Multivariate analysis of factors influencing oral mucositis in allogeneic hematopoietic stem cell transplantation

Ohbayashi, Yumiko; Imataki, Osamu; Ohnìshì, H.; Iwasaki, Atsushi; Ogawa, Takaaki; Inagaki, Noriko; Shigeta, Hiroe; Ohue, Yukiko; Tasaka, Taizo; Kitanaka, Akira; Kubota, Yoshihiro; Tanaka, Terukazu; Ishida, Toshihiko; Miyake, Minoru

doi:10.1007/s00277-008-0508-6

Cited by 31 publications

(21 citation statements)

References 29 publications

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“…The incidence of oral mucositis in the patients with POHC was significantly lower than in those without POHC. The present data support the findings of an earlier retrospective analysis of patients who had received allogeneic HSCT [19]. Whereas the previous study included patients with several graft sources (bone marrow, peripheral blood, and cord blood), we investigated BMT patients alone to observe the effects of POHC more specifically in BMT cases.…”

Section: Discussionsupporting

confidence: 74%

Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation

Kashiwazaki

Matsushita

Sato

et al. 2011

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Section: Discussionsupporting

confidence: 74%

Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation

Kashiwazaki

Matsushita

Sato

et al. 2011

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“…This suggestion is based on two case series [16,20], four non-randomized clinical trials [14,15,19,21], and three RCTs [17, 18; 22 supplemented by 23] (Table 2). The collective evidence was scored as level III.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

Peterson

Öhrn

Bowen

et al. 2012

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115

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Purpose This systematic review analyzed the strength of the literature and defined clinical practice guidelines for the use of oral cryotherapy for the prevention and/or treatment of oral mucositis caused by cancer therapy. Methods A systematic review on relevant oral cryotherapy studies indexed prior to 31 December 2010 was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO) using OVID/MEDLINE, with publications selected for review based on defined inclusion and exclusion criteria. Findings from the reviewed studies were integrated into guidelines based on the overall level of evidence for each intervention. Guidelines were classified into three types: recommendation, suggestion, or no guideline possible. of oral cryotherapy to prevent oral mucositis in patients receiving high-dose melphalan as conditioning regimen with or without total body irradiation for HCST was revised from the 2007 guidelines. No guideline was possible for any other intervention, due to insufficient evidence. Conclusions The evidence continues to support the use of oral cryotherapy for prevention of oral mucositis in patients receiving bolus 5-FU chemotherapy or high-dose melphalan. This intervention is consistent with the MASCC/ISOO guidelines published in 2007. The literature is limited by the fact that utilization of a double-blind study design is not feasible. Future studies that compare efficacy of oral cryotherapy with other mucositis agents in patients receiving chemotherapy with relatively short plasma half-lives would be useful.

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“…Entretanto, ao considerarmos a amostra global, houve um predomínio da leucemia mielóide aguda em 6 (26%) pacientes e da anemia aplástica severa também em 6 (26%) pacientes e do regime de condicionamento Bussulfano e Ciclofosfamida. Dados semelhantes ao da amostra deste estudo foi encontrado por Ohbayashi et al (2008).…”

Section: Discussionunclassified

“…Estudos têm evidenciado que a incidência de mucosite bucal em pacientes transplantados de células-tronco hematopoéticas varia entre 70% a 99% (WARDLEY et al, 2000;SONIS et al, 2001;STIFF, 2001;SHEA et al, 2003;VERA-LLONCH et al, 2007; SILVA; BUSSOLOTI-FILHO, 2007;OHBAYASHI et al, 2008;VAGLIANO et al, 2011).…”

Section: Mucosite Bucalunclassified

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Enxaguatório bucal de chamomilla recutita (camomila): preparo e aplicação na mucosite bucal

Braga¹,

Carvalho²

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A Alessandra e Kátia A Alessandra e Kátia A Alessandra e Kátia A Alessandra e Kátia obrigada pela valiosa ajuda no desenvolvimento deste trabalho.As amigas e colegas de trabalho da EERP As amigas e colegas de trabalho da EERP As amigas e colegas de trabalho da EERP As amigas e colegas de trabalho da EERP----USP, Andréa, Ana A náusea foi a única manifestação relatada por dois pacientes durante a realização do bochecho. Dessa forma, os resultados evidenciaram uma possível ação do enxaguatório contendo Chamomilla recutita na redução da incidência da mucosite, na dose de 1%, em pacientes submetidos ao TCTH, bem como uma menor intensidade de mucosite graus II e III nos grupos que receberam as doses de 1 e 2%. Contudo, para confirmar estes achados faz-se necessário ampliar a amostra deste estudo empregando o método aqui desenvolvido. O enxaguatório bucal de Chamomilla recutita nas dosagens de 0,5; 1 e 2% foi bem tolerado pelos pacientes e demonstrou ser seguro, uma vez que nenhum efeito adverso moderado ou severo foi identificado. Oral mucositis (OM) is an inflammatory complication frequently manifested by patients undergoing Hematopoietic Stem Cell Transplantation (HSCT), as a result of aggressive treatment regimen employed. However, prevention and treatment are still controversial in literature. Chamomile has been used for therapeutic purposes for centuries and has been employed in some HSCT services for both prevention and treatment of OM. However, no studies that investigate its action in this clientele have been identified. Thus, this study aimed to compare the incidence, intensity and duration of oral mucositis in adult patients undergoing HSCT according to the doses (0.5; 1 or 2%) of Chamomilla recutita in mouthwash. The study was carried out in four stages. First an integrative literature review was conducted, in order to identify the scientific evidence available regarding the use of Chamomilla recutita to reduce the occurrence and intensity of inflammatory processes. It was evidenced that Chamomilla recutita is likely to have topic anti-inflammatory action, for several inflammatory disorders. Considering the results of this review and those obtained with studies in vitro and in animals, it was deemed appropriate to develop the clinical study. At the second stage, the plant drug was selected, physical-chemical and microbiological analysis were carried out and quantification of apigenin-7-glucoside was determined. Tests identified the excellent quality of capitula from the selected sample. In sequence, at the third phase, the fluid extract was obtained, whose analysis showed the maintenance of quality and content of active principle. Subsequently, the extract was successfully incorporated in three formulations of mouthwash, according to the dosages proposed for the clinical study (0.5; 1 and 2%). At last, a clinical study with 23 patients who underwent allogeneic HSCT was performed, randomized into four groups. Regarding the incidence of mucositis, 5 (83.3%) patients in group B who received the mouthwash with ...

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Multivariate analysis of factors influencing oral mucositis in allogeneic hematopoietic stem cell transplantation

Cited by 31 publications

References 29 publications

Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation

Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

Enxaguatório bucal de chamomilla recutita (camomila): preparo e aplicação na mucosite bucal

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