Muscle enzymes in the diagnosis of ovine weaner nutritional myopathy

Jm, Fry; Jg, Allen; Speijers, EJ; Wd, Roberts

doi:10.1111/j.1751-0813.1994.tb03369.x

Cited by 16 publications

(8 citation statements)

References 13 publications

(3 reference statements)

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“…In lambs with white muscle disease, levels of selenium in blood decreased 3,5 activity of erythrocyte GSH-Px reduced and activity of CK increased in comparison to healthy lambs 7 . Some researchers have reported that early diagnosis is important in WMD as appropriate treatment and prophylactic protocols are applied 1,6,7 . As values of serum enzyme including ALT, AST, ALP, LDH and CK are higher in lambs with NMD than healthy lambs 1,7 .…”

Section: Discussionmentioning

confidence: 99%

“…Nutritional Myodegeneration disease, an subclinic or KOZAT, ALTUĞ YÜKSEK, ÖZKAN clinic form of metabolic disorder of lambs 6 , is characterized clinically by locomotor disturbance and circulatory failure, and pathologically by degeneration and necrosis of skeletal and cardiac muscle 24,25 . In lambs with white muscle disease, levels of selenium in blood decreased 3,5 activity of erythrocyte GSH-Px reduced and activity of CK increased in comparison to healthy lambs 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Prior to the fi rst clinical signs of NMD in lambs, there is a certain increase in blood CK, AST, LDH, and ALP concentrations, indicatives of muscle degeneration 1,[6][7][8] . On the other hand, activity of GSH-Px enzyme is slightly decreased 9 .…”

Section: Introductionmentioning

confidence: 99%

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Subklinik Beyaz Kas Hastalıklı Kuzularda Homosistein, Troponin I ve Nitrik Oksit Düzeylerinin Değerlendirilmesi

Kozat¹,

Altuğ²,

Yüksek³

et al. 2009

Kafkas Univ Vet Fak Derg

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SummaryWhite muscle disease (WMD) or Nutritional myodegeneration disease (NMD) is a degenerative disease of the cardiac and skeletal muscles. The level of serum activity of Plasma homocysteine (Hcy), cardiac troponin I (cTn I), Nitric oxide (NO) were investigated in lambs with subclinical NMD in this study. Ten healthy lambs and twenty lambs with subclinical NMD were used in this study. The blood samples were firstly taken at the onset of the disease and then 3 and 10 days after treatment in NMD, and taken once control group. The values of serum activity of creatin kinase (CK), aspartate aminotranferase (AST), alanine aminotranferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were measured with autoanalyzer. Plasma concentration of Hcy, serum cTn I, and levels of NO were determined with ELISA method and value of activity erythrocyte glutathione peroxidase (GSH-Px) was measured with spectrophotometer. Before treatment, values of plasma Hcy, serum NO, cTn I, AST, ALT, ALP, CK, and LDH in lambs with NMD were higher than those of healthy ones (P<0.001), while GSH-Px activity of lambs with NMD are lower than those of healthy (P<0.001). After ten days of treatment, there were no significant diff erences between treated lambs with NMD and healthy lambs. Nutritional myodegeneration in lambs is associated with increased levels of Hcy, cTn I, and NO. Increased levels of Hcy, cTn I, and NO may be a result of selenium deficiency causing myocardial disorder in NMD lambs. Keywords: Nutritional Myodegeneration, Lamb, Homocysteine, Troponin I, Nitric oxide Subklinik Beyaz Kas Hastalıklı Kuzularda Homosistein, Troponin I ve Nitrik Oksit Düzeylerinin Değerlendirilmesi ÖzetBeyaz kas hastalığı veya besinsel kas dejenerasyonları, hayvanlarda iskelet ve kalp kaslarının dejeneratif değişiklikleri ile karakterize bir hastalığıdır. Bu çalışmada kuzulardaki subklinikal beyaz kas hastalığında plazma homosistein (Hcy), serum kardiak troponin I (cTnI) ve nitrik oksit (NO) düzeyleri araştırıldı. Çalışmada 10 sağlıklı ve 20 subklinikal beyaz kas hastalıklı kuzu kullanıldı. Kan örnekleri NMD kuzularda tedavi öncesi, tedavi sonrası 3. ve 10. günlerde ve kontrol grubunda bir kez alındı. Serum kreatinin kinaz (CK), aspartat aminotransferaz (AST), alanin aminotranferaz (ALT), alkalin fosfataz (ALP) ve laktat dehidrogenaz (LDH) değerleri otoanalizatör cihazıyla ölçüldü. Plazma homosistein konsantrasyonu, serum cTn I ve NO düzeyleri ELİSA cihazıyla ve eritrosit glutathione peroxidase (GSH-Px) aktivitesi ise spektrofotometre cihazıyla ölçüldü. Tedavi öncesi, kuzuların subklinik beyaz kas hastalığında GSH-Px aktiviteleri sağlıklı kuzulara göre daha düşük iken (P<0.001), plazma Hcy, serum NO, cTn I, AST, ALT, ALP, CK ve LDH değerleri sağlıklı kuzuların değerlerinden yüksek bulundu (P<0.001). Tedavi sonrası 10. günde elde edilen ortalama değerler, kontrol grubunun değerlerinden farklı değildi. Kuzuların subklinik beyaz kas hastalığında Hcy, cTn I ve NO değerlerindeki yükselmelerin, selenyum eksikliğinin sebep olduğu miyokardiyal ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Subklinik Beyaz Kas Hastalıklı Kuzularda Homosistein, Troponin I ve Nitrik Oksit Düzeylerinin Değerlendirilmesi

