Mumps outbreak in a highly vaccinated student population, The Netherlands, 2004

Brockhoff, Heinrich J.; Mollema, Liesbeth; Sonder, Gerard J.B.; Postema, C. A.; Binnendijk, Robert S. van; Kohl, Robert H.G.; Melker, Hester E. de; Hahné, Susan

doi:10.1016/j.vaccine.2010.02.020

Cited by 62 publications

(51 citation statements)

References 13 publications

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“…2,3 Although it was assumed that mumps vaccination induces life-long protection, 4 several mumps outbreaks, especially among vaccinated student populations, have been reported during the last decade in various countries where mumps vaccination has been implemented into their national immunization programs. [5][6][7][8][9][10][11][12][13][14] In 2009-2012, a mumps epidemic (genotype G) arose that spread across multiple locations within the Netherlands, in which also primarily vaccinated students were affected. 15 Waning of vaccine-induced immunity has been suggested to play a role in these outbreaks.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of the serologic response in vaccinated and unvaccinated mumps cases during an epidemic

Kaaijk

Gouma

Hulscher

et al. 2015

Human Vaccines & Immunotherapeutics

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Abbreviations: MMR, measles mumps and rubella; ND 50 , reciprocal virus-neutralizing antibody dose; VN, virus-neutralizing antibody; RU/ml, RIVM units per ml; GMC, geometric mean concentration; 95% CI, lower and upper 95% confidence intervals of GMCIn the last decade, several mumps outbreaks were reported in various countries despite high vaccination coverage. In most cases, young adults were affected who have acquired immunity against mumps solely by vaccination and not by previous wild-type mumps virus infection. To investigate mumps-specific antibody levels, functionality and dynamics during a mumps epidemic, blood samples were obtained longitudinally from 23 clinical mumps cases, with or without a prior history of vaccination, and from 20 healthy persons with no serological evidence of recent mumps virus infection. Blood samples from mumps cases were taken 1-2 months and 7-10 months after onset of disease. Both vaccinated and unvaccinated mumps cases had significantly higher geomean concentrations of mumps-specific IgG (resp. 13,617 RU/ml (95% CI of 9,574-19,367 RU/ml) vs. 1,552 (445-5412) RU/ml at 1-2 months; and 6,514 (5,247-8,088) RU/ml vs. 1,143 (480-2,725) RU/ml at 7-10 months) than healthy controls (169 (135-210) RU/ml) (p D 0.001). Patterns in virus-neutralizing (VN) antibody responses against the mumps vaccine virus were similar, vaccinated and unvaccinated mumps cases had significantly higher ND 50 values at both time points of sampling (resp 4,695 (3,779-5,832) RU/ml vs. 1,533 (832-2,825) RU/ml at 1-2 months; 2,478 (1,968-3,122) RU/ml vs. 1,221 (1,029-1,449) RU/ml at 7-10 months) compared with (previously vaccinated) healthy controls (122 (196-76)) RU/ml) (p D 0.001) The unvaccinated mumps cases had significantly lower mumps-specific IgG and VN antibody concentrations at both sampling points compared with previously vaccinated cases, but their antibody concentrations did not differ significantly at the 2 time points. In contrast, the mumps-specific IgG and VN antibody concentrations of the previously vaccinated mumps cases were significantly higher within the first 2 months after onset of mumps and declined thereafter, characteristic for a secondary response. A moderate correlation was found between the level of mumps-specific IgG serum antibodies and VN antibodies for the mumps cases (r D 0.64; p<0.001).

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Section: Introductionmentioning

confidence: 99%

Dynamics of the serologic response in vaccinated and unvaccinated mumps cases during an epidemic

Kaaijk

Gouma

Hulscher

et al. 2015

Human Vaccines & Immunotherapeutics

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“…Mumps outbreaks among two-dose vaccine recipients are not unique to the United States or to the Jeryl Lynn vaccine strain (the only licensed mumps vaccine in the United States). In fact, mumps outbreaks among vaccinated populations have occurred in numerous countries, some of which utilize different strains of vaccine virus (5)(6)(7)(8)(9)(10)(11)(12).…”

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confidence: 99%

Estimates of Mumps Seroprevalence May Be Influenced by Antibody Specificity and Serologic Method

Latner

McGrew

Williams

et al. 2013

Clin. Vaccine Immunol.

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Neutralizing antibodies are assumed to be essential for protection against mumps virus infection, but their measurement is labor-and time-intensive. For this reason, enzyme-linked immunosorbent assays (ELISAs) are typically used to measure mumpsspecific IgG levels. However, since there is poor correlation between mumps neutralization titers and ELISAs that measure the presence of mumps-specific IgG levels, ELISAs that better correlate with neutralization are needed. To address this issue, we measured mumps antibody levels by plaque reduction neutralization, by a commercial ELISA (whole-virus antigen), and by ELISAs specific for the mumps nucleoprotein and hemagglutinin. The results indicate that differences in the antibody response to the individual mumps proteins could partially explain the lack of correlation among various serologic tests. Furthermore, the data indicate that some seropositive individuals have low levels of neutralizing antibody. If neutralizing antibody is important for protection, this suggests that previous estimates of immunity based on whole-virus ELISAs may be overstated.

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“…[4][5][6] A concern that always arises in such outbreaks is the documentation of mumps vaccine doses. The documentation of 2 doses of MMR vaccine in this outbreak is reliable as it was obtained from the state immunization registry or from the healthcare provider's office or immunization records.…”

Section: Discussionmentioning

confidence: 99%

“…However, mumps outbreaks among high two-dose vaccinated populations have been recently reported in literature, both within the United States and internationally. [3][4][5][6][7][8] In New York State, school immunization laws for measles, mumps, and rubella have been implemented since 1968. 9 In 1989, Public Health Law (PHL) (Section 2165) was enacted to require students attending post-secondary institutions who were born on or after January 1, 1957, to have 2 doses of measles, 1 dose of mumps and 1 dose of rubella vaccine.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and the economic assessment of a mumps outbreak in a highly vaccinated population, Orange County, New York, 2009–2010

Kutty

Lawler

Rausch‐Phung

et al. 2014

Human Vaccines & Immunotherapeutics

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Mumps outbreak in a highly vaccinated student population, The Netherlands, 2004

Cited by 62 publications

References 13 publications

Dynamics of the serologic response in vaccinated and unvaccinated mumps cases during an epidemic

Dynamics of the serologic response in vaccinated and unvaccinated mumps cases during an epidemic

Estimates of Mumps Seroprevalence May Be Influenced by Antibody Specificity and Serologic Method

Epidemiology and the economic assessment of a mumps outbreak in a highly vaccinated population, Orange County, New York, 2009–2010

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