2017
DOI: 10.1590/1980-5918.030.002.ao14
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Introduction: Crohn’s disease (CD) is an inflammatory bowel disease, marked by exacerbations and remissions periods. Peripheral manifestations in CD may be present with the syndrome of skeletal muscle dysfunction (SMD), which is characterized by loss of muscle strength, fatigue complain, limited exercise capacity and impaired quality of life of these patients. Objective: Evaluate muscle strength, physical capacity and quality of life of patients with CD and compare them with healthy controls. Methods: 18 pat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
8
0

Year Published

2018
2018
2021
2021

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

citations
Cited by 5 publications
(28 citation statements)
references
References 33 publications
(28 reference statements)
0
8
0
Order By: Relevance
“…Among the major determinates of oxygen utilization, mitochondrial oxidative phosphorylation plays an essential role in supplying adequate energy for cellular processes both at rest and during exercise. Indeed, impairments in muscle oxidative capacity can limit functional capacity and quality of life 14,15,16 . Various measures are commonly used to provide an index of muscle oxidative capacity, including invasive muscle biopsies and expensive and time-consuming magnetic resonance spectroscopy (MRS) techniques.…”
Section: Introductionmentioning
confidence: 99%
“…A recent article from our group showed muscle functional impairment and poorer quality of life in patients with CD compared to healthy controls (28) . However, the control group consisted of healthy volunteers and the CD group was formed by patients in the active phase of the disease, different from the present study.…”
Section: Discussionmentioning
confidence: 85%
“…21 Moreover, the hormonic anabolic process, such as hepatocyte growth factor and myokines as IL-5, and IL-6, 18 IL-10, 1 fibroblast growth, and leukemia inhibitory factor, promotes the anabolism and anti-inflammation. 17 Wiroth et al 22 and Cabalzar et al 23 highlighted that CD patients in both remission and active phase showed decrements on the strength performance such as limb strength, limb endurance, and sit-up test concerning healthy participants. 22 Also, showed a lower respiratory and peripheral muscle strength.…”
Section: Resultsmentioning
confidence: 99%
“…In many patients with IBD and particularly with CD, the body composition, reflected by as proportions of bone, fat, and lean body mass may be abnormal. Sarcopenia, defined as depletion of muscle mass and impaired muscle function [65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82], is an important feature in this disease [70][71][72]81]. Depletion of lean body mass and loss of muscle strength associated with lower QoL and higher mortality and morbidity commonly occurs as part of the aging process [65,77].…”
Section: Skeletal Mass Depletion In Ibdmentioning
confidence: 99%
“…Recently, a number of reports about the increasing rates of sarcopenia in patients with IBD, especially in patients with CD were observed [69,78]. Such sarcopenia in IBD patients is associated with an increased risk of surgery, poor surgical outcomes, lower QoL, osteopenia, and easy fatigue [66,67,[70][71][72][73][74]77,80]. The unchanged or elevated BMI was observed in IBD patients who suffered with loss of muscle mass, followed by muscle impaired function [68,[70][71][72].…”
Section: Skeletal Mass Depletion In Ibdmentioning
confidence: 99%