2019
DOI: 10.3390/pr7110806
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Multivariate Analysis of Plasma Metabolites in Children with Autism Spectrum Disorder and Gastrointestinal Symptoms Before and After Microbiota Transfer Therapy

Abstract: Current diagnosis of autism spectrum disorder (ASD) is based on assessment of behavioral symptoms, although there is strong evidence that ASD affects multiple organ systems including the gastrointestinal (GI) tract. This study used Fisher discriminant analysis (FDA) to evaluate plasma metabolites from 18 children with ASD and chronic GI problems (ASD + GI cohort) and 20 typically developing (TD) children without GI problems (TD − GI cohort). Using three plasma metabolites that may represent three general group… Show more

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Cited by 13 publications
(14 citation statements)
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References 48 publications
(57 reference statements)
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“…This suggests that some individuals may respond differently to MTT than others. This finding was similar to the analysis performed on plasma metabolites where a steep decline in median discriminant score was also observed at Week 3 and Week 10 [ 29 ].…”
Section: Discussionsupporting
confidence: 87%
See 2 more Smart Citations
“…This suggests that some individuals may respond differently to MTT than others. This finding was similar to the analysis performed on plasma metabolites where a steep decline in median discriminant score was also observed at Week 3 and Week 10 [ 29 ].…”
Section: Discussionsupporting
confidence: 87%
“…None of the metabolites identified as being utilized in the optimum multivariate models were previously identified as being significant for classification in the multivariate plasma models. The general performance of the fecal metabolites when subjected to univariate analysis had generally lower AUROC values than plasma metabolites [ 29 ]. However, despite having lower AUROC scores, multivariate analysis achieved high accuracy in distinguishing ASD and TD children.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…We previously published a paper on a multivariate analysis of the plasma data from children who participated in our MTT study ( 32 ). This study reports comprehensive metabolite measurements from children who participated in our MTT study ( 28 , 29 ), focusing on a univariate analysis of plasma and fecal metabolite data.…”
Section: Introductionmentioning
confidence: 99%
“…In humans, intestinal microbiota transplantation has shown very promising results, both against gastrointestinal tract symptoms and ASD symptoms, granting the therapy a 'fast-track' status by the FDA [29]. Among the plasma metabolites showing average to good classification capacity between the treated children and the controls, sarcosine, tyramine O-sulfate and inosine 5'-monophosphate were selected as most discriminant [30]. Many of these studies postulate that microbiota-derived molecules are transported across the blood-brain-barrier, acting as neuroactive metabolites [23].…”
Section: Introductionmentioning
confidence: 99%