Multitasking hyaluronic acid

Seton-Rogers, Sarah

doi:10.1038/nrc3254

Cited by 20 publications

(17 citation statements)

References 1 publication

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“…There are many excellent reviews on the topic [3, 15–18, 249]. An example of the role of HA in cancer can be seen in a recent report on naked mole rats.…”

Section: Hyaluronan In Human Diseasesmentioning

confidence: 99%

“…There are many excellent reviews on the roles of HA in different fields, such as in angiogenesis [4], reactive oxygen species [13], HA digestion [14], cancer [3, 15, 16], cancer therapeutics [17], cancer metastasis [18], chondrocytes [19], lung injury [20–22], wound healing [23], diabetes [24], leukocyte trafficking [25], and in immune regulation [5, 26, 27]. The current review will summarize the role of HA in biological and pathological conditions, and will emphasize the role of HA in human diseases.…”

Section: Introductionmentioning

confidence: 99%

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Hyaluronan as a therapeutic target in human diseases

Liang

Jiang

Noble

2016

Advanced Drug Delivery Reviews

167

106

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Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix and plays an important role in regulating tissue injury and repair, and controlling disease outcomes. The function of hyaluronan depends on its size, location, and interactions with binding partners. While fragmented hyaluronan stimulates the expression of an array of genes by a variety of cell types regulating inflammatory responses and tissue repair, cell surface hyaluronan provides protection against tissue damage from the environment and promotes regeneration and repair. The interactions of hyaluronan and its binding proteins participate in the pathogenesis of many human diseases. Thus, targeting hyaluronan and its interactions with cells and proteins may provide new approaches to developing therapeutics for inflammatory and fibrosing diseases. This review focuses on the role of hyaluronan in biological and pathological processes, and as a potential therapeutic target in human diseases.

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“…There are many excellent reviews on the topic [3, 15–18, 249]. An example of the role of HA in cancer can be seen in a recent report on naked mole rats.…”

Section: Hyaluronan In Human Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyaluronan as a therapeutic target in human diseases

Liang

Jiang

Noble

2016

Advanced Drug Delivery Reviews

167

106

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“…Preliminary experiments confirmed that these requirements are met in the systems described ( Figure 1; see the Supporting Information for details). [12][13][14][15] Consequences include effects on tumor growth, escape from apoptosis,m etastasis formation, and resistance to therapy.P olysaccharides involved in the glycosylation procedure have ah ighly conserved simple composition and are ubiquitously expressed in all animals that have ad eveloped immune response.T he natural production of antibodies that specifically recognize these "weak antigens" is difficult; [16] hence,traditional immunohistochemical methods for detecting glycosylations on cells are rare.A na lternative would be "plastic antibodies" or MIPs. [11] AM IP shell specific for glucuronic acid (GlcA;g reen-QDs) or N-acetylneuraminic acid (NANA; red-QDs) was grafted on top of the hydrophilic first shell ( Figure 1B)t o target glycosylation sites on cells,s ince altered glycosylation levels or distributions are indicators of infection or malignancy.R ecent advances in glycobiology and cancer research have defined the key processes underlying aberrant glycosylation with sialic acids or hyaluronan in cancer and its consequences.…”

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confidence: 99%

Molecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging

et al. 2016

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Advanced tools for cell imaging are of great interest for the detection, localization, and quantification of molecular biomarkers of cancer or infection. We describe a novel photopolymerization method to coat quantum dots (QDs) with polymer shells, in particular, molecularly imprinted polymers (MIPs), by using the visible light emitted from QDs excited by UV light. Fluorescent core-shell particles specifically recognizing glucuronic acid (GlcA) or N-acetylneuraminic acid (NANA) were prepared. Simultaneous multiplexed labeling of human keratinocytes with green QDs conjugated with MIP-GlcA and red QDs conjugated with MIP-NANA was demonstrated by fluorescence imaging. The specificity of binding was verified with a non-imprinted control polymer and by enzymatic cleavage of the terminal GlcA and NANA moieties. The coating strategy is potentially a generic method for the functionalization of QDs to address a much wider range of biocompatibility and biorecognition issues.

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“…In normal ECM, HA exerts beneficial effects on tissue homeostasis and the biomechanical integrity, structure and assembly of tissues . In contrast, in malignant tumor tissues, HA is known to promote aggressiveness of cancer cells …”

Section: Discussionmentioning

confidence: 99%

Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling

et al. 2019

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Hyaluronic acid synthase 2 (HAS2) is suggested to play a critical role in malignancy and is abnormally expressed in many carcinomas. However, its role in colorectal cancer (CRC) malignancy and specific signaling mechanisms remain obscure. Here, we report that HAS2 was markedly increased in both CRC tissue and malignant CRC cell lines. Depletion of HAS2 in HCT116 and DLD1 cells, which express high levels of HAS2, critically increased sensitivity of radiation/oxaliplatin‐mediated apoptotic cell death. Moreover, downregulation of HAS2 suppressed migration, invasion and metastasis in nude mice. Conversely, ectopic overexpression of HAS2 in SW480 cells, which express low levels of HAS2, showed the opposite effect. Notably, HAS2 loss‐ and gain‐of‐function experiments revealed that it regulates CRC malignancy through TGF‐β expression and SMAD2/Snail downstream components. Collectively, our findings suggest that HAS2 contributes to malignant phenotypes of CRC, at least partly, through activation of the TGF‐β signaling pathway, and shed light on the novel mechanisms behind the constitutive activation of HAS2 signaling in CRC, thereby highlighting its potential as a therapeutic target.

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Multitasking hyaluronic acid

Cited by 20 publications

References 1 publication

Hyaluronan as a therapeutic target in human diseases

Hyaluronan as a therapeutic target in human diseases

Molecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging

Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling

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