Multiwalled Carbon Nanotubes Inhibit Tumor Progression in a Mouse Model

García‐Hevia, Lorena; Villegas, Juan; Fernández, Freddy Delgado; Casafont, Íñigo; González, J.; Valiente, Rafael; Fanarraga, Mónica L.

doi:10.1002/adhm.201500753

Cited by 33 publications

(28 citation statements)

References 39 publications

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“…In this study, HeLa cells exposed to nanotubes display an elongated morphology (Figure 1(c)), abnormal mitotic figures (Figure 1(d)), and aberrant cell cycles (Figure 1(e)) where we can see an increased S and/or G2 phases, depending on the incubation dose/times. Confocal microscopy examination of MWCNT-treated cell cultures confirmed indicative signs of the biomechanical and disruptive effects of these nanotubes on HeLa cells, including (i) cell retraction, (ii) membrane blebbing, (iii) nuclear DNA compaction, and (iv) the presence of micronuclei, as well as other previously described cytoskeletal changes including disorganized microtubular patterns or a reactive cortical actin [14]. These morphological changes and cytotoxic effects were corroborated by flow cytometry (Figure 1 3 Journal of Nanomaterials 3.2.…”

Section: Resultssupporting

confidence: 67%

“…For example, macrophages generally suffer more cumulative or degradative effects-i.e., reactive oxygen species (ROS) accumulation-than other cells for the same material at the same dose due to their high avidity for capturing nanomaterials [8][9][10][11][12][13]. On the contrary, malignant melanoma or glioblastoma multiforme cells have great resistance to cytotoxicity for most nanomaterials [7,14,15]. Also, some cells have a special idiosyncrasy that makes them tolerant to certain types of nanomaterials, such as neurons.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Size, Shape, and Composition on the Interaction of Different Nanomaterials with HeLa Cells

Renero-Lecuna

Iturrioz-Rodríguez

González-Lavado

et al. 2019

Journal of Nanomaterials

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The application of nanomaterials in the fields of medicine and biotechnology is of enormous interest, particularly in the areas where traditional solutions have failed. Unfortunately, there is very little information on how to optimize the preparation of nanomaterials for their use in cell culture and on the effects that these can trigger on standard cellular systems. These data are pivotal in nanobiotechnology for the development of different applications and to evaluate/compare the cytotoxicity among the different nanomaterials or studies. The lack of information drives many laboratories to waste resources performing redundant comparative tests that often lead to partial answers due to differences in (i) the nature of the start-up material, (ii) the preparation, (iii) functionalization, (iv) resuspension, (v) the stability/dose of the nanomaterial, etc. These variations in addition to the different analytical systems contribute to the artefactual interpretation of the effects of nanomaterials and to inconsistent conclusions between different laboratories. Here, we present a brief review of a wide range of nanomaterials (nanotubes, various nanoparticles, graphene oxide, and liposomes) with HeLa cells as a reference cellular system. These human cells, widely used as cellular models for many studies, represent a reference system for comparative studies between different nanomaterials or conditions and, in the last term, between different laboratories.

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Section: Resultssupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Effect of Size, Shape, and Composition on the Interaction of Different Nanomaterials with HeLa Cells

Renero-Lecuna

Iturrioz-Rodríguez

González-Lavado

et al. 2019

Journal of Nanomaterials

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“…They tested the cytotoxicity of bare MWCNTs, and they found that they can easily enter inside the cells and intermingle with the protein nanofilaments of the cytoskeleton, interfering with the mitosis (cell division) biomechanics. Such a behavior mimics the effect of some commonly-used anti-cancer drugs, like paclitaxel [147]. …”

Section: Cnts and Cancermentioning

confidence: 92%

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

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Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation. Nevertheless, deep investigations about carbon nanotubes’ potential bio-compatibility and cytotoxicity limits should be also critically addressed. In the present review, after introducing carbon nanotubes and their promising advantages and drawbacks for fighting cancer, we want to focus on the numerous and different ways in which they can assist to reach this goal. Specifically, we report on how they can be used not only for drug delivery purposes, but also as a powerful ally to develop effective contrast agents for tumors’ medical or photodynamic imaging, to perform direct physical ablation of metastasis, as well as gene therapy.

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“…[318–322] Additionally, it has been reported that MWCNTs themselves can also inhibit tumor growth. [323] Wang et al combined Au together with single-walled carbon nanotubes (SWNTs). [324] With modification with folic acid (FA), this CNT could be uptaken in KB cells, as visualized by Raman imaging after exposure with NIR light, and also offered enhanced photothermal cancer cell kill.…”

Section: Theranostic Nanomaterialsmentioning

confidence: 99%

Advanced Functional Nanomaterials for Theranostics

Huang

Lovell

2016

Adv Funct Materials

196

121

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Nanoscale materials have been explored extensively as agents for therapeutic and diagnostic (i.e. theranostic) applications. Research efforts have shifted from exploring new materials in vitro to designing materials that function in more relevant animal disease models, thereby increasing potential for clinical translation. Current interests include non-invasive imaging of diseases, biomarkers and targeted delivery of therapeutic drugs. Here, we discuss some general design considerations of advanced theranostic materials and challenges of their use, from both diagnostic and therapeutic perspectives. Common classes of nanoscale biomaterials, including magnetic nanoparticles, quantum dots, upconversion nanoparticles, mesoporous silica nanoparticles, carbon-based nanoparticles and organic dye-based nanoparticles, have demonstrated potential for both diagnosis and therapy. Variations such as size control and surface modifications can modulate biocompatibility and interactions with target tissues. The needs for improved disease detection and enhanced chemotherapeutic treatments, together with realistic considerations for clinically translatable nanomaterials will be key driving factors for theranostic agent research in the near future.

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Multiwalled Carbon Nanotubes Inhibit Tumor Progression in a Mouse Model

Cited by 33 publications

References 39 publications

Effect of Size, Shape, and Composition on the Interaction of Different Nanomaterials with HeLa Cells

Effect of Size, Shape, and Composition on the Interaction of Different Nanomaterials with HeLa Cells

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

Advanced Functional Nanomaterials for Theranostics

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