Muscle velocity recovery cycles: Effects of repetitive stimulation on two muscles

Boërio, Delphine; Z'Graggen, Werner Josef; Tan, S. Veronica; Guetg, Andri; Ackermann, Karin; Bostock, Hugh

doi:10.1002/mus.23267

Cited by 27 publications

(38 citation statements)

References 26 publications

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“…In contrast to the high sensitivity of MRRP to temperature, ESN and also the ISI for peak supernormality did not change significantly in the temperature range of 30°–34°C. In several earlier studies, ESN has been shown to be a highly valuable parameter to detect changes in muscle membrane potential 2–7. If adequate temperature control is not possible, ESN should be considered the most suitable parameter to detect changes of muscle membrane properties.…”

Section: Discussionmentioning

confidence: 99%

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Temperature dependency of human muscle velocity recovery cycles

et al. 2012

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Section: Discussionmentioning

confidence: 99%

“…The depolarizing afterpotential is associated with a period of increased conduction velocity, that is, supernormality. Recent studies have demonstrated that this method is very sensitive to changes in membrane potential 2–7. However, the effects of changes in muscle temperature have not been investigated previously.…”

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confidence: 99%

Temperature dependency of human muscle velocity recovery cycles

et al. 2012

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“…The activity‐dependent velocity changes were compared with recordings from 30 normal controls (NC): 19 women and 11 men, aged 41.9 ± 14.7 years (range 21–67 years), including 20 from a previous study …”

Section: Methodsmentioning

confidence: 99%

“…The recording technique was similar to that developed for the brachioradialis muscle, but adapted to tibialis anterior (TA) . Recordings were performed on the distal third of TA, with a monopolar stimulating needle inserted perpendicularly within 1 cm of the palpated distal extent of the muscle.…”

Section: Methodsmentioning

confidence: 99%

Chloride channels in myotonia congenita assessed by velocity recovery cycles

et al. 2014

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Introduction: Myotonia congenita (MC) is caused by congenital defects in the muscle chloride channel CLC-1. This study used muscle velocity recovery cycles (MVRCs) to investigate how membrane function is affected. Methods: MVRCs and responses to repetitive stimulation were compared between 18 patients with genetically confirmed MC (13 recessive, 7 dominant) and 30 age-matched, normal controls. Results: MC patients exhibited increased early supernormality, but this was prevented by treatment with sodium channel blockers. After multiple conditioning stimuli, late supernormality was enhanced in all MC patients, indicating delayed repolarization. These abnormalities were similar between the MC subtypes, but recessive patients showed a greater drop in amplitude during repetitive stimulation. Conclusions: MVRCs indicate that chloride conductance only becomes important when muscle fibers are depolarized. The differential responses to repetitive stimulation suggest that, in dominant MC, the affected chloride channels are activated by strong depolarization, consistent with a positive shift of the CLC-1 activation curve.

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“…The technique is based on the principle that an elicited action potential induces a depolarizing afterpotential, which declines in 2 phases over approximately 1 s (early and late supernormality) to its resting membrane potential . If a second action potential is evoked during this period, its propagation velocity will be increased, depending on the inter‐stimulus interval …”

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confidence: 99%