Muscle-derived stem cells: important players in peripheral nerve repair

Musavi, Leila; Brandacher, Gerald; Höke, Ahmet; Darrach, Halley; Lee, W P Andrew; Kumar, Anand; Lopez, Joseph

doi:10.1080/14728222.2018.1539706

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…In some publications, MDSCs have been suggested to have neurogenic capacity and therapeutic effects on PNI . Moreover, previous studies have verified that MDSCs can secrete growth factors to achieve the promotion of regeneration . We suspected that the combination of the epimysium and MDSCs could create a synergistic beneficial effect, as their origins are the same as those of skeletal muscle, which was confirmed by our results.…”

Section: Discussionsupporting

confidence: 86%

Grafted muscle‐derived stem cells promote the therapeutic efficiency of epimysium conduits in mice with peripheral nerve gap injury

Chen

Feng

et al. 2019

Artificial Organs

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Our research aimed to build allogeneic artificial conduits with epimysium and muscle-derived stem cells (MDSCs) from the skeletal muscle of mice. We applied the conduit to repair peripheral nerve defects and estimated the effectiveness of the repair process. In the research, we prepared epimysium conduits with lumens to bridge repair a 5-mm-long sciatic nerve defect from C57 wild-type mice and then transplanted green fluorescent protein (GFP)-MDSCs and Matrigel suspensions into the conduit. Histological and functional assessments were performed 4 and 8 weeks after surgery. The tissue-engineered conduit from muscle effectively repaired the nerve defect, while the group with GFP-MDSCs showed improved histological examinations and functional assessments, and the newborn nerves highly expressed GFP. As the results suggested, autologous epimysium conduits represent a reliable method to repair peripheral nerve defects, and the addition of MDSCs promote the effectiveness of differentiating into multiple lineages. Our research simultaneously demonstrated the myogenic, neurogenic, and angiogenic potential of MDSCs in vivo for the first time. K E Y W O R D S microsurgery, peripheral nerve injury, regenerative medicine, stem cells, tissue engineering | E215 XU et al.

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Section: Discussionsupporting

confidence: 86%

Grafted muscle‐derived stem cells promote the therapeutic efficiency of epimysium conduits in mice with peripheral nerve gap injury

Chen

Feng

et al. 2019

Artificial Organs

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“…Bone-marrow-derived stem cells are the most studied stem cells, adipose-derived stem cells (ASCs) and have a wide range of differentiation capabilities, including blood cells, myoblasts, bone cells, adipocytes, and neurons. [161] Figure 11. A) Schematic of the hybrid material NGC manufacturing process and in vivo performance.…”

Section: Stem Cellmentioning

confidence: 99%

“…Bone‐marrow‐derived stem cells are the most studied stem cells, adipose‐derived stem cells (ASCs) and have a wide range of differentiation capabilities, including blood cells, myoblasts, bone cells, adipocytes, and neurons. [ 161 ] The acquisition of BMSCs is a particularly painful process, whereas ASCs are easier to obtain and can be isolated in large numbers during liposuction, and ASCs are often induced to differentiate into Schwann cell‐like cells, which enhance neuronal survival, stimulate neurite growth, improve myelin formation, and promote nerve regeneration. Under appropriate culture conditions, ASCs are capable of forming cell sheets composed of cells, intercellular linker molecules, and abundant ECM, which can be rolled into rods to form engineered neural tissue and promote peripheral nerve repair.…”

Section: New Generation Functional Nerve Conduit With Large Gap Nerve...mentioning

confidence: 99%

Advances in Large Gap Peripheral Nerve Injury Repair and Regeneration with Bridging Nerve Guidance Conduits

Shen

et al. 2023

Macromolecular Bioscience

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Peripheral nerve injury is a common complication of accidents and diseases. The traditional autologous nerve graft approach remains the gold standard for the treatment of nerve injuries. While sources of autologous nerve grafts are very limited and difficult to obtain. Nerve guidance conduits are widely used in the treatment of peripheral nerve injuries as an alternative to nerve autografts and allografts. However, the development of nerve conduits does not meet the needs of large gap peripheral nerve injury. Functional nerve conduits can provide a good microenvironment for axon elongation and myelin regeneration. Herein, the manufacturing methods and different design types of functional bridging nerve conduits for nerve conduits combined with electrical or magnetic stimulation and loaded with Schwann cells, etc., are summarized. It summarizes the literature and finds that the technical solutions of functional nerve conduits with electrical stimulation, magnetic stimulation and nerve conduits combined with Schwann cells can be used as effective strategies for bridging large gap nerve injury and provide an effective way for the study of large gap nerve injury repair. In addition, functional nerve conduits provide a new way to construct delivery systems for drugs and growth factors in vivo.

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“…A recent study showed that SCA-1, CD34, and CD45 may be reasonable markers for the identification of MDSCs [21]. It is generally established that MDSCs express the mesenchymal stem cell markers CD73, CD90, and CD105 [22], and some other positive markers have been revealed, including CD29, CD44, and CD133 [23][24][25][26].…”

Section: Mdscsmentioning

confidence: 99%

The role and therapeutic potential of stem cells in skeletal muscle in sarcopenia

et al. 2022

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Sarcopenia is a common age-related skeletal muscle disorder featuring the loss of muscle mass and function. In regard to tissue repair in the human body, scientists always consider the use of stem cells. In skeletal muscle, satellite cells (SCs) are adult stem cells that maintain tissue homeostasis and repair damaged regions after injury to preserve skeletal muscle integrity. Muscle-derived stem cells (MDSCs) and SCs are the two most commonly studied stem cell populations from skeletal muscle. To date, considerable progress has been achieved in understanding the complex associations between stem cells in muscle and the occurrence and treatment of sarcopenia. In this review, we first give brief introductions to sarcopenia, SCs and MDSCs. Then, we attempt to untangle the differences and connections between these two types of stem cells and further elaborate on the interactions between sarcopenia and stem cells. Finally, our perspectives on the possible application of stem cells for the treatment of sarcopenia in future are presented. Several studies emerging in recent years have shown that changes in the number and function of stem cells can trigger sarcopenia, which in turn leads to adverse influences on stem cells because of the altered internal environment in muscle. A better understanding of the role of stem cells in muscle, especially SCs and MDSCs, in sarcopenia will facilitate the realization of novel therapy approaches based on stem cells to combat sarcopenia.

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Muscle-derived stem cells: important players in peripheral nerve repair

Cited by 6 publications

References 59 publications

Grafted muscle‐derived stem cells promote the therapeutic efficiency of epimysium conduits in mice with peripheral nerve gap injury

Grafted muscle‐derived stem cells promote the therapeutic efficiency of epimysium conduits in mice with peripheral nerve gap injury

Advances in Large Gap Peripheral Nerve Injury Repair and Regeneration with Bridging Nerve Guidance Conduits

The role and therapeutic potential of stem cells in skeletal muscle in sarcopenia

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