Murine lymphocytic choriomeningitis: the history of a natural cross-infection from wild to laboratory mice

Skinner, H. H.; Knight, E. H.; Grove, Rosemary

doi:10.1258/002367777780936422

Cited by 18 publications

(13 citation statements)

References 6 publications

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“…For example, 90% of male Norway rats >500 g in Baltimore, Maryland, had antibody to Seoul virus (15), and 88% of male cotton rats >200 g in southern Florida had antibody reactive with SNV (12). These prevalences are comparable to the highest prevalences for agents reported to be vertically transmitted such as some arenaviruses including Lassa (22) and lymphocytic choriomeningitis viruses (23).…”

Section: Comparison Of Snv Prevalence With Prevalence Of Other Rodentsupporting

confidence: 53%

Long-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: A Synthesis

Mills¹,

Ksiazek²,

Peters³

et al. 1999

Emerg. Infect. Dis.

216

217

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A series of intensive, longitudinal, mark-recapture studies of hantavirus infection dynamics in reservoir populations in the southwestern United States indicates consistent patterns as well as important differences among sites and host-virus associations. All studies found a higher prevalence of infection in older (particularly male) mice; one study associated wounds with seropositivity. These findings are consistent with horizontal transmission and transmission through fighting between adult male rodents. Despite very low rodent densities at some sites, low-level hantavirus infection continued, perhaps because of persistent infection in a few long-lived rodents or periodic reintroduction of virus from neighboring populations. Prevalence of hantavirus antibody showed seasonal and multiyear patterns that suggested a delayed density-dependent relationship between prevalence and population density. Clear differences in population dynamics and patterns of infection among sites, sampling periods, and host species underscore the importance of replication and continuity of long-term reservoir studies. Nevertheless, the measurable associations between environmental variables, reservoir population density, rates of virus transmission, and prevalence of infection in host populations may improve our capacity to model processes influencing infection and predict increased risk for hantavirus transmission to humans.

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Section: Comparison Of Snv Prevalence With Prevalence Of Other Rodentsupporting

confidence: 53%

Long-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: A Synthesis

Mills¹,

Ksiazek²,

Peters³

et al. 1999

Emerg. Infect. Dis.

216

217

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“…transplantable tumour or serum), the source of contamination often is unknown. Wild rodents may contribute to laboratory outbreaks and have been implicated in prior outbreaks of infectious agents in laboratory colonies (Skinner et al 1977, Barthold 1998. In many urban areas, wild rats live in close proximity to universities and research centres, may frequent laboratory animal receiving areas and may even enter laboratory housing areas (e.g.…”

Section: Resultsmentioning

confidence: 99%

A survey of rodent-borne pathogens carried by wild-caught Norway rats: A potential threat to laboratory rodent colonies

et al. 2008

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SummaryUnintentional infection of laboratory rodents can compromise scientific research as well as the health of the animals and animal handlers. The source of contamination often is unknown, but may be introduced by wild rats from surrounding environments. To determine whether rats in Baltimore, Maryland, USA carry infectious agents commonly found in laboratory rodent colonies, we live-trapped 162 rats during 2005 to 2006 and screened them for a panel of viruses, bacteria and parasites. Antibodies against rat coronavirus/ sialodacryoadenitis virus (91.7%), Mycoplasma pulmonis (72.9%), cilia-associated respiratory bacillus (52.1%), rat parvovirus/rat minute virus (29.2%), Kilham rat virus (10.4%), Toolan's H-1 virus (10.4%), Sendai virus (4.2%) and Theiler's mouse encephalomyelitis virus (4.2%), were detected in wild-caught Norway rats. Antibodies against reovirus and pneumonia virus of mice were not detected in wild Norway rats. Endoparasites, including Nippostrongylus braziliensis (71.6%), Rodentolepis nana or Hymenolepis diminuta (34.4%), Hetarakis spumosa (24.1%) and Trichuris muris (14.8%), as well as ectoparasites (14.8%), were identified in wild-caught rats. The risk of pathogen transmission from wild-caught rats to laboratory colonies needs to be mitigated by minimizing exposures rather than assuming wild animals represent a minimal hazard.

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“…In urban Baltimore, however, single-dwelling units in the same neighborhood showed antibody prevalence to LCMV from 0% to 50% ( 8 ). In an LCMV epizootic of laboratory mice in the United Kingdom, bite transmission occurred and antibody prevalence was 67% in wild mice that were caught ( 11 ). Over a few generations, every member of a colony may become infected, as vertical transmission approaches 100% efficiency ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Lymphocytic Choriomeningitis in Michigan

Foster

Signs

Marks

et al. 2006

Emerg. Infect. Dis.

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Murine lymphocytic choriomeningitis: the history of a natural cross-infection from wild to laboratory mice

Cited by 18 publications

References 6 publications

Long-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: A Synthesis

Long-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: A Synthesis

A survey of rodent-borne pathogens carried by wild-caught Norway rats: A potential threat to laboratory rodent colonies

Lymphocytic Choriomeningitis in Michigan

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