Munich Consensus Development Conference on Histamine Determination

Lorenz, W.; Neugebauer, E.; Uvnäs, Börje; Beaven, Michael A.; Ennis, Madeleine; Granérus, Göran; Green, J. P.; Keyzer, Jules J.; McBride, Paul; Mannaioni, P. F.; Pearce, F. L.; Watkins, J.

doi:10.1007/978-3-642-75840-9_10

Cited by 7 publications

(4 citation statements)

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“…This finding was in contrast to previous investigations with hydroxyethyl starch (Plasmasteril", Fresenius, Bad Homburg) [10], in which rapid infusion of hydroxyethyl starch caused no histamine release. This difference is due to the fact that the fluorometric histamine assay was improved over a long time with lower detection limits and a higher sensitivity [20,21]. Anaphylactoid histamine release reactions pose serious safety hazards to patients undergoing anaesthesia and surgery because there is a delay between the administration of the treatment and the onset of the reaction an association between the two is unlikely to be made.…”

Section: Discussionmentioning

confidence: 99%

Early and late histamine release induced by albumin, hetastarch and polygeline: some unexpected findings

Çelik

Duda

Stinner³

et al. 2003

Inflammation Research

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Section: Discussionmentioning

confidence: 99%

Early and late histamine release induced by albumin, hetastarch and polygeline: some unexpected findings

Çelik

Duda

Stinner³

et al. 2003

Inflammation Research

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“…This assay compares favourably with other techniques, according to a quality control study [18]. It was shown to have equal sensitivity and accuracy as the fluorimetric assay, and to be convenient to use for plasma samples at the Munich Consensus Development Conference on Histamine Determination [19]. According to the manufacturer, the sensitivity is 0.2 nmol litre" 1 .…”

Section: Discussionmentioning

confidence: 99%

Radioimmunoassay for plasma histamine: a study of false positive and false negative values

Laroche

Dubois

Gérard

et al. 1995

British Journal of Anaesthesia

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In order to achieve a correct diagnosis of drug anaphylaxis using a radioimmunoassay devoid of interferences, we have studied factors leading to false positive or false negative values of plasma histamine. Different steps in sample collection were studied systematically in 30 normal volunteers. False positive values were found in haemolysed samples, with histamine concentrations being correlated with haemoglobin concentrations, and where plasma was aspirated from the white-cell layer. There was no significant increase when a tourniquet or vacuum tubes were used, or when blood tubes were left at 4 degrees C overnight. In 12 patients who experienced an anaphylactic reaction, histamine disappeared from blood 10 times more slowly than expected. False negative values were found in two pregnant women and one heparinized patient. Histamine was remarkably stable in vitro in blood or plasma samples, whereas it disappeared rapidly when plasma from a pregnant woman or a heparinized patient was added to the sample. We conclude that false positive and false negative values are rare when using this radioimmunoassay.

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“…It is important to emphasize that all the four trials used the same rigid criteria for the fluorometricfluoroenzymatic plasma histamine assay as described by LORENZ et al [58] and modified by LORENZ and NEUGEBAUER [73] and demanded in the Consensus Conference on Histamine Assays [74]. Plasma catecholamines were determined by a HPLC-technique [21].…”

Section: Methods Applied In All Four Trialsmentioning

confidence: 99%

Perioperative nonspecific histamine release : a new classification by aetiological mechanisms and evaluation of their clinical relevance

Duda¹,

Lorenz

Menke

et al. 1993

Annales Françaises d'Anesthésie et de Réanimation

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RI~SUM#: Les auteurs ont r6alis6 quatre 6tudes prospectives dans le but d'6tudier les diff6rents facteurs responsables de la lib6ration d'histamine dans la p6riode p6dop6ratoire. Les r6actions allergiques vraies et les r6actions pseudo-allergiques ne sont pas seules en cause. De nombreux autres m6canismes d'histaminolib6ration sont sugg6r6s : m6canismes neuroendocriniens, lib6ration cons6cutive ,~ des stimuli nociceptifs, facteurs cytotoxiques cons6cutifs au traumatisme tissulaire de l'acte chirurgical et lib6ration induite par les cytokines. Ces mdcanismes ont 6t6 mis en 6vidence darts deux 6tudes prospectives 6tudiant, l'une des patients lors d'une gastroscopie r6alis6e sans pr6m6dication et l'autre, des patients b6n6ficiant d'une chol6cystectomie perccelioscopique. Darts une autre 6tude, une histaminolib6ration par mdcanisme pseudoallergique a 6t6 not6e imm6diatement apr~s l'induction anesth6sique chez un hombre important de patients op6r6s pour divers acres de chirurgie g6n6rale. Dans ces deux cas, I'histaminolib6ration est ind6sirable car elle est ~a l'origine de sympt6mes de gravit6 variable. Les signes cliniques sont surtout cardiovasculaires et respiratoires alors que les signes cutan6s sont souvent absents. Les auteurs consid~-rent que dans la pdriode p6riop6ratoire la lib6ration d'histamine est ind6sirable dans certains cas mais darts d'autres elle n'a pas de cons6quences n6fastes, pouvant m6me 6tre b6n6fique. Une r66valuation des signes cliniques d'histaminolib6ration est n6cessaire puisque les 6tudes ont montr6 que des concentrations plasmatiques de 12 ng. ml -~ d'histamine souvent ne s'accompagnaient d'aucun signe cutan6. Ainsi une histaminolib6ration non sp6cifique n'est, le plus souvent, pas reconnue comme cause d'une hypotension art6rielle p6riop6ratoire en raison du manque de sp6cificit6 de ce sympt6me. Des 6tudes ult6rieures doivent pr6ciser le r61e des m6dicaments antihistaminiques (anti-H1 et anti-H2, doses, choix des patients, moment de Fadministration) darts la pr6vention de l'histaminolib6ration p6riop6ratoire. CLASSIFICATION OF PERIOPERATIVE HISTAMINE RELEASEIn the last conference on prevention of perianaesthetic anaphylactoid reactions, Nancy, 1984 [52], a whole series of mechanisms for nonspecific histamine release was not mentioned at all [62]. Surgical trauma was included, but only one reference could be given at this time [93] and did not challenge the general opinion over 50 years that ,~ histamine does not play an important role in major injury or traumatic shock, [1, 311In this conference [54], however, a considerable increase of knowledge has to b~ reported which creates new hypotheses on functions of histamine in clinical epidemiology ( fig. 1). A new classification has to be found which does not only alter aetiology, but also pathogenesis and disease manifestations, especially in the perioperative and postoperativ e period.

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Munich Consensus Development Conference on Histamine Determination

Cited by 7 publications

References 20 publications

Early and late histamine release induced by albumin, hetastarch and polygeline: some unexpected findings

Early and late histamine release induced by albumin, hetastarch and polygeline: some unexpected findings

Radioimmunoassay for plasma histamine: a study of false positive and false negative values

Perioperative nonspecific histamine release : a new classification by aetiological mechanisms and evaluation of their clinical relevance

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