Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation

Kashiwazaki, Haruhiko; Matsushita, Takae; Sato, Junichi; Shigematsu, Akio; Kasashi, Kumiko; Yamazaki, Yutaka; Kanehira, Takashi; Yamamoto, Satoshi; Kondo, Takeshi; Endo, Tomoyuki; Tanaka, Junji; Hashino, Satoshi; Nishio, Mitsufumi; Imamura, Masahiro; Kitagawa, Yoshimasa; Inoue, Nozomu

doi:10.1007/s00520-011-1116-x

Cited by 86 publications

(63 citation statements)

References 32 publications

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“…31 When oral hygiene is compromised, gingival and mucosal inflammation caused by oral bacteria increases the risk of OM up to bacteremia. [32][33][34] According to our results, the grade of oral hygiene was not statistically different in the 2 groups. This result was expected due to the strict oral hygiene protocols to which oncohematological patients are subjected according to the international guidelines.…”

Section: Discussionmentioning

confidence: 63%

Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia

Bardellini

Amadori

Schumacher

et al. 2016

Journal of Pediatric Hematology/Oncology

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Summary: The aim of this study was to assess the efficacy of a solution composed by verbascoside, polyvinylpyrrolidone, and sodium hyaluronate (Mucosyte) in the treatment of chemotherapyinduced oral mucositi (OM). Patients between 5 and 18 years receiving chemotherapy for acute lymphoblastic leukemia and with OM grade 1 or 2 were randomized in group A (treated with Mucosyte, 3 mouthwashes/d per 8 d) and group B (treated with placebo, ie, an inert water-based solution, 3 mouthwashes/d per 8 d). The OM scoring was performed at day 1 (diagnosis of OM-T0), after 3 days of treatment (T1), and at day 8 (T2). Pain was evaluated through the visual analog scale with the same timing of OM measurement. A total of 56 patients were included (28 patients per group). Group A experienced a statistically significant decline of OM at T2 (P = 0.0038); a statistically significant difference in pain reduction between 2 groups both at T1 and at T2 (P < 0.005) was observed. The use of Mucosyte mouthwashes in children with chemotherapy-induced OM may be recommended as supportive therapy.

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Section: Discussionmentioning

confidence: 63%

Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia

Bardellini

Amadori

Schumacher

et al. 2016

Journal of Pediatric Hematology/Oncology

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“…It has been reported recently that the state of prior oral health can influence decisively in the appearance of mucositis [19] and a professional oral health care may reduce the incidences of OM as evidenced by Kashiwazaki et al [20] .…”

Section: Discussionmentioning

confidence: 97%

Glutamine: Beneficial to prevent oral mucositis in Mexican children with acute lymphoblastic leukemia?

et al. 2013

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Background: Oral mucositis (OM) is a common side effect of antineoplastic-drug administration. It is frequently related to risk of infection and poor intake of foods and fluids. This might adversely affect the patients' nutritional status, cause dose reductions, prolong treatment time and length of hospital stay, and increases costs of treatment. Aim:To investigate if the use of glutamine (Gln) administered by mouthwash during methotrexate(MTX)-chemotherapy in the consolidation-phase reduces oral mucositis in children with acute lymphoblastic leukemia (ALL).Procedure: A double blind randomized study was conducted from January 2009 to December 2010 with two independent samples. Eligible patients were children with ALL between 0-18 years. These patients were randomized into two groups: an experimental-group and a placebo-group, which received Gln or maltodextrin as placebo.Results: OM occurred in 10.7% of the experimental group and 13.6% in the control group, with no significant difference in the severity or incidence of OM. Conclusions:There was no significant difference in the prevention of OM by mouthwash with Gln vs. placebo. Proper oral hygiene and an adequate hyperhydration regimen before and during MTX-chemotherapy, as well as the measurement of serum-methotrexate concentrations are likely to be sufficient to prevent OM.

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“…These patients present additional complex care needs due to both the primary cancer and the medical complexities during survivorship, potentially with high risk of multiple oral/dental problems and therapy-related oral complications. Oral/dental care before, during, and following cancer therapy requires coordination with the medical providers, as oral disease may affect the timing and efficacy of cancer therapy and, conversely, cancer therapy may affect the feasibility and outcomes of dental treatment [2,5,[7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: General Considerations In Cancer Therapy and Impact On Oral mentioning

confidence: 99%

“…Additionally, urgent and emergent dental needs may be managed when the patient is best able to tolerate the treatment, provided at a time of lowest risk to the patient or with appropriate medical support, to facilitate best outcomes which may reduce the need for additional hospitalization and intensive medical care that may impact survival and increase economic burden of treatment [9,18,19,28,60,61]. Therefore, oral and dental care before, during, and following cancer therapy are an important part of cancer treatment [7] and are best provided by educated and experienced dental providers, with good communication with the oncology team [47].…”

Section: Cancer Survivorsmentioning

confidence: 99%

Appropriate and necessary oral care for people with cancer: guidance to obtain the right oral and dental care at the right time

Epstein

Güneri

Barasch

2014

Support Care Cancer

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Purpose The identification of experienced and knowledgeable dental specialists to provide appropriate oral care for cancer patients, as well as the integration of this care within general oncology management, may be a challenge. This paper discusses the general and additional requirements for dental care providers to support the cancer patient and provide prevention and/or treatment for oral complications of cancer therapy. Methods We performed a literature review of specific issues regarding the oral cavity and adjacent structures in the cancer patient, including detection and early diagnosis of oral malignancy. We incorporated the systemic effects of cancer and its therapy that affect oral disease and treatment. We present a summary of how to seek expert dental care for cancer patients and for referral from the dental and medical community. Results Due to the complexity conferred by the disease and its treatment, cancer patients require educated, experienced dentists for treatment and/or prevention of oral-related morbidity. Correct diagnosis and evidence-based prophylactic and therapeutic oral care can significantly improve patient quality of life and reduce morbidity and healthcare costs. Conclusions The knowledge and expertise of dental professionals regarding prevention/treatment of complications and secondary malignant lesions in cancer patients are critical. Integration of oral care with the oncology care and in survivors requires effective communication between dental and medical providers beginning ideally at diagnosis. These clinicians may be identified at the cancer center, nearby hospital dental programs, and, less commonly, in the community.

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Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation

Abstract: We concluded that POHC reduced the incidences of oral mucositis and FN by upgrading the overall oral hygiene during HSCT.

Cited by 86 publications

References 32 publications

Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia

Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia

Glutamine: Beneficial to prevent oral mucositis in Mexican children with acute lymphoblastic leukemia?

Appropriate and necessary oral care for people with cancer: guidance to obtain the right oral and dental care at the right time

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