Kozat¹,

Altuğ²,

Yüksek³

et al. 2009

Kafkas Univ Vet Fak Derg

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“…AST, ALT, CK enzyme levels indicative of skeletal muscle damage are elevated (1,4,7,17). The ALT level in healthy sheep is around 22-84 (U/L) (3,20).…”

Section: Tab 2 Biochemical Parametersmentioning

confidence: 99%

“…The level of AST, an indicator of the degree of skeletal muscle damage, is reported as 30-280 (U/L) in healthy sheep (1,2,7,13,17,20). Differences in AST levels between the control group and group A in this study were statistically insignificant.…”

Section: Tab 2 Biochemical Parametersmentioning

confidence: 99%

Examination of sheep in which injection of Yeldif® induced sudden death

Uyar

Yener

Başbuğan

et al. 2017

Medycyna Weterynaryjna

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Two breeders from the Başkale district of the Van province and the Hizan district of the Bitlis province reported deaths of their lambs one day after injection of a commercial preparation containing a combination of Se and Vit E (Yeldif®). Purulent-hemorrhagic-necrotic myositis was detected at the injection site during necropsy of the lambs (2 animals) brought to the Pathology Department of our Faculty by these breeders. This study was conducted to determine whether these post-injection deaths occurred as a result of the drug used or due to a faulty application of the medicine by the breeders. The trial period for this study was 1 week. Eighteen 2-month-old lambs were used in this study. The lambs were divided into three groups (control and 2 study groups) of 6 lambs each. An injection of 1 ml (recommended dose) of the product purchased in the market from the same batch as the one that had caused the deaths was administered I.M. to lambs in the control group. The medicine reported to have caused the deaths by the breeders was administered to the first study group (A) at 1 ml I.M. and to the second study group (B) at 3 ml I.M. (three times the recommended dose). The lambs were bled for biochemical analysis before the administration, on the first day after the administration, and at the end of the trial. Necropsies were performed on dead animals during the trial and on all animals at the end of the trial. At the end of the trial, no clinical-pathological findings were noted in lambs of the control group and group A. However, in all lambs of group B, emphysematous gangrene was detected at the injection site. Cl. chauvoei was isolated and identified in bacteriological and cultural examinations. It was concluded that bacterial contamination occurred as a result of incorrect drug administration by the breeders and injection of a high dose of the contaminated drug.

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Micronutrient Imbalance

and¹,

Jones²

2007

Diseases of Sheep

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Muscle enzymes in the diagnosis of ovine weaner nutritional myopathy

Cited by 16 publications

References 13 publications

Subklinik Beyaz Kas Hastalıklı Kuzularda Homosistein, Troponin I ve Nitrik Oksit Düzeylerinin Değerlendirilmesi

Subklinik Beyaz Kas Hastalıklı Kuzularda Homosistein, Troponin I ve Nitrik Oksit Düzeylerinin Değerlendirilmesi

Examination of sheep in which injection of Yeldif® induced sudden death

Micronutrient Imbalance

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