Musanahol: a new aureonitol-related metabolite from a Chaetomium sp.

Marwah, Ruchi G.; Fatope, Majekodunmi O.; Deadman, M. L.; Al-Maqbali, Y. M.; Husband, John

doi:10.1016/j.tet.2007.05.119

Cited by 59 publications

(38 citation statements)

References 24 publications

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“…(−)‐Musanahol and 3‐ epi ‐aureonitol isolated from a Chaetomium sp. were found with antibacterial activity . In this article, compounds 2 and 3 are two new oxidation products of aureonitol and compound 2 exhibited the antitumor activity.…”

Section: Introductionsupporting

confidence: 53%

Novel Metabolites from the Endophytic Fungus Chaetomium subaffine L01

Han

Xie

et al. 2019

Chemistry & Biodiversity

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One natural p-terphenyl glycoside, gliocladinin C, and two furano-polyene derivatives, chaetominins A and B, were isolated from potato endophytic fungus Chaetomium subaffine. The absolute configurations of these compounds were elucidated by HR-ESI-MS, NMR, the DP4 + probabilities and electronic circular dichroism (ECD) spectra. Furthermore, gliocladinin C and chaetominin A showed cytotoxic activity against two selected human tumor cell lines (Hep-2 and HepG-2).

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Section: Introductionsupporting

confidence: 53%

Novel Metabolites from the Endophytic Fungus Chaetomium subaffine L01

Han

Xie

et al. 2019

Chemistry & Biodiversity

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“…Ten of them were used as the representative target to study the molecular mechanism of 27 ligands of Chaetomium fungal endophyte from diverse plants [21][22][23][24][25][26][27]. On the other hand, the proteins being used as the target are methylerythritol phosphate cytidyltransferase (PDB 1I52) [28], maltose binding periplasmic protein (MBP; PDB 1JVY) [29], glutamine-fructose-6-phosphate aminotransferase (PDB 1MOS) [30], -aminobutyrate aminotransferase (PDB 1SZS) [31], DNA gyrase (PDB 4DUH) [32] , enoylreductase (PDB 1I30) [33] , isoleucyl t-RNA synthetase (PDB 1JZQ) [34], aspartate aminotransferase (PDB 1IX6) [35], acetylglutamate kinase (PDB 1OHA) [36], and peptidyl t-RNA hydroxylase (PDB 2PTH) [37].…”

Section: In Silico Activity Against Protein Targets In E Colimentioning

confidence: 99%

Antimicrobial, antioxidant, and cytotoxic activities of endhopitic fungi Chaetomium sp. isolated from Phyllanthus niruri Linn: in vitro and in silico studies

Rollando

Notario

Monica

et al. 2017

J. Pure App. Chem. Res.

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Endophytic fungi Chaetomium sp isolated from Phyllanthus niruri Linn. Mycelium powder was extracted by using ethyl acetate. Extract was fractionated using n-hexane, dichloromethane and ethanol 96%. The antimicrobial test was carried out using disc diffusion and microdilution methods. The antioxidant activity of the fraction was determined using hydrogen peroxide free radical scavenging and reducing power capacity activities. The cytotoxicity assay of the fraction against T47D breast cancer cell was carried out using dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide method (MTT). The in silico prediction of chemical substances which are reported exist in Chaetomium sp. performed using AutoDockVina embedded in PyRx version 8.0. Dichloromethane fraction was found as the most active sample against Escherichia coli (IC 50 20.76 g/mL), Staphylococcus aureus (IC 50 70.15 g/mL), Salmonella typhi (49.13 g/mL) and was found as the most high phenolic content with value 47.44 mg GAE/g fraction, whereas the best antioxidant activity was performed by ethanol 96% fraction (85%). Cytotoxicity assay against T47D cell line showed dichloromethane fraction have highest activity with IC 50 10.76 g/mL. The docking studies showed that compounds bearing xanthone structure were potential for maltose binding periplasmic and human aromatase associating with their potencies as antibacteria and anticancer. Endophytic fungi Chaetomium sp. was isolated from Phyllanthus niruri using n-hexane, dichloromethane and ethanol fractions was studied its various biological activities as antimicrobial, antioxidant and cytotoxic agent against breast cancer cell.

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“…In searching new active ligands, a number of 27 compounds (see Table 1) from Chaetomium sp., was utilized as the database to be virtually screened using 1G50 as the protein target (Marwah et al, 2007;Abdel-Lateff, 2008;Qin et al, 2009;Li et al, 2011;Wang et al, 2012;Wang et al, 2015;Li et al, 2015;). As results, Table 2 presented the Gbind, the amino acids which contribute to its binding via Hbonding along with its H-bond distances.…”

Section: Wp2mentioning

confidence: 99%