Muscle Biopsy Studies in Liver Cirrhosis

Maschio, Giuseppe; D’Angelo, Armando; Sirigu, F; Ossi, Elena; Polin, Richard A.; Fagiolo, U; Naccarato, R.

doi:10.3109/00365527109181134

Cited by 19 publications

(8 citation statements)

References 3 publications

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“…The mean control muscle potassium concentration of 424 ± 28 mEq/kg FFDS is similar to data previously reported in the literature (table III) [2,8,16,17,24,29,37]. In the dialyzed patients the muscle potassium concentration was significantly less with a mean of 350 ±81 mEq/kg FFDS (p ^0.001).…”

Section: Resultssupporting

confidence: 79%

See 1 more Smart Citation

Tissue Potassium in Chronic Dialysis Patients

Butkus¹,

Alfrey²,

Miller³

1974

Nephron

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Postmortem tissue analysis revealed significant potassium deficits in 58% of 27 patients maintained on chronic hemodialysis for periods of 2–75 months against dialysates containing 0–2.6 mEq/l of potassium. Potassium depletion was observed with all dialysate potassium concentrations but was greatest in patients dialyzed against potassium-free baths. The potassium deficit occurred primarily in skeletal muscle, myocardium, and brain. Myocardial potassium concentration was severely reduced in the majority of patients maintained on potassium-free dialysates and also correlated closely with muscle potassium concentration.

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Section: Resultssupporting

confidence: 79%

“…The mean myocardial potassium concentration in the controls was 353 ± 31 mEq/kg FFDS, which is slightly less than the mean of 380 mEq/kg FFDS derived from the data of [29] 448 ± 29 G raham ct at. [16] 426 ± 36 G raham and Scobie [17] 397 ± 291 431 ±41'-D ubois et at.…”

Section: Resultsmentioning

confidence: 97%

Tissue Potassium in Chronic Dialysis Patients

Butkus¹,

Alfrey²,

Miller³

1974

Nephron

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“…Thus changes in serum potassium concentration have very little effect on overall TBK values. Furthermore, intracellular potassium content in patients with cirrhosis has been measured in muscle (15), RBCs (16) and leukocytes (17,18). In none of these studies was there evidence of intracellular potassium depletion.…”

Section: Discussionmentioning

confidence: 99%

Distribution of body water in patients with cirrhosis: The effect of liver transplantation

et al. 1993

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We compared total body water and intracellular-extracellular distribution of body water between male patients with mild liver disease without ascites (n = 9), male patients with severe liver disease and gross ascites (n = 6) and a group of age-, sex-, height- and weight- matched controls (n = 6). In addition, we documented the effects of liver transplantation on intracellular, extracellular and total body water in 12 patients (6 men and 6 women) by means of deuterium oxide dilution and whole-body potassium counting. We saw no significant difference in total body water between the healthy controls, patients without ascites and patients with ascites (46.5 +/- 9.2 kg, 45.4 +/- 6.6 kg and 50.4 +/- 5.1 kg, respectively), although, as expected, extracellular water was increased in patients with ascites compared with healthy controls and cirrhotic patients without ascites (36.9 +/- 6.5 kg vs. 25.4 +/- 4.4 kg, p = 0.005; and 36.9 +/- 6.5 kg vs. 27.0 +/- 5.3 kg, p = 0.002, respectively). We found no difference between non-ascitic patients and healthy controls (25.4 +/- 4.4 kg vs. 27.0 +/- 5.3 kg). However, intracellular water was significantly reduced in patients with severe liver disease compared with that in controls (13.6 +/- 3.3 kg vs. 21.5 +/- 4.2 kg, p = 0.005) or patients without ascites (13.6 +/- 3.3 kg vs. 18.3 +/- 2.9 kg, p = 0.01). The reduction of intracellular water appears to be due to loss of body cell mass.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Consequently (in the setting of only a slight increase in TBW) this indicates that BCM may be significantly decreased in patients without ascites. This assumes that the proportion of intracellular mass constituted by water is the same or increased in patients with cirrhosis; this observation has been described previously (24, 26, [40][41][42][43].…”

Section: Discussionmentioning

confidence: 91%

Measurements of total body and extracellular water in cirrhotic patients with and without ascites

McCullough

1991

Hepatology

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Using H2[18O] tracer isotope dilution and corrected bromide space as standard reference techniques, we determined total body water and extracellular water in cirrhotic patients with (four men and four women) and without (seven men and six women) ascites and compared them with a normal control group (eight men and six women). These results were then compared with calculations of total body and extracellular water determined by the bioelectrical impedance analysis technique. According to H2[18(O)] dilution, total body water was similar in cirrhotic patients without ascites and in controls (60.8% +/- 2.1% vs. 60.3% +/- 1.4% body wt), but was increased in patients with ascites (69.7% +/- 1.2% body wt; p less than 0.002). Correlation was excellent between the H2[18(O)] dilution and bioelectrical impedance measurements of total body water in controls and cirrhotic patients without ascites (r = 0.98; p less than 0.0001). However, this correlation was poor in cirrhotic patients with ascites (r = 0.17; not significant). According to the bromide space, extracellular water (expressed as a percentage of total body water) was increased in cirrhotic patients with (57.8% +/- 1.8%; p less than 0.001) and without (44.0% +/- 1.2%; p less than 0.001) ascites compared with controls (36.6% +/- 1.0%). A poor correlation (r = 0.41; p less than 0.13) was seen for extracellular water measurements between the bromide space method and the bioelectrical impedance method, which failed to detect the differences among the three groups observed with the bromide space technique. Furthermore, bioelectrical impedance failed to detect any change in total body or extracellular water after paracentesis, with a degree of inaccuracy that increased linearly as the amount of ascitic fluid removed increased (r = 0.97; p less than 0.001). All these intergroup comparisons remained the same, whether the analysis was of both men and women combined or for each gender individually. However, we saw differences between men and women in the control group and cirrhotic group without ascites. These results demonstrate that abnormalities in water homeostasis and compartmentalization between intracellular (the difference between total body and extracellular water fluid) and extracellular water may exist in cirrhosis whether or not fluid accumulation is clinically evident. These data further indicate that alterations in the metabolically active body cell mass (as represented by intracellular water) in cirrhosis may occur independently of total body water and calculated fat-free body mass. In addition, gender is an important variable to control for in studies of this type.(ABSTRACT TRUNCATED AT 400 WORDS)

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Muscle Biopsy Studies in Liver Cirrhosis

Cited by 19 publications

References 3 publications

Tissue Potassium in Chronic Dialysis Patients

Tissue Potassium in Chronic Dialysis Patients

Distribution of body water in patients with cirrhosis: The effect of liver transplantation

Measurements of total body and extracellular water in cirrhotic patients with and without ascites

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