Lymphocytic Choriomeningitis in Michigan

Abstract

We summarize the first reported case of acquired lymphocytic choriomeningitis virus (LCMV) infection in Michigan to be investigated by public health authorities and provide evidence of the focal nature of LCMV infection in domestic rodents. Results of serologic and virologic testing in rodents contrasted, and negative serologic test results should be confirmed by tissue testing.

Congenital lymphocytic choriomeningitis virus infection: spectrum of disease

“…Human children and adults acquire LCMV infections either by contact with fomites contaminated with infectious virus recently shed by rodents, by inhaling aerosolized virus, or via transplanted organs or tissues 2, 7, 9, 10. LCMV infection during postnatal life typically consists of a brief febrile illness from which the patient fully recovers 11. Classic signs and symptoms are those of aseptic meningitis and include fever, headache, myalgia, anorexia, vomiting, and photophobia.…”

Lymphocytic choriomeningitis virus infection of the developing brain: critical role of host age

“…The prototypical arenavirus, LCMV is the causative agent of a zoonosis typically acquired from chronically viremic wild mice 1, 2. In children and adults, LCMV infection commonly induces asymptomatic seroconversion or aseptic meningitis, from which the patient fully recovers 3, 4. A more serious problem arises when the infection occurs during pregnancy.…”

Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation — Minnesota, 2015

“…The fecal pellets tested positive for LCMV (1) by PCR, implicating the mouse infestation as the likely source of the patient's infection. A 2006 case report from Michigan identified household rodents as the source of a human LCMV infection, which was confirmed through necropsy, serology, and tissue testing of trapped mice; fecal pellet testing in that case was negative for LCMV (2). This is the first report to identify LCMV-infected mice through fecal pellet testing.…”