Epidemiology and the economic assessment of a mumps outbreak in a highly vaccinated population, Orange County, New York, 2009–2010

Kutty, Preeta K.; Lawler, Jacqueline; Rausch‐Phung, Elizabeth; Ortega-Sánchez, Ismael R.; Goodell, Stephen; Schulte, Cynthia; Pollock, Lynn; Valure, Barbara; Hudson, Jean M.; Gallagher, Kathleen; Blog, Debra

doi:10.4161/hv.28389

Cited by 20 publications

(9 citation statements)

References 34 publications

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“…Most cases were appropriately vaccinated; 89% of the mumps cases aged 13-17 y had received 2 previous vaccine doses. 7,13 The main complications reported in the current study were 3.8% mumps orchitis in males >12 y old and 0.5% meningoencephalitis (higher in under-vaccinated cases), comparable to In 2010, mumps notifications from Israel accounted for about one fifth of all the European Region cases. 15 The mumps virus genotype G (identified in the described outbreak) has been prevalent in the WHO European Region during 2005-2011.…”

Section: Discussionmentioning

confidence: 85%

Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases

Stein‐Zamir

Schroeder

Shoob

et al. 2015

Human Vaccines & Immunotherapeutics

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In recent years, large mumps outbreaks, involving mainly adolescents and young adults, have re-emerged in several countries. We investigated a large mumps outbreak, evaluated the association between mumps clinical severity (complications, hospitalization) and vaccination status (number of previous measles, mumps and rubella -MMR vaccine doses), and assessed vaccine effectiveness. The first mumps cases emerged in an ultra-orthodox boys' school in Jerusalem and were epidemiologically linked to the mumps outbreak in New York. Overall, 3130 mumps cases were notified in the Jerusalem district during September 2009-August 2011 (median age 13y, 64% males). Most cases were reported from community clinics. Patients with systemic symptoms and/or complications (419, 13.4%) were either hospitalized (n D 79) or treated in an emergency medical center (n D 340). The main complications included orchitis (3.8% males> age 12y) and meningoencephalitis (0.5%). The mumps virus genotype was G5. The distribution of previous MMR vaccine doses (n D 0,1,2) was: 24.8%, 28.3% and 46.9%, respectively. The number of previous vaccine doses was inversely associated with clinical severity. Adjusted values for MMR vaccine effectiveness against complications were estimated as 52.1% (95% CI ¡4 ¡78%) for one vaccine dose and 62.7% (95% CI 25.7-81.3%) for 2 doses. The outbreak was characterized by predominance of male students; the majority of whom had been previously vaccinated. The reported complication rate was relatively low. Vaccination status was associated with age and disease severity. The combination of limited mumps vaccine effectiveness and the specific school setting (dense learning and living conditions) probably contributed to the disease spread.

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Section: Discussionmentioning

confidence: 85%

Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases

Stein‐Zamir

Schroeder

Shoob

et al. 2015

Human Vaccines & Immunotherapeutics

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“…However, few studies have assessed the economic burden of mumps outbreaks. Only 2 other studies have reported cost data from the public health perspective; in these outbreaks, a third-dose MMR intervention was used [18, 19]. Cost estimates are difficult to compare across outbreaks because of differences in methods used to calculate containment cost and in outbreak setting types.…”

Section: Discussionmentioning

confidence: 99%

“…The overall cost for outbreak response and control was estimated at $256 785; the economic impact per household with ≥1 mumps case was estimated at $761, with days missed from work because of illness or caregiving for a child with mumps accounting for most of the cost. The second study was conducted during a mumps outbreak in a highly vaccinated population in Orange County, New York, in 2009–2010; 790 mumps cases were reported [18]. The highest attack rate was in adolescents aged 11–17 years.…”

Section: Discussionmentioning

confidence: 99%

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Cost of Public Health Response and Outbreak Control With a Third Dose of Measles-Mumps-Rubella Vaccine During a University Mumps Outbreak—Iowa, 2015–2016

Marin

Kitzmann

James

et al. 2018

Open Forum Infectious Diseases

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BackgroundThe United States is experiencing mumps outbreaks in settings with high 2-dose measles-mumps-rubella (MMR) vaccine coverage, mainly universities. The economic impact of mumps outbreaks on public health systems is largely unknown. During a 2015–2016 mumps outbreak at the University of Iowa, we estimated the cost of public health response that included a third dose of MMR vaccine.MethodsData on activities performed, personnel hours spent, MMR vaccine doses administered, miles traveled, hourly earnings, and unitary costs were collected using a customized data tool. These data were then used to calculate associated costs.ResultsApproximately 6300 hours of personnel time were required from state and local public health institutions and the university, including for vaccination and laboratory work. Among activities demanding time were case/contact investigation (36%), response planning/coordination (20%), and specimen testing and report preparation (13% each). A total of 4736 MMR doses were administered and 1920 miles traveled. The total cost was >$649 000, roughly equally distributed between standard outbreak control activities and third-dose MMR vaccination (55% and 45%, respectively).ConclusionsPublic health response to the mumps outbreak at the University of Iowa required important amounts of personnel time and other resources. Associated costs were sizable enough to affect other public health activities.

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“…Earlier reports have associated vaccination against MMR with the occurrence of ASD in children ( 62 ), thus leading in particularly low vaccination coverage. As a result, outbreaks regarding the vaccine preventable strains have reappeared throughout Europe ( 63 – 65 ), Asia ( 66 , 67 ) and the United States ( 68 , 69 ). Extensive research around the issue has emerged, soundly dissociating MMR vaccination from any ASD occurrence, even in high-risk populations ( 70 – 72 ).…”

Section: Update On Current Views and Advances On Paediatric Virologymentioning

confidence: 99%

Current views and advances on Paediatric Virology: An update for paediatric trainees

Mammas

Greenough

Theodoridou

et al. 2015

Experimental and Therapeutic Medicine

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Paediatric Virology is a bold new scientific field, which combines Paediatrics with Virology, Epidemiology, Molecular Medicine, Evidence-based Medicine, Clinical Governance, Quality Improvement, Pharmacology and Immunology. The Workshop on Paediatric Virology, which took place on Saturday October 10, 2015 in Athens, Greece, provided an overview of recent views and advances on viral infections occurring in neonates and children. It was included in the official programme of the 20th World Congress on Advances in Oncology and the 18th International Symposium on Molecular Medicine, which attracted over 500 delegates from the five continents. During the Workshop, the topics covered included the challenges of vaccine implementation against human papillomaviruses in countries under financial crisis, strategies for eradicating poliomyelitis and its 60th vaccine anniversary, as well as the debate on the association between autism and vaccination against measles, mumps and rubella. Among the non-vaccine related topics, emphasis was given to viral infections in prematurely born infants and their long-term outcomes, new paediatric intensive care management options for bronchiolitis related to respiratory syncytial virus, the clinical implications of hepatitis B virus and cytomegalovirus genotyping, the Ebola virus threat and preparedness in Paediatric Emergency Departments, oral, oropharynx, laryngeal, nasal and ocular viral infections and Merkel cell polyomavirus as a novel emerging virus of infancy and childhood. In this review, we provide selected presentations and reports discussed at the Workshop.

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Epidemiology and the economic assessment of a mumps outbreak in a highly vaccinated population, Orange County, New York, 2009–2010

Cited by 20 publications

References 34 publications

Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases

Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases

Cost of Public Health Response and Outbreak Control With a Third Dose of Measles-Mumps-Rubella Vaccine During a University Mumps Outbreak—Iowa, 2015–2016

Current views and advances on Paediatric Virology: An update for paediatric trainees

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