Muscular system in maintaining health and preventing chronic non-infectious diseases

Background. Maladaptive changes on the part of various organs and systems, in particular on the part of the hemostasis system, are manifested in extreme forms of physical inactivity, one of which is immobilization stress. If the organism is also subjected to psycho-emotional effects at the same time, then the combined effect of stressors is accompanied by an increase in maladaptive disorders. Aim. To establish the influence of emotional-immobilization stress on the hemostasis system, as well as the possibility of correcting changes by taking a course of eleutherococcus. Material and methods. The experiment was conducted on male rats, which were divided into four groups: the first group (n=14) control, the second group (n=14) animals treated with eleutherococcus for 30 days, the third group (n=14) rats, subjected to a single 3-hour water-immersion dipping, the fourth group (n=14) animals that took eleutherococcus for 30 days before the water-immersion dipping. The state of the hemostasis system was assessed in all experimental groups. Statistical processing of the results was performed using the Statistica 10.0 package (Statsoft, USA). Significance of differences was assessed using the nonparametric MannWhitney test and Student's t-test. Results. A single immobilization effect was accompanied by hypercoagulable changes, which characterized by shortening of the silicone (p=0.001) and kaolin (p=0.002) time. Completion of the 30-day adaptogen intake followed by emotional immobilization stress was accompanied by an increase in silicone (p=0.001), kaolin (p=0.021), prothrombin (p=0.021) and thrombin (p=0.006) time, which indicated hypocoagulation changes. Conclusion. The immobilization effect is characterized by hypercoagulability against the background of a decrease in the anticoagulant and fibrinolytic activity of the blood plasma; the course intake of eleutherococcus prior to immobilization is accompanied by hypocoagulant changes and an increase in the anticoagulant activity of the blood plasma.

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The role of plant adaptogen in the correction of parameters of the hemostasis system during emotional-immobilization stress in the experiment

Obraztsova

Bondarchuk

Шахматов

et al. 2023

Kazan Med J

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Prevalence of main risk factors and cytokine profile in patients with acute coronary syndrome and different serum myostatin levels

Akhmadzyanova,

Khovaeva,

Sosnin

et al. 2024

Perm Medical Journal

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Objective. To study the prevalence of the main risk factors and the value of proinflammatory cytokines in patients with acute coronary syndrome (ACS) depending on the determined level of serum myostatin. Materials and methods. 120 patients with ST elevation ACS (STE-ACS) and non-ST-segment elevation ACS (NSTE-ACS), hospitalized in the cardiology department of the regional vascular center were examined. In 86 patients, the level of serum myostatin and proinflammatory cytokines was determined on the 5th day of the development of acute coronary syndrome. Results. Patients were divided into two subgroups depending on the level of serum myostatin which was determined: group 1 – with a lower level of myostatin, group 2 – with a higher level of myostatin. Group 1 (serum myostatin level from 0.038 to 0.084 ng/ml) consisted of 23 patients (16 males). Group 2 (serum myostatin level from 0.137 to 0.630 ng/ml) contained 21 patients (14 males). The main risk factors for cardiovascular diseases such as family history of early development of cardiovascular diseases, smoking, dyslipidemia, obesity, arterial hypertension and type 2 diabetes mellitus were assessed. The levels of pro-inflammatory cytokines were determined. Tumor necrosis factor alpha (TNF-alpha) and interleukin 18 (IL-18) levels were significantly higher in patients with higher myostatin levels. Correlation analysis revealed a relationship between serum myostatin concentration and TNF-alpha level (r = 0.34; p = 0.0016). Conclusions. No differences in the prevalence of risk factors in patients with ACS and different myostatin levels, except for smoking were revealed in the study, the frequency of smoking was higher in the group with higher myostatin levels. Greater activity of pro-inflammatory cytokines TNF-alpha and IL-18 was revealed in patients with higher levels of myostatin, as well as a significant correlation between the level of myostatin and TNF-alpha.

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Muscular system in maintaining health and preventing chronic non-infectious diseases

Cited by 2 publications

References 21 publications

The role of plant adaptogen in the correction of parameters of the hemostasis system during emotional-immobilization stress in the experiment

The role of plant adaptogen in the correction of parameters of the hemostasis system during emotional-immobilization stress in the experiment

Prevalence of main risk factors and cytokine profile in patients with acute coronary syndrome and different serum myostatin levels

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Muscular system in maintaining health and preventing chronic non-infectious diseases

Cited by 2 publications

References 21 publications

The role of plant adaptogen in the correction of parameters of the hemostasis system during ­emotional-immobilization stress in the experiment

The role of plant adaptogen in the correction of parameters of the hemostasis system during ­emotional-immobilization stress in the experiment

Prevalence of main risk factors and cytokine profile in patients with acute coronary syndrome and different serum myostatin levels

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The role of plant adaptogen in the correction of parameters of the hemostasis system during emotional-immobilization stress in the experiment

The role of plant adaptogen in the correction of parameters of the hemostasis system during emotional-immobilization stress in the experiment