Muscle Wasting Induced by HTLV-1 Tax-1 Protein

Ozden, Simona; Mouly, Vincent; Prévost, Marie‐Christine; Gessain, Antoine; Butler‐Browne, Gillian; Ceccaldi, Pierre‐Emmanuel

doi:10.1016/s0002-9440(10)61245-x

Cited by 20 publications

(12 citation statements)

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“…No immunoreactive cells were detected (data not shown). In addition, no signal could be seen in biopsies samples from three different non-infected control individuals (Fig 2G, and data not shown) and from a HTLV-1-infected patient with myositic syndrome[11] using anti-CHIK virus HMAF as primary antibody (Fig. 2H).…”

Section: Resultsmentioning

confidence: 95%

“…G: West Nile virus (IS-98-ST1 srtrain) used as the primary antibody (muscle section from patient#1); no staining was observed; similar results were obtained with sera against yellow fever virus, or dengue type-1 virus (data not shown). G,H: sections from a non-infected patient (G) or from a HTLV-1-infected patient with myositic syndrome[11] (H) used as controls; no significant immunoreactivity detected. I: double labeling by immunofluorescence of CHIK virus antigens (green staining; HMAFs anti CHIK virus #1) and laminin (red staining; rabbit anti-laminin polyclonal antibody).…”

Section: Resultsmentioning

confidence: 99%

“…Sections of muscles from a non-infected patient and from a HTLV-1-infected patient with a myositic syndrome, were used as negative controls, as reported in a recent paper [11].…”

Section: Methodsmentioning

confidence: 99%

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Human Muscle Satellite Cells as Targets of Chikungunya Virus Infection

et al. 2007

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BackgroundChikungunya (CHIK) virus is a mosquito-transmitted alphavirus that causes in humans an acute infection characterised by fever, polyarthralgia, head-ache, and myalgia. Since 2005, the emergence of CHIK virus was associated with an unprecedented magnitude outbreak of CHIK disease in the Indian Ocean. Clinically, this outbreak was characterized by invalidating poly-arthralgia, with myalgia being reported in 97.7% of cases. Since the cellular targets of CHIK virus in humans are unknown, we studied the pathogenic events and targets of CHIK infection in skeletal muscle.Methodology/Principal FindingsImmunohistology on muscle biopsies from two CHIK virus-infected patients with myositic syndrome showed that viral antigens were found exclusively inside skeletal muscle progenitor cells (designed as satelllite cells), and not in muscle fibers. To evaluate the ability of CHIK virus to replicate in human satellite cells, we assessed virus infection on primary human muscle cells; viral growth was observed in CHIK virus-infected satellite cells with a cytopathic effect, whereas myotubes were essentially refractory to infection.Conclusions/SignificanceThis report provides new insights into CHIK virus pathogenesis, since it is the first to identify a cellular target of CHIK virus in humans and to report a selective infection of muscle satellite cells by a viral agent in humans.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

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Human Muscle Satellite Cells as Targets of Chikungunya Virus Infection

et al. 2007

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“…HTLV-1 has been found to be myotoxic in vitro [175]. Polymyositis, dermatomyositis and sporadic inclusion body myositis are uncommon but have been reported in HTLV-1 infected adults and children [53,176,177].…”

Section: Htlv-1 Associated Inflammatory Myositismentioning

confidence: 99%

Inflammatory manifestations of HTLV-1 and their therapeutic options

Martin

Taylor

Jacobson

2014

Expert Review of Clinical Immunology

103

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Human T lymphotropic virus type 1 (HTLV-1) is one of the most intriguing retroviruses infecting humans. Most commonly, infection remains undetected, since it does not cause obvious harm, yet in 4-9% of patients, this infection can be devastating, causing adult T-cell leukemia/lymphoma and/or HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). This review concentrates on all inflammatory aspects of HTLV-1 infection: HAM/TSP, HTLV-1 associated uveitis, HTLV-1 associated conjunctivitis, sicca syndrome and interstitial keratitis, HTLV-1 associated Sjö gren's syndrome, Hashimoto's thyroiditis and Graves' disease, HTLV-1 associated pulmonary disease, infective dermatitis associated with HTLV-1, HTLV-1 associated inflammatory myositis and HTLV-1 associated arthritis. With the exception of HAM/TSP treatment, studies of these conditions are sparse and even for HAM/TSP, the level of evidence is limited. While control or elimination of infection remains a goal, most therapy beyond symptomatic management is directed at the immune response to HTLV-1.

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“…HTLV-1 is the causative agent of adult T-cell leukemia/lymphoma (ATL) (46) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) (15). It has also been associated with a number of inflammatory diseases, including pediatric infectious dermatitis (29,32), uveitis (37), and some cases of myositis (38,44). HTLV-2 may be responsible for rare neurological syndromes that are clinically related to TSP/HAM (22,40), but no tumors have been linked definitively to such infection (12,23).…”

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New Insights into Prevalence, Genetic Diversity, and Proviral Load of Human T-Cell Leukemia Virus Types 1 and 2 in Pregnant Women in Gabon in Equatorial Central Africa

et al. 2008

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Human T-cell leukemia virus type 1 (HTLV-1) is highly endemic in areas of central Africa; mother-to-child transmission and sexual transmission are considered to be the predominant routes. To determine the prevalence and subtypes of HTLV-1/2 in pregnant women in Gabon, we conducted an epidemiological survey in the five main cities of the country. In 907 samples, the HTLV-1 seroprevalence was 2.1%, which is lower than that previously reported. Only one case of HTLV-2 infection was found. The HTLV-1 seroprevalence increased with age and differed between regions (P < 0.05), with the highest prevalence (5%) in the southeastern region. A wide range of HTLV-1 proviral loads was observed among the infected women. The level of the proviral load was correlated with a high HTLV-1 antibody titer (P < 0.02). Sequencing of HTLV-1 env and long terminal repeat fragments showed that all but one strain belonged to the central African subtype B; the outlier was of cosmopolitan subtype A. The new strains of subtype B exhibited wide genetic diversity, but there was no evidence of clustering of specific genomes within geographical regions of the country. Some strains were closely related to simian T-cell leukemia virus type 1 strains of great apes, suggesting that in these areas some HTLV-1 strains could arise from relatively recent interspecies transmission. The sole HTLV-2 strain belonged to subtype B. In this study we showed that the prevalence of HTLV-1 in the southeast is one of the highest in the world for pregnant women.

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Muscle Wasting Induced by HTLV-1 Tax-1 Protein

Cited by 20 publications

References 57 publications

Human Muscle Satellite Cells as Targets of Chikungunya Virus Infection

Human Muscle Satellite Cells as Targets of Chikungunya Virus Infection

Inflammatory manifestations of HTLV-1 and their therapeutic options

New Insights into Prevalence, Genetic Diversity, and Proviral Load of Human T-Cell Leukemia Virus Types 1 and 2 in Pregnant Women in Gabon in Equatorial Central Africa

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