Multivalent, bifunctional dendrimers prepared by click chemistry

Wu, Peng; Malkoch, Michael; Hunt, Jasmine N.; Vestberg, Robert; Kaltgrad, Eiton; Finn, M. G.; Fokin, Valery V.; Sharpless, K. Barry; Hawker, Craig J.

doi:10.1039/b512021g

Cited by 444 publications

(317 citation statements)

References 29 publications

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“…As a result, the synthetic methodology to obtain these structures can be seen as complicated, giving rise to tedious purification procedures. The group of Hawker et al 37 reported in 2005 a robust and simplified synthetic protocol for the construction of unsymmetrical dendrimers by taking advantage of the efficiency and orthogonality of the CuAAC reaction. In this strategy, two types of dendrons were grown using anhydride chemistry; one dendron comprised acetylene in the core and the other an azide.…”

Section: Unsymmetrical Dendrimersmentioning

confidence: 99%

New methodologies in the construction of dendritic materials

et al. 2009

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Section: Unsymmetrical Dendrimersmentioning

confidence: 99%

New methodologies in the construction of dendritic materials

et al. 2009

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“…Click chemistry has been widely used as a novel green chemistry in recent years [32][33][34][35][36][37][38][39][40]. click chemistry provides an extensively approach to quickly synthesized new polymer brushes in highly yields without special purification and serious reaction condition.…”

Section: Introductionmentioning

confidence: 99%

A New Approach for the Preparation of Functional Poly(acrylonitrile-g-glycidyl methacrylate) Polymer Brush

Wang¹,

Wang²,

Chen³

et al. 2017

Preprint

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Abstract:A new approach for the preparation of polymer brush was developed via the union of controlled/"living" radical polymerization and click chemistry. The application of the approach realized the more quickly and accurate design and synthesis of the polymer brushes. A novel functional polymer brush of poly(acrylonitrile-g-glycidyl methacrylate) with tremendous application potential in the field of biology has been successfully synthesized via the new approach. The reaction conditions of click chemistry were optimized with the reaction time and the reactant ratio and judged from UV-vis spectra. Under the optimum of click chemistry, the novel functional polymer brushes were prepared. The GPC, FTIR analyses, 1 H NMR spectrum and TGA were employed to ensure the successful synthesis of poly(acrylonitrile-g-glycidyl methacrylate) polymer brushes.

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“…[31,32] The target compounds were synthesized by using click chemistry. [33,34] The three azide dendrons were reacted with the bis-MPA dendron in the presence of Na-ascorbate and Cu(II)SO4 in H2O/THF/DMSO solvent mixture.…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembly of Amphiphilic Janus Dendrimers into Mechanically Robust Supramolecular Hydrogels for Sustained Drug Release

Nummelin

Liljeström

Saarikoski

et al. 2015

Chemistry A European J

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Abstract:Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Here we show that amphiphilic Janus dendrimers with low molecular weights can readily form selfassembled fibers at very low mass proportion (0.2 per cent by mass) creating supramolecular hydrogels (G'>>G'') with outstanding mechanical properties, where the storage modulus G'>1000 Pa. The G' and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure, thus enabling an exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic transmission electron microcopy, small-angle x-ray scattering and scanning electron microscopy were used to confirm the fibrous structure morphology of the gels. Furthermore, we show that the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides or small molecule drugs to be used for sustained release in drug delivery.

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Multivalent, bifunctional dendrimers prepared by click chemistry

Abstract: Unsymmetrical dendrimers, containing both mannose binding units and coumarin fluorescent units, have been prepared using click chemistry and shown to be highly efficient, dual-purpose recognition/detection agents for the inhibition of hemagglutination.

Cited by 444 publications

References 29 publications

New methodologies in the construction of dendritic materials

New methodologies in the construction of dendritic materials

A New Approach for the Preparation of Functional Poly(acrylonitrile-g-glycidyl methacrylate) Polymer Brush

Self‐Assembly of Amphiphilic Janus Dendrimers into Mechanically Robust Supramolecular Hydrogels for Sustained Drug Release

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