Multivariate Analysis of Fecal Metabolites from Children with Autism Spectrum Disorder and Gastrointestinal Symptoms before and after Microbiota Transfer Therapy

Qureshi, Fatir; Adams, James B.; Hanagan, Kathryn; Kang, Dae Wook; Krajmalnik‐Brown, Rosa; Hahn, Juergen

doi:10.3390/jpm10040152

Cited by 23 publications

(22 citation statements)

References 55 publications

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“…Table 4 illustrates examples from human clinical trials [ 131 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 ]. Not surprisingly, the best outcomes occur when there is a clear understanding of the specific microbes, genes, metabolic changes, and installation conditions that are needed to support microbiome-driven physiological benefits.…”

Section: Probiotics Prebiotics and Targeted Rebiosis: Clinical And Preclinical Examplesmentioning

confidence: 99%

Microbiome First Medicine in Health and Safety

Dietert

2021

Biomedicines

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Microbiome First Medicine is a suggested 21st century healthcare paradigm that prioritizes the entire human, the human superorganism, beginning with the microbiome. To date, much of medicine has protected and treated patients as if they were a single species. This has resulted in unintended damage to the microbiome and an epidemic of chronic disorders [e.g., noncommunicable diseases and conditions (NCDs)]. Along with NCDs came loss of colonization resistance, increased susceptibility to infectious diseases, and increasing multimorbidity and polypharmacy over the life course. To move toward sustainable healthcare, the human microbiome needs to be front and center. This paper presents microbiome-human physiology from the view of systems biology regulation. It also details the ongoing NCD epidemic including the role of existing drugs and other factors that damage the human microbiome. Examples are provided for two entryway NCDs, asthma and obesity, regarding their extensive network of comorbid NCDs. Finally, the challenges of ensuring safety for the microbiome are detailed. Under Microbiome-First Medicine and considering the importance of keystone bacteria and critical windows of development, changes in even a few microbiota-prioritized medical decisions could make a significant difference in health across the life course.

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Section: Probiotics Prebiotics and Targeted Rebiosis: Clinical And Preclinical Examplesmentioning

confidence: 99%

Microbiome First Medicine in Health and Safety

Dietert

2021

Biomedicines

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“…A majority of these changes were sustained and even improved two years after completion of the treatment [65]. Additionally, it was shown that both the plasma and fecal metabolite profiles of the ASD group became more similar to those of their TD counterparts following MTT [66,67]. The effects of FMT have also been evaluated in adult pathogen-free mice using donor and in vitro-cultured human gut microbiota.…”

Section: Fecal Microbiota Transplantation Therapymentioning

confidence: 99%

“…MTT [66,67]. The effects of FMT have also been evaluated in adult pathogen-free mice using donor and in vitro-cultured human gut microbiota.…”

Section: Putative Mechanisms Of the Bgm System Related To Asdmentioning

confidence: 99%

The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder

et al. 2021

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Gastrointestinal dysfunction is one of the most prevalent physiological symptoms of autism spectrum disorder (ASD). A growing body of largely preclinical research suggests that dysbiotic gut microbiota may modulate brain function and social behavior, yet little is known about the mechanisms that underlie these relationships and how they may influence the pathogenesis or severity of ASD. While various genetic and environmental risk factors have been implicated in ASD, this review aims to provide an overview of studies elucidating the mechanisms by which gut microbiota, associated metabolites, and the brain interact to influence behavior and ASD development, in at least a subgroup of individuals with gastrointestinal problems. Specifically, we review the brain-gut-microbiome system and discuss findings from current animal and human studies as they relate to social-behavioral and neurological impairments in ASD, microbiota-targeted therapies (i.e., probiotics, fecal microbiota transplantation) in ASD, and how microbiota may influence the brain at molecular, structural, and functional levels, with a particular interest in social and emotion-related brain networks. A deeper understanding of microbiome-brain-behavior interactions has the potential to inform new therapies aimed at modulating this system and alleviating both behavioral and physiological symptomatology in individuals with ASD.

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“…Numerous maternal body systems have been hypothesized to contribute to ASD including the gastrointestinal, immune, metabolic, and endocrine systems [ 6 , 7 , 8 , 9 , 10 ]. It is not surprising that research has extended these investigations to include the influence of maternal systems disorders.…”

Section: Introductionmentioning

confidence: 99%

Pregnant Mothers’ Medical Claims and Associated Risk of Their Children being Diagnosed with Autism Spectrum Disorder

Grivas

Frye

Hahn

2021

JPM

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A retrospective analysis of administrative claims containing a diverse mixture of ages, ethnicities, and geographical regions across the United States was conducted in order to identify medical events that occur during pregnancy and are associated with autism spectrum disorder (ASD). The dataset used in this study is comprised of 123,824 pregnancies of which 1265 resulted in the child being diagnosed with ASD during the first five years of life. Logistic regression analysis revealed significant relationships between several maternal medical claims, made during her pregnancy and segmented by trimester, and the child’s diagnosis of ASD. Having a biological sibling with ASD, maternal use of antidepressant medication and psychiatry services as well as non-pregnancy related claims such hospital visits, surgical procedures, and radiology exposure were related to an increased risk of ASD regardless of trimester. Urinary tract infections during the first trimester and preterm delivery during the second trimester were also related to an increased risk of ASD. Preventative and obstetrical care were associated with a decreased risk for ASD. A better understanding of the medical factors that increase the risk of having a child with ASD can lead to strategies to decrease risk or identify those children who require increased surveillance for the development of ASD to promote early diagnosis and intervention.

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Multivariate Analysis of Fecal Metabolites from Children with Autism Spectrum Disorder and Gastrointestinal Symptoms before and after Microbiota Transfer Therapy

Cited by 23 publications

References 55 publications

Microbiome First Medicine in Health and Safety

Microbiome First Medicine in Health and Safety

The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder

Pregnant Mothers’ Medical Claims and Associated Risk of Their Children being Diagnosed with Autism Spectrum Disorder

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