s13224-019-01213-7

Cited by 49 publications

(42 citation statements)

References 25 publications

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“…It is possible that differential EV protein cargo in female synovial fluid may be due to a decline in estrogen levels. It is well known that declining estrogen levels are inversely related to increased incidence and severity of OA in females [ 49 , 50 , 51 , 52 ]. We previously demonstrated that estrogen inhibitor treatment alters miRNA cargo in female synovial fibroblast cells [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

Kolhe

Owens

Sharma

et al. 2020

Life

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Women are at a significantly higher risk of developing osteoarthritis (OA) compared to males. The pathogenesis of osteoarthritis (OA) in women is poorly understood. Extracellular vesicles (EVs) have been shown to play an essential role in numerous signaling processes during the pathogenesis of age-related diseases via paracrine signaling. Molecular profiling of the synovial fluid-derived EVs cargo in women may help in the discovery of novel biomarkers and therapeutics for the treatment of OA in women. Previously, we reported that synovial fluid-derived EV miRNA cargo differs in a sex-specific manner. This study aims to characterize synovial fluid-derived EV protein cargo in OA patients. Our data showed sex-specific EVs protein content in OA. We found haptoglobin, orosomucoid, and ceruloplasmin significantly up-regulated, whereas apolipoprotein down-regulated in female OA EVs. In males, we discovered β-2-glycoprotein, and complement component 5 proteins significantly up-regulated and Spt-Ada-Gcn5 acetyltransferase (SAGA)-associated factor 29 down-regulated in male OA EVs. Database for Annotation, Visualization, and Integrated Discovery (DAVID) and QuickGO analysis revealed OA-specific protein involvement in several biological, molecular, and cellular pathways, specifically in inflammatory processes. In conclusion, synovial fluid EV protein content is altered in a sex-specific manner with OA, explaining the increased prevalence and severity of OA in women.

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Section: Discussionmentioning

confidence: 99%

Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

Kolhe

Owens

Sharma

et al. 2020

Life

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“…Nevertheless, our results are opposite to those found by Bravo-José et al [14], who found a higher prevalence among female people (81.4%). It is known that female sex factors, such as menopause, increase risk of osteoporosis, as well as sarcopenia, besides a lower production of estrogen hormones [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Sensibilidade e especificidade do SARC-F na classificação de sarcopenia em idosos: resultados preliminares

Reis

Vianna

Colugnati

et al. 2021

Rev Bras Fisiol Exerc

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Introduction: In addition to being prevalent in the elderly population, sarcopenia has become a precursor to functional decline in this population. Alternative means for screening is necessary. Objectives: The aim of this study was to evaluate the sensitivity and specificity of the SARC-F sarcopenia screening instrument. Methods: The sample consisted of 153 elderly of both sexes. Screening of sarcopenia was evaluated by the SARC-F questionnaire. Strength, function and muscle mass were evaluated through the protocol adapted from the European Working Group on Sarcopenia in Older People (EWGSOP). The sensitivity and specificity of the questionnaire were evaluated using the ROC curve. Results: 13.72% of the elderly evaluated were classified as sarcopenic. The parameters most related to sarcopenia were older and lack of physical exercise. Sex was not a parameter that had a relationship in classification. Sensitivity was 60.0% and specificity of 80.92% with an area on the curve of 0.70. Conclusion: Our data supports the use of SARC-F as a screening tool that can be used in community and hospital environments as a quick screening tool.Keywords: muscle strength, aged, sarcopenia.

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“…42 And the bioavailable testosterone which may contribute to the increase in muscle mass is decreased in elderly women. 43,44 Therefore, the decline of estrogen levels among elderly women and lower hemoglobin may have a synergistic effect on the health of muscle function and contributes to pathogenesis of frailty. However this possibility need more epidemiologic support.…”

Section: Discussionmentioning

confidence: 99%

Effect Modification by Sex of the Hemoglobin Concentration on Frailty Risk in Hospitalized Older Patients

Chen

Han

2021

CIA

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Background: Hemoglobin concentration differs by sex, possibly affecting any association between hemoglobin and frailty. This study aimed to evaluate the potential interaction effect of hemoglobin and sex on frailty in Chinese older inpatients. Methods: A cross-sectional study was conducted between February 2015 and November 2017 in a tertiary hospital. Frailty was defined by the Fried phenotype. Hemoglobin concentration was measured with a standard procedure. Covariates included demographics, clinical characteristics, and serum biomarkers. Logistic regression was applied to examine the association between hemoglobin concentration and frailty. The relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (SI) were used to evaluate the additive interaction. Results: A total of 619 older inpatients [mean age 69.26±7.44 years; 334 men, 285 women] were included. The mean hemoglobin concentration was significantly lower in the elderly who were frail (11.9 g/L in frail versus 13.1g/L in non-frail; p<0.001). In the multivariable regression models, lower hemoglobin in patients was significantly associated with frailty (adjusted odds ratio (OR) = 2.51, 95% CI:1.37, 4.60). The stratified analyses indicated that lower hemoglobin was associated with frailty among older inpatients with different characteristics. Female inpatients with lower hemoglobin had the highest risk of frailty (adjusted OR=6.43, 95%: 2.38, 17.3); there were interactions between hemoglobin and sex on the development of frailty (RERI=4.30, 95% CI=−1.41, 10.01; AP=0.67, 95% CI=0.37, 0.97; SI=4.80, 95% CI=1.22, 18.84). Conclusions and Implications: Our study provided evidence that sex and lower hemoglobin have an interaction effect on frailty; it is suggested that clinicians may consider sexspecific strategies for the elderly to conform the concept of precision medicine.

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Musculoskeletal Disorders and Menopause

Cited by 49 publications

References 25 publications

Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

Sensibilidade e especificidade do SARC-F na classificação de sarcopenia em idosos: resultados preliminares

Effect Modification by Sex of the Hemoglobin Concentration on Frailty Risk in Hospitalized Older Patients

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