Mupirocin calcium microencapsulation via spray drying: feed solvent influence on microparticle properties, stability and antimicrobial activity

Dürrigl, Marjana; Kregar, Maja Lusina; Hafner, Anita; Klarić, Maja Šegvić; Filipović-Grčić, Jelena

doi:10.3109/03639045.2011.580350

Cited by 15 publications

(3 citation statements)

References 37 publications

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“…Encapsulation efficiency was close to theoretical value in case of methacrylate-based microparticles and slightly lower for chitosan-based microparticles ( Table 1). The values obtained are within the range of previously reported data for similar systems (Dürrigl et al, 2011b;Filipovi c-Gr9 ci c et al, 2003;Rizi et al, 2011).…”

Section: Preparation Of Microparticlessupporting

confidence: 80%

Development and validation of an in vitro release method for topical particulate delivery systems

Kregar

Dürrigl

Rožman

et al. 2015

International Journal of Pharmaceutics

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Section: Preparation Of Microparticlessupporting

confidence: 80%

Development and validation of an in vitro release method for topical particulate delivery systems

Kregar

Dürrigl

Rožman

et al. 2015

International Journal of Pharmaceutics

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“…8,43 Mupirocin works against a broad spectrum of bacteria by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis. 48 The DLS showed excellent activity against all tested microorganisms, with the strongest activity against S. aureus (35 mm), followed by P. aeruginosa (30 mm) and then by E. coli (28 mm). Overall, the DLS exhibited significant activity against S. aureus, E. coli, and P. aeruginosa.…”

Section: Antibacterial Activitymentioning

confidence: 93%

Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications

Li¹,

Wang²,

Yang³

et al. 2018

IJN

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BackgroundAn ideal wound dressing should exhibit good biocompatibility, minimize pain and infection, absorb excess exudates, and maintain a moist environment. However, few clinical products meet all these needs. Therefore, the aim of this study was to fabricate a multifunctional double layer nanofibrous scaffolds (DLS) as a potential material for wound dressing.Materials and methodsThe scaffold was formed from mupirocin and lidocaine hydrochloride homogeneously incorporated into polycaprolactone as the first layer of scaffolds and chitosan as the second layer of scaffolds nanofibers through electrospinning. The fabricated nanofibrous scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and measurement of swelling ratio, contact angle, drug release, and mechanical properties. Furthermore, antibacterial assessment, live/dead cell assays, and MTT assays were used to investigate the antibacterial activity and cytotoxicity of the nanofibrous scaffolds.ResultsThe morphology of the nanofibrous scaffolds was studied by scanning electron microscopy, showing successful nanofibrous scaffolds. Fourier transform infrared spectroscopy demonstrated the successful incorporation of the material used to produce the produced nanofibrous scaffolds. Thermal studies with thermogravimetric analysis and differential scanning calorimetry indicated that the DLS had high thermal stability. The DLS also showed good in vitro characteristics in terms of improved swelling ratio and contact angle. The mechanical results revealed that the DLS had an improved tensile strength of 3.88 MPa compared with the second layer of scaffold (2.81 MPa). The release of drugs from the scaffold showed different profiles for the two drugs. Lidocaine hydrochlo ride exhibited an initial burst release (66% release within an hour); however, mupirocin exhibited only a 5% release. Furthermore, the DLS nanofibers displayed highly effective antibacterial activities against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa and were nontoxic to fibroblasts.ConclusionThe fabricated DLS exhibited excellent hydrophilicity, cytocompatibility, sustained drug release, and antibacterial activity, which are favorable qualities for its use as a multifunctional material for wound dressing applications.

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“…It is also important to note that any prospective usage of such microsystems in skin therapy requires adjustment of the initial dose of a once-a-day formulation. Moreover, a negligible impact was observed on the drug-loaded microparticle performance after 10 months of storage [52].…”

Section: Microcapsulementioning

confidence: 92%

Recent Advances in Mupirocin Delivery Strategies for the Treatment of Bacterial Skin and Soft Tissue Infection

Gangwar

Kumar²,

Singh

et al. 2021

Future Pharmacology

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Skin and soft tissue infections (SSTIs) have increased problematically in hospital and ambulatory settings due to the poor immunity of hosts and multidrug-resistant pathogens. Mupirocin (MUP), a global topical antibiotic, is used for the treatment of SSTIs caused by various pathogens due to its unique mechanism of action. However, the therapeutic efficiency of MUP is hampered due to the protein binding and drug resistance caused by frequent use. A combined report covering the various aspects of MUP, such as the synthesis of the novel formulation, loading of the drug, and application against various skin infections, is missing. This comprehensive review focuses on various novel drug delivery strategies such as composite biomaterials/scaffold, hydrogel dressings, liposomes, liposomal hydrogel, microparticles/microspheres, microsponges, nanocapsules, nanofibers, silicone-based adhesive patches, and topical sprays. The therapeutic effect of the MUP can be synergized by combining with other agents and using novel strategies. The objective is to enhance patient compliance, decrease the resistance, magnify the delivery of MUP, and overcome the limitations of conventional formulations. Moreover, the carriers/dressing materials are biocompatible, biodegradable, stimulate wound healing, protect the wound from external environmental contamination, adsorb the wound exudates, and are permeable to oxygen and moisture. This review will help researchers to explore further the treatment of various bacterial skin infections by using MUP-loaded novel formulations with better efficacy, utilizing the novel nanostructures or combinatorial methods.

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Mupirocin calcium microencapsulation via spray drying: feed solvent influence on microparticle properties, stability and antimicrobial activity

Abstract: Acrylic-based MP were confirmed as suitable microcarriers for prolonged drug release using a well-established spray drying technique, while solvent influence was strongly related to the DL employed.

Cited by 15 publications

References 37 publications

Development and validation of an in vitro release method for topical particulate delivery systems

Development and validation of an in vitro release method for topical particulate delivery systems

Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications

Recent Advances in Mupirocin Delivery Strategies for the Treatment of Bacterial Skin and Soft Tissue Infection

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